1. Behavioral variant frontotemporal dementia with pathogenic variant in MAPT presenting as dementia with Lewy body disease.
- Author
-
Xia T, Li C, Iverson A, Spat-Lemus J, Woroch A, and Naasan G
- Subjects
- Humans, Male, Aged, Hallucinations etiology, Hallucinations physiopathology, Hallucinations diagnosis, Frontotemporal Dementia genetics, Frontotemporal Dementia diagnosis, Frontotemporal Dementia pathology, Frontotemporal Dementia physiopathology, tau Proteins genetics, Lewy Body Disease genetics, Lewy Body Disease diagnosis, Lewy Body Disease complications, Lewy Body Disease pathology
- Abstract
A 75-year-old Chinese American man presented to behavioral neurology clinic for a second opinion of dementia with Lewy body disease (DLB). The clinical manifestations met the criteria for a probable DLB diagnosis. Yet, in-depth evaluation unveiled clinical history, family history, and neuroimaging evidences that suggested a diagnosis of behavioral variant frontotemporal dementia (FTD). A heterozygous pathogenic variant in the microtubule-associated protein Tau ( MAPT ) was identified through genetic testing and confirmed the diagnosis of autosomal dominant MAPT -related FTD. This case is the first reported instance of MAPT -related FTD presenting with well-formed visual hallucinations in an elderly Chinese American.
- Published
- 2025
- Full Text
- View/download PDF