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Start Over Author "Dianne A, Cruz" Journal neurobiology of stress
1 results on '"Dianne A, Cruz"'

1. BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls

Author

Keith A. Young, Peter M. Thompson, Dianne A. Cruz, Douglas E. Williamson, and Lynn D. Selemon

Subjects
Post-traumatic stress disorder, Post-mortem, Dendritic spine, FKBP5, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495
Abstract

Genetic variants of the immunophilin FKBP5 have been implicated in susceptibility to post-traumatic stress disorder (PTSD) and other stress-related disorders. We examined the relationship between mushroom, stubby, thin and filopodial spine densities measured with Golgi staining and FKBP5 gene expression in the medial orbitofrontal cortex (BA11) in individuals diagnosed with PTSD and normal controls (n = 8/8). ANCOVA revealed PTSD cases had a significantly elevated density of stubby spines (29%, P

Published
2015
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