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Your search keyword '"Marina Gabriel-Salazar"' showing total 2 results
Start Over Author "Marina Gabriel-Salazar" Journal neurobiology of disease
2 results on '"Marina Gabriel-Salazar"'

1. Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice

Author

Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, and Anna Rosell

Subjects
Cerebral ischemia, MMP-13, Angiogenesis, Neurorepair, Neurogenesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

New neuroreparative and neuroprotective therapies are being sought to treat stroke patients. One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs) are thought to be key players. Our aim was to investigate the role of MMP-13 (collagenase-3) in the acute (24 h and 3 days) and delayed (2 weeks) phases of stroke. Permanent and transient cerebral ischemia models involving the cortex were induced in MMP-13 knock-out (KO) and wild-type (WT) mice. In the transient model, MMP-13 deficiency reduced the amount of TTC-stained infarct tissue, reduced hemorrhagic events and improved functional outcomes (p

Published
2016
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2. Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice

Author

Dolors Giralt, Feifei Ma, Marina Gabriel-Salazar, Verónica Barceló, Anna Rosell, Joan Montaner, Anna Morancho, and Pablo Martinez-San Segundo

Subjects
0301 basic medicine, Doublecortin Protein, Angiogenesis, Neurogenesis, Ischemia, Matrix metalloproteinase, Pharmacology, Neuroprotection, lcsh:RC321-571, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Neurorepair, Matrix Metalloproteinase 13, Medicine, Animals, cardiovascular diseases, Progenitor cell, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Stroke, Mice, Knockout, business.industry, Infarction, Middle Cerebral Artery, Cerebral ischemia, medicine.disease, Disease Models, Animal, 030104 developmental biology, Neurology, Ischemic Attack, Transient, MMP-13, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

New neuroreparative and neuroprotective therapies are being sought to treat stroke patients. One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs) are thought to be key players. Our aim was to investigate the role of MMP-13 (collagenase-3) in the acute (24 h and 3 days) and delayed (2 weeks) phases of stroke. Permanent and transient cerebral ischemia models involving the cortex were induced in MMP-13 knock-out (KO) and wild-type (WT) mice. In the transient model, MMP-13 deficiency reduced the amount of TTC-stained infarct tissue, reduced hemorrhagic events and improved functional outcomes (p

Published
2015

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