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Start Over Author "Julie Vallortigara" Journal neurobiology of disease
2 results on '"Julie Vallortigara"'

1. T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior

Author

Julie Vallortigara, Serge Alfos, Jacques Micheau, Paul Higueret, and Valérie Enderlin

Subjects
Hypothyroidism, Adult, Striatum, Triiodothyronine nuclear receptors, Synaptic plasticity, Motor behavior, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Adult-onset hypothyroidism is associated with neurological changes such as cognitive dysfunction and impaired learning, which may be related to alterations of synaptic plasticity. We investigate the consequence of adult-onset hypothyroidism on thyroid-mediated transcription events in striatal synaptic plasticity, and the effect of triiodothyronine (T3) replacement. We used hypothyroid mice, treated with propylthiouracil (PTU) and methimazole (MMI), with or without subsequent administration of T3. We evaluated the amount of T3 nuclear receptors (TRα1, TRβ) and striatal plasticity indicators: neurogranin (RC3), Ras homolog enriched in striatum (Rhes), Ca2+/calmodulin-dependent protein kinase (CaMKII), and dopamine- and cAMP-regulated phosphoprotein (DARPP-32). In addition, we assessed hypothyroid mice motor behavior as related to striatum synaptic functions. Hypothyroid mice exhibited significantly reduced TRβ, RC3 and Rhes expression. T3 administration reversed the expression of TRβ, RC3, and up-regulated CaMKII levels as well as motor behavior, and decreased DARPP-32 protein phosphorylation. We suggest that thyroid hormone modulation had a major impact on striatal synaptic plasticity of adult mice which produced in turn motor behavior modifications.

Published
2008
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2. T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior

Author

V Enderlin, Julie Vallortigara, Serge Alfos, Jacques Micheau, and Paul Higueret

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Dopamine and cAMP-Regulated Phosphoprotein 32, endocrine system diseases, Presynaptic Terminals, Thyroid Gland, Striatum, Biology, Motor Activity, Synaptic Transmission, Synaptic plasticity, lcsh:RC321-571, Mice, Hypothyroidism, Dopamine, GTP-Binding Proteins, Ca2+/calmodulin-dependent protein kinase, Internal medicine, Motor behavior, medicine, Animals, Neurogranin, Phosphorylation, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Triiodothyronine, Methimazole, Movement Disorders, Neuronal Plasticity, Receptors, Thyroid Hormone, Behavior, Animal, Triiodothyronine nuclear receptors, Age Factors, Corpus Striatum, Up-Regulation, Disease Models, Animal, Endocrinology, Neurology, Nuclear receptor, Propylthiouracil, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Biomarkers, medicine.drug
Abstract

article i nfo Adult-onset hypothyroidism is associated with neurological changes such as cognitive dysfunction and impaired learning, which may be related to alterations of synaptic plasticity. We investigate the consequence of adult-onset hypothyroidism on thyroid-mediated transcription events in striatal synaptic plasticity, and the effect of triiodothyronine (T3) replacement. We used hypothyroid mice, treated with propylthiouracil (PTU) and methimazole (MMI), with or without subsequent administration of T3. We evaluated the amount of T3 nuclear receptors (TRα1, TRβ) and striatal plasticity indicators: neurogranin (RC3), Ras homolog enriched in striatum (Rhes), Ca2+/calmodulin-dependent protein kinase (CaMKII), and dopamine- and cAMP- regulated phosphoprotein (DARPP-32). In addition, we assessed hypothyroid mice motor behavior as related to striatum synaptic functions. Hypothyroid mice exhibited significantly reduced TRβ, RC3 and Rhes expression. T3 administration reversed the expression of TRβ, RC3, and up-regulated CaMKII levels as well as motor behavior, and decreased DARPP-32 protein phosphorylation. We suggest that thyroid hormone modulation had a major impact on striatal synaptic plasticity of adult mice which produced in turn motor behavior modifications.

Published
2007

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