Search

Your search keyword '"Elbaz, Alexis"' showing total 8 results
Start Over Author "Elbaz, Alexis" Journal neurobiology of aging
8 results on '"Elbaz, Alexis"'

3. The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants

Author

Heckman, Michael G., Elbaz, Alexis, Soto-Ortolaza, Alexandra I., Serie, Daniel J., Aasly, Jan O., Annesi, Grazia, Auburger, Georg, Bacon, Justin A., Boczarska-Jedynak, Magdalena, Bozi, Maria, Brighina, Laura, Chartier-Harlin, Marie-Christine, Dardiotis, Efthimios, Destée, Alain, Ferrarese, Carlo, Ferraris, Alessandro, Fiske, Brian, Gispert, Suzana, Hadjigeorgiou, Georgios M., Hattori, Nobutaka, Ioannidis, John P.A., Jasinska-Myga, Barbara, Jeon, Beom S., Kim, Yun Joong, Klein, Christine, Kruger, Rejko, Kyratzi, Elli, Lin, Chin-Hsien, Lohmann, Katja, Loriot, Marie-Anne, Lynch, Timothy, Mellick, George D., Mutez, Eugénie, Opala, Grzegorz, Park, Sung Sup, Petrucci, Simona, Quattrone, Aldo, Sharma, Manu, Silburn, Peter A., Sohn, Young Ho, Stefanis, Leonidas, Tadic, Vera, Tomiyama, Hiroyuki, Uitti, Ryan J., Valente, Enza Maria, Vassilatis, Demetrios K., Vilariño-Güell, Carles, White, Linda R., Wirdefeldt, Karin, Wszolek, Zbigniew K., Wu, Ruey-Meei, Xiromerisiou, Georgia, Maraganore, Demetrius M., Farrer, Matthew J., and Ross, Owen A.

Published
2014
Full Text
View/download PDF

4. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease

Author

Sharma, Manu, Maraganore, Demetrius M., Ioannidis, John P.A., Riess, Olaf, Aasly, Jan O., Annesi, Grazia, Abahuni, Nadine, Bentivoglio, Anna Rita, Brice, Alexis, Van Broeckhoven, Christine, Chartier-Harlin, Marie-Christine, Destée, Alain, Djarmati, Ana, Elbaz, Alexis, Farrer, Matthew, Ferrarese, Carlo, Gibson, J. Mark, Gispert, Suzana, Hattori, Nobutaka, Jasinska-Myga, Barbara, Klein, Christine, Lesage, Suzanne, Lynch, Timothy, Lichtner, Peter, Lambert, Jean-Charles, Lang, Anthony E., Mellick, George D., De Nigris, Francesa, Opala, Grzegorz, Quattrone, Aldo, Riva, Chiara, Rogaeva, Ekaterina, Ross, Owen A., Satake, Wataru, Silburn, Peter A., Theuns, Jessie, Toda, Tatsushi, Tomiyama, Hiroyuki, Uitti, Ryan J., Wirdefeldt, Karin, Wszolek, Zbigniew, Gasser, Thomas, and Krüger, Rejko

Published
2011
Full Text
View/download PDF

5. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease

Author

Krüger, Rejko, Sharma, Manu, Riess, Olaf, Gasser, Thomas, Van Broeckhoven, Christine, Theuns, Jessie, Aasly, Jan, Annesi, Grazia, Bentivoglio, Anna Rita, Brice, Alexis, Djarmati, Ana, Elbaz, Alexis, Farrer, Matthew, Ferrarese, Carlo, Gibson, J. Mark, Hadjigeorgiou, Georgios M., Hattori, Nobutaka, Ioannidis, John P.A., Jasinska-Myga, Barbara, Klein, Christine, Lambert, Jean-Charles, Lesage, Suzanne, Lin, Juei-Jueng, Lynch, Timothy, Mellick, George D., de Nigris, Francesa, Opala, Grzegorz, Prigione, Alessandro, Quattrone, Aldo, Ross, Owen A., Satake, Wataru, Silburn, Peter A., Tan, Eng King, Toda, Tatsushi, Tomiyama, Hiroyuki, Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, and Maraganore, Demetrius M.

Published
2011
Full Text
View/download PDF

6. NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases

Author

Blauwendraat, Cornelis, primary, Faghri, Faraz, additional, Pihlstrom, Lasse, additional, Geiger, Joshua T., additional, Elbaz, Alexis, additional, Lesage, Suzanne, additional, Corvol, Jean-Christophe, additional, May, Patrick, additional, Nicolas, Aude, additional, Abramzon, Yevgeniya, additional, Murphy, Natalie A., additional, Gibbs, J. Raphael, additional, Ryten, Mina, additional, Ferrari, Raffaele, additional, Bras, Jose, additional, Guerreiro, Rita, additional, Williams, Julie, additional, Sims, Rebecca, additional, Lubbe, Steven, additional, Hernandez, Dena G., additional, Mok, Kin Y., additional, Robak, Laurie, additional, Campbell, Roy H., additional, Rogaeva, Ekaterina, additional, Traynor, Bryan J., additional, Chia, Ruth, additional, Chung, Sun Ju, additional, Hardy, John A., additional, Brice, Alexis, additional, Wood, Nicholas W., additional, Houlden, Henry, additional, Shulman, Joshua M., additional, Morris, Huw R., additional, Gasser, Thomas, additional, Krüger, Rejko, additional, Heutink, Peter, additional, Sharma, Manu, additional, Simón-Sánchez, Javier, additional, Nalls, Mike A., additional, Singleton, Andrew B., additional, and Scholz, Sonja W., additional

Published
2017
Full Text
View/download PDF

7. No evidence of a longitudinal association between diurnal cortisol patterns and cognition

Author

Singh-Manoux, Archana, Dugravot, Aline, Elbaz, Alexis, Shipley, Martin, Kivimaki, Mika, Kumari, Meena, Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ste Périne, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), This research is supported by the US National Institutes of Health(R01AG013196 to A. S-M, R01AG034454 toA. S-M and M.K, R01HL036310 toM. K), the UK Medical Research Council (K013351to M. K), the Economic and Social Research Council (toM. K) and the British Heart Foundation, which supportsM.J. S., Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and SZTAJNBOK, Pascale

Subjects
Male, Aging, Hypothalamo-Hypophyseal System, Time Factors, Hydrocortisone, Neuroscience(all), Clinical Neurology, Pituitary-Adrenal System, Cognitive decline, Cortisol, Cognition, Glucocorticoid, Humans, Longitudinal Studies, Saliva, Regular Article, Middle Aged, Circadian Rhythm, Ageing, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Geriatrics and Gerontology, Cognition Disorders, Developmental Biology
Abstract

International audience; We examined the effect of salivary cortisol on cognitive performance and decline in 3229 adults (79% men), mean age 61 years. Six saliva samples over the day along with a cognition test battery were administered twice in 5 years. In fully-adjusted cross-sectional analyses from 2002 to 2004, higher waking cortisol was associated with higher reasoning score (β = 0.08, 95% confidence interval: 0.01, 0.15) but this finding was not replicated using data from 2007 to 2009. Over the mean 5 years follow-up there was decline in all cognitive tests but this decline did not vary as a function of cortisol levels; the exception was among APOE e4 carriers where a flatter diurnal slope and higher bedtime cortisol were associated with faster decline in verbal fluency. Changes in cortisol measures between 2002/2004 and 2007/2009 or chronically elevated levels were not associated with cognitive performance in 2007/2009. These results, based on a large sample of community-dwelling adults suggest that variability in hypothalamic-pituitary-adrenal function is not a strong contributor to cognitive aging.

Published
2013

8. Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.

Author

Heckman MG, Elbaz A, Soto-Ortolaza AI, Serie DJ, Aasly JO, Annesi G, Auburger G, Bacon JA, Boczarska-Jedynak M, Bozi M, Brighina L, Chartier-Harlin MC, Dardiotis E, Destée A, Ferrarese C, Ferraris A, Fiske B, Gispert S, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lin CH, Lohmann K, Loriot MA, Lynch T, Mellick GD, Mutez E, Opala G, Park SS, Petrucci S, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Tomiyama H, Uitti RJ, Valente EM, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Xiromerisiou G, Maraganore DM, Farrer MJ, and Ross OA

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Asian People genetics, Female, Genotype, Haplotypes genetics, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Risk, White People genetics, Young Adult, Genetic Predisposition to Disease genetics, Genetic Variation, Parkinson Disease genetics, Parkinson Disease prevention & control, Protein Serine-Threonine Kinases genetics, alpha-Synuclein genetics, tau Proteins genetics
Abstract

The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (LRRK2) gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRRK2 p.R1398H across MAPT and SNCA variant genotypes has not been assessed. To address this, we examined 4 SNCA variants (rs181489, rs356219, rs11931074, and rs2583988), the MAPT H1-haplotype-defining variant rs1052553, and LRRK2 p.R1398H (rs7133914) in Caucasian (n = 10,322) and Asian (n = 2289) series. There was no evidence of an interaction of LRRK2 p.R1398H with MAPT or SNCA variants (all p ≥ 0.10); the protective effect of p.R1398H was observed at similar magnitude across MAPT and SNCA genotypes, and the risk effects of MAPT and SNCA variants were observed consistently for LRRK2 p.R1398H genotypes. Our results indicate that the association of LRRK2 p.R1398H with Parkinson's disease is independent of SNCA and MAPT variants, and vice versa, in Caucasian and Asian populations., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results