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Your search keyword '"De Deyn, Peter Paul"' showing total 18 results
Start Over Author "De Deyn, Peter Paul" Journal neurobiology of aging
18 results on '"De Deyn, Peter Paul"'

7. Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease

Author

BELNEU Consortium, Hoogmartens, Julie, Hens, Elisabeth, Engelborghs, Sebastiaan, De Deyn, Peter Paul, van der Zee, Julie, Van Broeckhoven, Christine, Cacace, Rita, Neurology, Clinical sciences, Neuroprotection & Neuromodulation, and BELNEU Consortium

Subjects
Adult, Male, 0301 basic medicine, Aging, MMP3, Candidate gene, MMP1, Mutation, Missense, Disease, Matrix metalloproteinase, Biology, Bioinformatics, Frameshift mutation, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Alzheimer Disease, Matrix Metalloproteinase 13, Aspartic Acid Endopeptidases, Humans, Missense mutation, Genetic Association Studies, Aged, Aged, 80 and over, Rare missense mutations, neurology, General Neuroscience, MMP13, matrix metalloproteinases, AD, Middle Aged, Alzheimer's disease, 030104 developmental biology, Female, Human medicine, Neurology (clinical), Amyloid Precursor Protein Secretases, Geriatrics and Gerontology, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Matrix metalloproteinases (MMPs) are a multigene family of proteinases regulating the functions of a large number of signaling and scaffolding molecules that are involved in neuro-inflammation, synaptic dysfunction and neuronal death. MMPs have been associated with neurological conditions, such as Alzheimer's disease (AD), through a sudden and massive upregulation of particular members of the MMP family. Evidence for this hypothesis can be found in the clinical observation of increased MMP1 and MMP3 expression levels in plasma of AD patients compared to control individuals and in the proamyloidogenic effects that have been described for additional MMP family members like MMP13, MT1-MMP, and MT5-MMP. Consequently, we investigated the role of MMP1, 3, 13, MT1-MMP, and MT5-MMP in the genetic etiology of AD. We performed full exonic resequencing of these 5 MMPs in 1278 AD patients (mean age at onset [AAO]: 74.88 I 9.10, range: 29-96) and 797 age-matched control individuals (mean age at inclusion [AAI]: 74.92 I 6.48, range: 65-100) from Flanders-Belgium and identified MMP13 as most promising candidate gene. We identified 6 ultra-rare (

Published
2021

10. PSP and small vessel disease: more than occasional co-occurence?

Author

Sieben, Anne, primary, Santens, Patrick, additional, Hemelsoet, Dimitri, additional, Engelborghs, Sebastiaan, additional, De Jonghe, Peter, additional, De Bleecker, Jan, additional, Maes, Jen, additional, Jadoul, Christina, additional, Cras, Patrick, additional, De Deyn, Peter-Paul, additional, Van Broeckhoven, Christine, additional, and Martin, Jean-Jacques, additional

Published
2016
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16. P4-033 Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia patients

Author

Engelborghs, Sebastiaan, primary, Dermaut, Bart, additional, Mariën, Peter, additional, Symons, Anoek, additional, Vloeberghs, Ellen, additional, Maertens, Karen, additional, Somers, Nore, additional, Goeman, Jos, additional, Rademakers, Roos, additional, Van Den Broeck, Marleen, additional, Pickut, Barbara A., additional, Cruts, Marc, additional, Van Broeckhoven, Christine, additional, and De Deyn, Peter Paul, additional

Published
2004
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