1. Common and rare variants in HFE are not associated with Parkinson's disease in Europeans
- Author
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Jose Luis Alcantud, Ziv Gan-Or, Ronald B. Postuma, Clara Ruz, Sara Bandres-Ciga, and Prabhjyot Saini
- Subjects
0301 basic medicine ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Aging ,Parkinson's disease ,Iron ,Sequencing data ,Locus (genetics) ,Genome-wide association study ,Disease ,White People ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Iron homeostasis ,Medicine ,Homeostasis ,Humans ,Genetic Testing ,Hemochromatosis Protein ,Gene ,Pathological ,Genetics ,business.industry ,General Neuroscience ,nutritional and metabolic diseases ,Genetic Variation ,Parkinson Disease ,medicine.disease ,Europe ,030104 developmental biology ,Logistic Models ,alpha-Synuclein ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Negative Results ,030217 neurology & neurosurgery ,Developmental Biology ,Genome-Wide Association Study - Abstract
A recent study suggested that the p.H63D variant in HFE, a gene involved in iron homeostasis, may modify α‐synuclein pathology, the pathological hallmark of Parkinson's disease (PD). If indeed this gene and specific variant are involved in PD, we expect to find differential distribution of HFE variants when comparing PD patients and controls. We analyzed genome-wide association study (GWAS) data from 14,671 PD patients and 17,667 controls and full sequencing data from additional 1647 PD patients and 1050 controls, using logistic regression models, and burden and Kernel tests. The HFE p.H63D variant was not associated with PD, nor did all the other common variants in the HFE locus. We did not find association of rare HFE variants with PD as well in all types of burden and Kernel tests. Our results do not support a role for HFE in PD risk.
- Published
- 2020