1. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors
- Author
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Chen, Hui, Thomas, Cheddhi, Munoz, Felipe Andres, Alexandrescu, Sanda, Horbinski, Craig M, Olar, Adriana, McGuone, Declan, Camelo-Piragua, Sandra, Wang, Lu, Pentsova, Elena, Phillips, Joanna, Aldape, Kenneth, Chen, Wen, Iafrate, A John, Chi, Andrew S, Zagzag, David, Golfinos, John G, Placantonakis, Dimitris G, Rosenblum, Marc, Ohman-Strickland, Pamela, Hameed, Meera, and Snuderl, Matija
- Subjects
Cancer ,Clinical Research ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Aneuploidy ,Brain Neoplasms ,Chemotherapy ,Adjuvant ,Child ,Chromosomal Instability ,Chromosome Deletion ,Chromosomes ,Human ,Pair 1 ,Chromosomes ,Human ,Pair 19 ,Female ,Humans ,In Situ Hybridization ,Fluorescence ,Isocitrate Dehydrogenase ,Male ,Middle Aged ,Neoadjuvant Therapy ,Neurosurgical Procedures ,Oligodendroglioma ,Prognosis ,Progression-Free Survival ,Radiotherapy ,Adjuvant ,Survival Rate ,Young Adult ,1p/19q codeletion ,glioma ,oligodendroglioma ,polysomy ,Neurosciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundChromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status.MethodsWe analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS).ResultsIn our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with
- Published
- 2019