Search

The article presents a study which establishes developmental neural tube defects model through administration of retinoic acid to pregnant rats. The study used gene chip hybridization analysis to determine the involvement of genes in the formation of developmental neural tube defects. Results showed that cell cycle-related genes p57kip2, Cdk5 and Spin play a significant role in neural tube defects formation.

The article focuses on the study which investigates the aquaporin 4 expression and the ultrastructure of the blood-brain barrier following cerebral contusion injury. Topics discussed include neural regeneration, brain injury, and brain edema. Also mentioned are laceration injury, brain capillary endothelial cells and astrocytes, and water transport.

The article discusses a study on genes involved in the regulation of embryonic cell development, which have to do with retinoic acid-induced neural tube defects in mice. The authors made a comparison of gene expression differences between normal and defective neural tubes at 9.5 and 10.5 days, which involved downregulation and upregulation of certain expressions, then confirmed results by Northern blot hybridization. Results suggested that expressions including Cdk5, Rb1, and Apoa-4 are important regulatory factors involved in neural tube defects.

The article discusses a study conducted in China which analyzed the effects of homocysteine on apoptosis, intracellular superoxide dismutase (SOD) activity, and malondialdehyde content in tissue surrounding hematoma in rats with cerebral hemorrhage. The study also determined the action pathway of malondialdehyde following cerebral hemorrhage. The results showed that homocysteine aggravates neurological dysfunction and brain edema in rats with cerebral hemorrhage.