1. A case of recurrent adrenocortical carcinoma, with observations on long-term o,p'-DDD therapy and complications.
- Author
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van Aalderen W, van Seters AP, Backer ET, Chang PC, van Krieken JH, and Moolenaar AJ
- Subjects
- Adrenal Gland Neoplasms pathology, Carcinoma pathology, Carcinoma secondary, Carcinosarcoma pathology, Combined Modality Therapy, Female, Humans, Lung Neoplasms secondary, Lung Neoplasms therapy, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasms, Second Primary, Ovarian Neoplasms pathology, Time Factors, Adrenal Gland Neoplasms therapy, Carcinoma therapy, Mitotane therapeutic use, Neoplasm Recurrence, Local therapy
- Abstract
This report describes a patient with a recurring, one stemline-aneuploid, adrenocortical carcinoma. The condition showed a number of unusual characteristics over a period of 22 yr. It changed from a biochemically functioning, low-grade malignant tumour into a non-functioning malignancy with pronounced mitotic activity, accompanied by an ovarian carcinosarcoma 1 yr before death. Quality of life was reasonable for many years despite chemotherapy, consisting of a total of almost 10 kg of o,p'-DDD administered over a period of 8 yr, and the subsequent side effects (e.g. low T4; increased bleeding time). A reduced mineralocorticoid activity, induced by o,p'-DDD, was reversed after discontinuation of o,p'-DDD treatment. During o,p'-DDD administration the substitution requirements for both hydrocortisone and fludrocortisone acetate increased, leading to periods of hypoadrenocorticism with prerenal uraemia.
- Published
- 1992