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Start Over Author "Sung Hak Kang" Journal nephron clinical practice
4 results on '"Sung Hak Kang"'

1. Upregulation of Thymidine Phosphorylase in Chronic Glomerulonephritis and Its Role in Tubulointerstitial Injury

Author

Cho Hyun Park, Kweon-Heang Lee, Chang Suk Kang, Eun-Hui Wang, Yong Bok Goh, In Sung Moon, Sung Hak Kang, and Yeong Jin Choi

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Pathology, Angiogenesis, Inflammation, In situ hybridization, Glomerulonephritis, Fibrosis, Internal medicine, medicine, Humans, Thymidine phosphorylase, Thymidine Phosphorylase, Neovascularization, Pathologic, business.industry, General Medicine, Middle Aged, medicine.disease, Up-Regulation, Endocrinology, Chronic Disease, Disease Progression, Female, medicine.symptom, business, Kidney disease
Abstract

Chronic tubulointerstitial injury (CTI), commonly a sequel to chronic glomerulonephritis (CGN), is associated with the proliferation of new blood vessels. Angiogenesis is an essential process in chronic inflammation, and is controlled by a number of angiogenic factors including thymidine phosphorylase (TP). Knowledge of TP in renal disease is still rudimentary, and its role in CGN has not been explored. We analyzed the expression of TP by RTPCR, immunohistology and in situ hybridization in 20 human kidneys with CGN. To evaluate the degree of angiogenesis, we counted the microvessel density (MVD). MVD was significantly higher in all categories of CGN, between 19.7 ± 7.7 and 58.9 ± 7.5, compared to control value, 12.7 ± 5.0 (p< 0.05). MVD was increased in areas of abundant mononuclear cell infiltration with minimal interstitial fibrosis, and decreased or absent in areas of marked fibrosis. There was a significant correlation between MVD and interstitial fibrosis (p < 0.0001). TP mRNA was upregulated for all categories of CGN. TP was strongly expressed by mononuclear inflammatory cells and in most atrophic tubules. Each MVD and interstitial volume was significantly correlated with both the number of TP+ mononuclear cells and TP+ tubular cells, respectively (p < 0.0001). We have demonstrated an upregulation of TP and increase in MVD in areas of CTI in a variety of CGN. The up-regulation of TP may contribute to angiogenesis, which may play a critical role in the progression of interstitial fibrosis in CGN.

Published
2005

2. Contents Vol. 102, 2006

Author

Koichi Matsumoto, Lavern M. Vercaigne, Juan Schropp, Yasuo Imanishi, Kaname Hirowatari, Cho Hyun Park, Atsushi Satomura, Jukka Mustonen, David M. Collins, Yong Bok Goh, Juhani Myllymäki, Morito Endo, Byoung-Soo Cho, Hernán Trimarchi, Maria Koukoulaki, Eun-Hui Wang, Keevin Bernstein, Colette B Raymond, Takao Tsuchida, Betul Kalender, Sung Hak Kang, Emilio Freixas, Pablo Young, Takayuki Fujita, Mariano Forrester, David Jayne, Sung-Do Kim, Yeong Jin Choi, Naoki Matsumoto, Chang Suk Kang, Amos Pasternack, Dan E. Skwarchuk, Hiroyuki Ohi, Sukemasa Sudo, Misao Matsushita, Masaaki Inaba, Kweon-Heang Lee, Heikki Saha, Heikki Helin, Takami Miki, Aytul Corapcioglu Ozdemir, Yoshinobu Fuke, In Sung Moon, Shuichi Jono, Yoshiki Nishizawa, Teizo Fujita, Eiji Ishimura, Gulturk Koroglu, Horacio Pereyra, and Isao Ohsawa

Subjects
Traditional medicine, Nephrology, business.industry, Medicine, General Medicine, business
Published
2006

3. Subject Index Vol. 102, 2006

Author

Hiroyuki Ohi, Juan Schropp, Koichi Matsumoto, Kaname Hirowatari, Hernán Trimarchi, Gulturk Koroglu, Keevin Bernstein, Amos Pasternack, Colette B Raymond, Takao Tsuchida, Mariano Forrester, Yong Bok Goh, Takami Miki, Eun-Hui Wang, Isao Ohsawa, Misao Matsushita, Aytul Corapcioglu Ozdemir, Jukka Mustonen, Juhani Myllymäki, Takayuki Fujita, Yoshinobu Fuke, Masaaki Inaba, Heikki Helin, Chang Suk Kang, Yasuo Imanishi, Sukemasa Sudo, Dan E. Skwarchuk, Sung-Do Kim, Byoung-Soo Cho, Horacio Pereyra, Morito Endo, Sung Hak Kang, Teizo Fujita, Betul Kalender, Naoki Matsumoto, Kweon-Heang Lee, David M. Collins, Eiji Ishimura, Pablo Young, Lavern M. Vercaigne, Maria Koukoulaki, Cho Hyun Park, In Sung Moon, Shuichi Jono, Emilio Freixas, Yoshiki Nishizawa, David Jayne, Atsushi Satomura, Yeong Jin Choi, and Heikki Saha

Subjects
Index (economics), Nephrology, business.industry, Statistics, Medicine, Subject (documents), General Medicine, business
Published
2006

4. Upregulation of Thymidine Phosphorylase in Chronic Glomerulonephritis and Its Role in Tubulointerstitial Injury.

Author

Eun-Hui Wang, Yong Bok Goh, In Sung Moon, Cho Hyun Park, Kweon-Heang Lee, Sung Hak Kang, Chang Suk Kang, and Yeong-Jin Choi

Subjects
THYMIDINE, GLOMERULONEPHRITIS, PHOSPHORYLASES, BLOOD vessels, NEOVASCULARIZATION, KIDNEY diseases, FIBROSIS
Abstract

Chronic tubulointerstitial injury (CTI), commonly a sequel to chronic glomerulonephritis (CGN), is associated with the proliferation of new blood vessels. Angiogenesis is an essential process in chronic inflammation, and is controlled by a number of angiogenic factors including thymidine phosphorylase (TP). Knowledge of TP in renal disease is still rudimentary, and its role in CGN has not been explored. We analyzed the expression of TP by RTPCR, immunohistology and in situ hybridization in 20 human kidneys with CGN. To evaluate the degree of angiogenesis, we counted the microvessel density (MVD). MVD was significantly higher in all categories of CGN, between 19.7 ± 7.7 and 58.9 ± 7.5, compared to control value, 12.7 ± 5.0 (p< 0.05). MVD was increased in areas of abundant mononuclear cell infiltration with minimal interstitial fibrosis, and decreased or absent in areas of marked fibrosis. There was a significant correlation between MVD and interstitial fibrosis (p < 0.0001). TP mRNA was upregulated for all categories of CGN. TP was strongly expressed by mononuclear inflammatory cells and in most atrophic tubules. Each MVD and interstitial volume was significantly correlated with both the number of TP+ mononuclear cells and TP+ tubular cells, respectively (p < 0.0001). We have demonstrated an upregulation of TP and increase in MVD in areas of CTI in a variety of CGN. The up-regulation of TP may contribute to angiogenesis, which may play a critical role in the progression of interstitial fibrosis in CGN. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2006
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