7 results on '"Stefano Stuard"'
Search Results
2. Calcium Acetate/Magnesium Carbonate and Cardiovascular Risk Factors in Chronic Hemodialysis Patients
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Célia Gil, Cristina Jorge, Tiago Amaral, Inês Aires, Marco Mendes, Ana Azevedo, Patrícia Matias, Carina Ferreira, Aníbal Ferreira, David Navarro, Ivo Laranjinha, and Stefano Stuard
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medicine.drug_class ,medicine.medical_treatment ,Cardiovascular risk factors ,030232 urology & nephrology ,chemistry.chemical_element ,Acetates ,030204 cardiovascular system & hematology ,Pharmacology ,Calcium ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Risk Factors ,medicine ,Humans ,Magnesium ,Chronic hemodialysis ,Prospective Studies ,Aged ,Aged, 80 and over ,business.industry ,Calcium Compounds ,Middle Aged ,Phosphate binder ,chemistry ,Biochemistry ,Cardiovascular Diseases ,Calcium acetate/magnesium carbonate ,Hemodialysis ,business ,medicine.drug - Abstract
Background/Aim: Calcium acetate/magnesium carbonate (CaMg) is a recent phosphate binder that has been shown to have protective cardiovascular (CV) effects in animal models. The aim of this study was to evaluate the relationship between CaMg therapy and CV risk markers like pulse pressure (PP), left ventricular mass index (LVMI) and valvular calcifications compared to sevelamer or no phosphate binder (NPB) therapy in chronic hemodialysis (HD) patients. Methods: We performed a 48-month prospective study in 138 HD patients under hemodiafiltration with a dialysate Mg concentration of 0.5 mmol/l. Patients underwent treatment with CaMg or sevelamer for at least 36 months or NPB therapy. Demographic, clinical, biochemical and echocardiographic parameters were evaluated at baseline and after a 48-month period. Results: At the end of the study, patients who had taken CaMg showed a significant reduction in PP (p < 0.001), LVMI (p = 0.003), aortic (p = 0.004) and mitral valve calcifications (p = 0.03) compared with NPB patients. Patients under CaMg showed a significant reduction of PP (p < 0.001), LVMI (p = 0.01) and aortic valve calcifications (p = 0.02) compared to sevelamer patients. In a multivariable analysis, CaMg therapy was negatively associated with progression of LVMI (p = 0.02) and aortic valve calcifications (p = 0.01). Patients under CaMg showed higher serum Mg levels (0.93 ± 0.14 mmol/l) compared to patients under sevelamer (0.87 ± 0.13) or NPB patients (0.82 ± 0.12; p < 0.001). Conclusions: In prevalent HD patients, the use of CaMg over 48 months was associated with a reduction of PP and LVMI and with a stabilization of aortic valve calcifications. These protective and promising results of this new phosphate binder need to be confirmed in randomized controlled studies.
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- 2016
3. Contents Vol. 132, 2016
- Author
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Inês Aires, Stefano Stuard, Jianhua Mao, Huijun Shen, Burak Çağlayan, Cristina Jorge, David Navarro, Xiaoqiang Ding, Tiago Amaral, Marco Mendes, Gülderen Yanıkkaya, Ning Xue, Fulya Cakalagaoglu, Jie Teng, Carina Ferreira, Aimin Liu, Jale Çoban, Timothy J. Pianta, Yi Fang, Ertugrul Kilic, Zoltan H. Endre, Tuba Akdeniz, Mustafa Çağlar Beker, Zehra Eren, Patrícia Matias, Xiaoyan Zhang, Gulcin Kantarci, Druckerei Stückle, Aníbal Ferreira, Mehmet Yalçın Günal, Célia Gil, Ana Azevedo, Qiang Shu, John W. Pickering, Elif Ari, Kezhen Tong, Haidong Fu, Ivo Laranjinha, and Lizhong Du
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Traditional medicine ,business.industry ,Medicine ,business - Published
- 2016
4. Serum Levels of Soluble Adhesion Molecules in Chronic Renal Failure and Dialysis Patients
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Stefano Stuard, Patrizia Santarelli, Nicola Settefrati, Alberto Albertazzi, Marcella Reale, and Mario Bonomini
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Adult ,Male ,medicine.medical_specialty ,P-selectin ,medicine.medical_treatment ,Vascular Cell Adhesion Molecule-1 ,Enzyme-Linked Immunosorbent Assay ,Peritoneal dialysis ,chemistry.chemical_compound ,Peritoneal Dialysis, Continuous Ambulatory ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Dialysis ,Aged ,Aged, 80 and over ,Creatinine ,Blood Cells ,business.industry ,Cell adhesion molecule ,Continuous ambulatory peritoneal dialysis ,Soluble cell adhesion molecules ,Middle Aged ,Intercellular Adhesion Molecule-1 ,P-Selectin ,Endocrinology ,chemistry ,Immunology ,Kidney Failure, Chronic ,Female ,Hemodialysis ,business ,Cell Adhesion Molecules - Abstract
Besides cell-bound adhesion molecules, which are of fundamental importance to a large number of physiological and pathological processes, soluble forms of adhesion molecules have been detected in the circulating blood in recent years. Circulating soluble adhesion molecules appear to be biologically active, and raised levels have been reported in a variety of disorders. In the present study, we used ELISA to measure the serum levels of four soluble adhesion molecules in 23 undialyzed patients with chronic renal failure (CRF), 13 patients on continuous ambulatory peritoneal dialysis (CAPD), 17 on chronic hemodialysis (HD) and 18 healthy controls having a similar mean and distribution of ages. The investigated soluble (s) molecules included intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1), sE-selectin and sP-selectin. sICAM-1 was found to be elevated in patients with CRF (p < 0.05), on CAPD (p < 0.02) and HD (p < 0.0001) compared with the controls but levels did not differ between the three patient groups. The higher sVCAM-1 values found in CRF (p < 0.02), CAPD (p < 0.05) and HD (p < 0.0001) as compared to controls again failed to differentiate the three groups of patients. Soluble E-selectin was also raised in the three groups (p < 0.0001) with no difference between them. Increased sP-selectin was found in CRF (p < 0.05), CAPD (p < 0.02) and in HD patients (p < 0.0001) compared to controls, and levels in HD were significantly higher (p < 0.02) than in CRF patients. Predialysis serum molecule levels did not differ between HD patients treated with cuprophan or with polyacrylonitrile dialyzers. HD sessions with both dialyzers had no effect on sICAM-1, while a decrease (p < 0.02) in sP-selectin was found after dialysis with cuprophan. In undialyzed patients with CRF, regression analysis showed a strong linear correlation between serum creatinine and serum levels of each soluble molecule. These results demonstrate that serum levels of soluble adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin are elevated in both undialyzed patients with CRF and patients on CAPD or HD. The elevated serum levels of these proteins probably reflect inadequate clearance as well as enhanced synthesis/release.
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- 1998
5. Contents, Vol. 75, 1997
- Author
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Alison MacLeod, Kumeo Ono, Rida Bitar, Ivan Rychlik, Neva E. Haites, Gert Jensen, Jan Těmínová, B.A.C. Van Acker, Yoshio Suzuki, Akiyasu Tsutida, Kazuo Kumano, A.M. Brownjohn, Yoshikazu Hayashi, Tokuhiro Okada, Hye Won Park, Karel Němeček, Kazuto Inose, Yong Choi, Masakazu Fukuda, Hans Hedenström, Yoshio Ueno, Crkovská J, G.C.M. Koomen, M. Itoh, Mitsuhiro Matsuda, Hae Il Cheong, T. Sato, Tadasu Sakai, Marie Urabe, Il Soo Ha, S. Fletcher, Tadanobu Goya, Hisashi Hashimoto, Göran Wegenius, Minoru Komai, Belen Martín, Fumihiko Hinoshita, Y. Takemoto, Yasushi Isami, Visith Sitprija, Fumiaki Marumo, Hikaru Sugimoto, Robert Mlynski, Jong Kwan Jun, Mario Bonomini, Makoto Haga, S. Inomata, John Simpson, J.E. Aaron, HyungNam Moon, Kiyosi Uehara, Poledne R, R.G. Jones, M.S. Oh, J.W. Groothoff, M. Niwa, Takuji Naruse, H. Edney, S. Shaldon, Tsukasa Nakamura, M.L. Halperin, M. Tsuchiya, B. Oldroyd, Masayuki Onai, Björn Wikström, Shintaro Yano, Yasuhiko Tomino, Vladimír Tesař, Virat Vattanavongs, Stanislav Štípek, Hirofumi Makino, Shigeo Tomura, Graham S. Hillis, George Metry, Kwang Wook Ko, P.C. Wever, Kenichi Shikata, Gakusen Nishihara, P. Harnden, Tomáš Zima, Kenzo Matsuo, Marie-Paule Carreno, Kazuhito Takeda, Neil G. McKay, Yasushi Shikata, Isao Ebihara, José M. López-Novoa, T. Kishimoto, Chikao Yasunaga, L. Arisz, L.D. Hordon, Akira Yamada, Zensuke Ota, H.C. Rayner, Toru Hyodo, Juan F. Macías-Nuñez, Hikaru Koide, Lesley A. Duthie, Takanobu Sakemi, K. Tsuchida, Bo G. Danielson, Keitaro Yokoyama, B. Buis, Sanjay Mistry, Nicole Haeffner-Cavaillon, J.H. Turney, Masahiko Kushiro, Shigeko Hara, R.T. Krediet, Yosuke Ogura, Masahiko Nakamoto, M.A. Smith, Miroslav Merta, S. Yamagami, Patrizia Santarelli, Kenji Akiyama, Nicola Settefrati, Mattias Aurell, Stefano Stuard, Pláteník J, H. Imai, Alberto Albertazzi, and Tongprakob Siriwanij
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Traditional medicine ,Nephrology ,business.industry ,Medicine ,General Medicine ,business - Published
- 1997
6. Neutrophil Reactive Oxygen Species Production during Hemodialysis: Role of Activated Platelet Adhesion to Neutrophils through P-Selectin
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Stefano Stuard, Nicole Haeffner-Cavaillon, Marie-Paule Carreno, Alberto Albertazzi, Mario Bonomini, Patrizia Santarelli, and Nicola Settefrati
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Adult ,medicine.medical_specialty ,P-selectin ,Neutrophils ,Neutrophile ,medicine.medical_treatment ,In Vitro Techniques ,chemistry.chemical_compound ,Platelet Adhesiveness ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Platelet ,Cellulose ,Hydrogen peroxide ,chemistry.chemical_classification ,Reactive oxygen species ,business.industry ,Cuprophane ,Membranes, Artificial ,Hydrogen Peroxide ,General Medicine ,Middle Aged ,Flow Cytometry ,Oxidants ,Adenosine Diphosphate ,P-Selectin ,Endocrinology ,chemistry ,Nephrology ,Immunology ,Hemodialysis ,Reactive Oxygen Species ,Dialysis (biochemistry) ,business - Abstract
Platelet interaction with leukocytes can occur to a significant degree during hemodialysis, but it remains to be determined what pathophysiological consequences stem from the intradialytic formation of platelet-leukocyte coaggregates. By the use of flow cytometry techniques, this study was set out to analyze intradialytic platelet-neutrophil coaggregate formation and neutrophil hydrogen peroxide production from 10 end-stage renal disease patients each dialyzed with cuprophane and polyacrylonitrile membranes. Platelet-neutrophil coaggregates increased during dialysis with cuprophane, whereas no changes occurred with polyacrylonitrile membranes. Dialysis with cuprophane, unlike that with polyacrylonitrile, also resulted in a significant increase in neutrophil hydrogen peroxide production 10 min after dialysis initiation which persisted at significantly higher levels than predialysis values through the first 20 min. We found that the increased hydrogen peroxide production by neutrophils essentially occurred in concomitance with neutrophil-platelet coaggregation. Intracellular fluorescence representing hydrogen peroxide formation significantly increased through the first 20 min of cuprophane dialysis in neutrophils aggregated to platelets. By contrast, no change occurred in neutrophils not aggregated to platelets. Neutrophils which had formed aggregates with platelets produced higher hydrogen peroxide levels, as assessed by significantly higher fluorescence values, than non-aggregate-forming neutrophils at all time points tested. The phenomenon was duplicated in vitro when ADP-activated normal platelets were incubated with neutrophil cells but was largely inhibited when ADP-activated platelets were treated with anti-P-selectin antibody before incubation with neutrophils. These results strongly suggest that platelet-neutrophil aggregates occurring during hemodialysis, representing cell-cell interactions with pathophysiological effects, may serve as a new parameter to assess biocompatibility.
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- 1997
7. Subject Index Vol. 75, 1997
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Akiyasu Tsutida, Kazuo Kumano, John Simpson, Y. Takemoto, Tongprakob Siriwanij, Stanislav Štípek, Virat Vattanavongs, Fumihiko Hinoshita, Yoshio Suzuki, H.C. Rayner, Graham S. Hillis, Isao Ebihara, Hikaru Koide, George Metry, Belen Martín, Keitaro Yokoyama, Alison MacLeod, HyungNam Moon, Jan Těmínová, A.M. Brownjohn, J.E. Aaron, Ivan Rychlik, J.W. Groothoff, G.C.M. Koomen, Il Soo Ha, Hirofumi Makino, Yoshikazu Hayashi, Takanobu Sakemi, Bo G. Danielson, M.A. Smith, Minoru Komai, R.T. Krediet, Yosuke Ogura, Crkovská J, H. Edney, B.A.C. Van Acker, Kenzo Matsuo, Miroslav Merta, Tokuhiro Okada, S. Yamagami, Mitsuhiro Matsuda, Visith Sitprija, Karel Němeček, Takuji Naruse, S. Fletcher, R.G. Jones, Gert Jensen, Kwang Wook Ko, Shigeo Tomura, Tomáš Zima, Masayuki Onai, Zensuke Ota, Chikao Yasunaga, Akira Yamada, Hye Won Park, Lesley A. Duthie, Yasushi Isami, Björn Wikström, T. Sato, Fumiaki Marumo, Robert Mlynski, Shintaro Yano, Jong Kwan Jun, Mario Bonomini, Kiyosi Uehara, Toru Hyodo, B. Oldroyd, Göran Wegenius, M.S. Oh, Tsukasa Nakamura, Neil G. McKay, L.D. Hordon, Makoto Haga, Rida Bitar, Hae Il Cheong, M.L. Halperin, M. Niwa, Gakusen Nishihara, Sanjay Mistry, Kumeo Ono, Neva E. Haites, M. Itoh, Masahiko Nakamoto, Poledne R, K. Tsuchida, Nicole Haeffner-Cavaillon, J.H. Turney, Masahiko Kushiro, Shigeko Hara, Kazuto Inose, Yong Choi, P.C. Wever, Hans Hedenström, Tadanobu Goya, José M. López-Novoa, L. Arisz, B. Buis, M. Tsuchiya, S. Inomata, Juan F. Macías-Nuñez, Kenichi Shikata, Yoshio Ueno, Tadasu Sakai, S. Shaldon, Yasuhiko Tomino, Vladimír Tesař, Masakazu Fukuda, Patrizia Santarelli, Marie Urabe, Kenji Akiyama, Hisashi Hashimoto, Nicola Settefrati, Mattias Aurell, P. Harnden, Stefano Stuard, Pláteník J, H. Imai, Yasushi Shikata, T. Kishimoto, Alberto Albertazzi, Hikaru Sugimoto, Marie-Paule Carreno, and Kazuhito Takeda
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Index (economics) ,Nephrology ,business.industry ,Statistics ,Medicine ,Subject (documents) ,General Medicine ,business - Published
- 1997
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