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1. Direct Effect of Deferoxamine on Hemoglobin Synthesis in Patients on Hemodialysis Treated with Recombinant Human Erythropoietin

Author

R. Romero, R. Alonso, D. Novoa, D. Arza, S. Otero, Xosé M. Lens, V. Arcocha, M.C. Alonso, and D. Sanchez-Guisande

Subjects
medicine.medical_specialty, Anemia, Iron, Deferoxamine, Hematocrit, Hemoglobins, Renal Dialysis, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Erythropoietin, Mean corpuscular volume, Aged, Anemia, Hypochromic, biology, medicine.diagnostic_test, business.industry, Transferrin, Middle Aged, medicine.disease, Recombinant Proteins, Ferritin, Endocrinology, Ferritins, Immunology, biology.protein, Serum iron, Hemoglobin, business, Aluminum, circulatory and respiratory physiology, medicine.drug
Abstract

We have studied the response of hemoglobin (Hb), hematocrit, reticulocytes, mean corpuscular volume, ferritin, serum iron, total iron-binding capacity (TIBC) and the transferrin saturation index in 9 patients on chronic hemodialysis (HD) with minimal aluminum overload who were treated with recombinant human erythropoietin (rHuEPO) when a single dose of deferoxamine (DFO; 40 mg/kg b.w.) was administered. Analytical determinations were performed basally and 48 h, 7 days and 14 days after a DFO test. Hb increased from a basal value of 10 +/- 0.28 to 10.7 +/- 0.33 (p0.05), 10.4 +/- 0.33 (p0.05) and 10.1 +/- 0.31 g/dl (NS), respectively, and similar increases were seen with the hematocrit. Serum iron increased from 52 +/- 7.62 to 89.2 +/- 14.48 (p0.01), 94 +/- 18.73 (p0.01) and 85 +/- 14.01 micrograms/dl (p0.01), respectively. TIBC and ferritin did not change but the transferrin saturation index increased significantly. DFO produces an immediate improvement of the anemia in HD patients treated with rHuEPO and who have minimal aluminium accumulation: it should be related to an increased iron availability to erythroid precursors either releasing stored iron or decreasing aluminum-bound transferrin.

Published
1993
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2. Contents, Vol. 62, 1992

Author

Roscoe M. Moore, Marinus H. de Keijzer, Alison MacLeod, Chris E. Kaufman, Shigeaki Muto, Hikaru Koide, A. Oliet, Giorgio Annessi, R. Romero, M. Segasothy, Ronald G. Kaczmarek, P. Ronco, A. Notarbartolo, Sali Caglar, C.M. Barbagallo, Paola Omedè, William E. Nelson, Egidio Lusvarghi, Julie Piper, E. Barrio, Mayer Brezis, Iren B. Kovacs, L. Campanacci, Osman Özcebe, Stanford Hamburger, Gianna Mazzucco, Angela Recker, Shuichi Ishii, Tohru Yamaji, F. Mignon, C. Michel, J.L. Mahe, Neva E. Haites, M.A. Morel, Francesco Paolo Schena, Geoffrey M. Berlyne, Gobi Engler-Blum, J. Cledes, Eduardo H. Garin, Massimo Massaia, Teut Risler, Renate Klauser, J. Forteza, Ko Okumura, Cetin Turgan, Serafettin Kirazli, Giovanna Zambruno, S.R. Stella, Anthony E.G. Raine, Oktay Özdemir, Carlo Feletti, Antonio Amoroso, John Simpson, Kurt Widhalm, M. Bardelli, Freek J. Zijlstra, Monika Pergande, J.C. Bigot, Cristiana Rollino, Samuel N. Heyman, Yasushi Asano, Laurence R.I. Baker, S. Tomé Martínez de Rituerto, Anne Dieny, Beatriz Tucker, E. Vijaykumar, P.H. Ong, Semra Dündar, P. Dosquet, Dario Roccatell, Giuseppe Aimo, Stanley A. McMillan, Giuseppe Piccoli, Nicole Pinel, E. Hernández, Yoshihisa Itoh, J. Goffinet, Tadashi Kawai, Jean-Marc Weinstein, Erich Pohanka, Reinhold Deppisch, Vincenzo Montinaro, Claudia A. Müller, Teruyo Ozaki, Leopoldo Baldrati, A. Baraldi, M.I. Rodriguez, Martina Franz, Gerhard A. Müller, Mark Gruber, Claudia Capponcini, Nick Corontzes, Alan N. Charney, F. Fischetti, L. Furci, R. Carretta, M C Jones, Adalbert Bohle, Klaus Jung, O. Traindl, Josef Kovarik, V.E.R. Melhado, Peggy Hamilton, F. Vran, David A. Power, Fujiro Sendo, A. Vigil, Turgay Arinsoy, Rosanna Coppo, Bruno Watschinger, William Dickey, M.Y. Norazlina, Silvano Battaglio, V. Scafidi, Kyuzi Kamoi, Ryuta Okutani, Jean-Charles Renversez, Helmut Reichel, Daniel Cordonnier, Miyuki Ishibashi, L.G. Bardou, B. Mougenot, Wolfgang Kühn, C. Versolato, Hans Pidlich, Abraham P. Provoost, M. Jamil, S. Raziuddin, D. Sanchez-Guisande, A. Vasile, Ünal Yasavul, Prabir Roy-Chaudhury, A. Galione, Yasuhiko Tomino, Susan Reading, L.A. Moura, P. Gallar, Yutaka Yaguchi, Eberhard Ritz, Gina Mazzola, Kenneth G. Porter, M.-A. Bernard, Simon D. Roger, E.N. Wardle, Dino Docci, M.A. Boim, M.R. Averna, B. Viron, Thomas Kahn, N. Schor, S. Muiesan, Loreto Gesualdo, Elke Stier, D. Novoa, B. Fabris, Elisabetta Rubbiani, Jasmina Markovic-Lipkovski, François Le Marc’hadour, Claire M. Hill, Nurol Arik, and Mario Boccadoro

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1992
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3. Sialic acid is a predictor of cardiovascular complications in renal transplantation recipients

Author

V. Arcocha, Lucia Mouzo, Xosé M. Lens, R. Romero, D. Sanchez-Guisande, R. Alonso, D. Novoa, Manuel Paz, and María Dolores Arza Arza

Subjects
Adult, Male, medicine.medical_specialty, Arteriosclerosis, Urology, Nephropathy, chemistry.chemical_compound, medicine, Humans, Kidney, Tendo Calcaneus, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, N-Acetylneuraminic Acid, Sialic acid, Surgery, Transplantation, medicine.anatomical_structure, chemistry, Cardiovascular Diseases, Sialic Acids, Female, Complication, business
Published
1993

7. More about Renal Disease in Type la Glycogen Storage Disease

Author

E. Barrio, J. Forteza, R. Romero, M.I. Rodriguez, D. Novoa, S. Tomé Martínez de Rituerto, and D. Sanchez-Guisande

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, medicine, Glycogen storage disease, Disease, medicine.disease, business
Published
1992
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8. Subject Index, Vol. 62, 1992

Author

John Simpson, M. Jamil, William E. Nelson, S. Tomé Martínez de Rituerto, François Le Marc’hadour, L. Campanacci, Osman Özcebe, Gianna Mazzucco, Claire M. Hill, C.M. Barbagallo, A. Galione, Stanley A. McMillan, Yasuhiko Tomino, Stanford Hamburger, Paola Omedè, Rosanna Coppo, Jean-Charles Renversez, Nicole Pinel, Carlo Feletti, Marinus H. de Keijzer, M.Y. Norazlina, Samuel N. Heyman, Mark Gruber, Eduardo H. Garin, J. Cledes, F. Fischetti, E. Vijaykumar, Klaus Jung, Iren B. Kovacs, F. Mignon, O. Traindl, Turgay Arinsoy, Kenneth G. Porter, F. Vran, David A. Power, Tohru Yamaji, Alison MacLeod, Silvano Battaglio, Reinhold Deppisch, Kyuzi Kamoi, J.L. Mahe, Geoffrey M. Berlyne, Hikaru Koide, Mario Boccadoro, Gobi Engler-Blum, B. Mougenot, Cetin Turgan, J. Forteza, Serafettin Kirazli, Wolfgang Kühn, Claudia A. Müller, Chris E. Kaufman, Elisabetta Rubbiani, Erich Pohanka, Jasmina Markovic-Lipkovski, Nick Corontzes, L. Furci, R. Carretta, Peggy M. Hamilton, Anne Dieny, A. Notarbartolo, Sali Caglar, Leopoldo Baldrati, V. Scafidi, Helmut Reichel, Ryuta Okutani, Dario Roccatell, C. Versolato, Josef Kovarik, M. Segasothy, M C Jones, Yoshihisa Itoh, Hans Pidlich, Antonio Amoroso, A. Oliet, Abraham P. Provoost, Martina Franz, Vincenzo Montinaro, A. Vigil, Gina Mazzola, Miyuki Ishibashi, Fujiro Sendo, Kurt Widhalm, M.A. Boim, Simon D. Roger, A. Vasile, Nurol Arik, Prabir Roy-Chaudhury, D. Novoa, Mayer Brezis, Angela Recker, Giorgio Annessi, B. Viron, Thomas Kahn, M. Pergande, Yutaka Yaguchi, Eberhard Ritz, R. Romero, L. R. I. Baker, A. Baraldi, S. Raziuddin, Ko Okumura, N. Schor, Loreto Gesualdo, D. Sanchez-Guisande, Oktay Özdemir, S. Muiesan, M.I. Rodriguez, L.G. Bardou, Alan N. Charney, M.-A. Bernard, E. Hernández, Teruyo Ozaki, Roscoe M. Moore, Gerhard A. Müller, E.N. Wardle, S.R. Stella, Elke Stier, Dino Docci, Adalbert Bohle, M.R. Averna, Shigeaki Muto, Anthony E.G. Raine, B. Fabris, Semra Dündar, J. Goffinet, P. Dosquet, Bruno Watschinger, D. Cordonnier, M. Bardelli, C. Michel, Giovanna Zambruno, Ronald G. Kaczmarek, P.H. Ong, Tadashi Kawai, Jean-Marc Weinstein, J.C. Bigot, Giuseppe Piccoli, M.A. Morel, Francesco Paolo Schena, Yasushi Asano, P. Ronco, Egidio Lusvarghi, E. Barrio, William Dickey, Julie Piper, R. Klauser, Ünal Yasavul, Susan Reading, B. Tucker, L.A. Moura, P. Gallar, Claudia Capponcini, V.E.R. Melhado, Shuichi Ishii, Neva E. Haites, Massimo Massaia, Teut Risler, Freek J. Zijlstra, Cristiana Rollino, and Giuseppe Aimo

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1992
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9. HIV Infection and Renal Transplantation

Author

R. Romero, D. Novoa, D. Sanchez-Guisande, E. Carballo, and V. Arcocha

Subjects
Transplantation, medicine.medical_specialty, business.industry, Internal medicine, Human immunodeficiency virus (HIV), Medicine, business, medicine.disease_cause
Published
1989
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11. Sialic acid is a predictor of cardiovascular complications in renal transplantation recipients.

Author

Romero R, Lens XM, Novoa D, Arcocha V, Alonso R, Arza MD, Mouzo L, Paz M, and Sanchez-Guisande D

Subjects
Adult, Arteriosclerosis blood, Arteriosclerosis etiology, Female, Humans, Kidney Transplantation physiology, Male, Middle Aged, N-Acetylneuraminic Acid, Cardiovascular Diseases blood, Cardiovascular Diseases etiology, Kidney Transplantation adverse effects, Sialic Acids blood
Published
1993
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