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1. Urine Volume: Stone Risk Factor and Preventive Measure

Author

Angela Guerra, Almerico Novarini, Franca Allegri, Angelo Briganti, Tania Schianchi, Loris Borghi, and Tiziana Meschi

Subjects
Urinary volume, medicine.medical_specialty, Urine volume, business.industry, Urinary system, Drinking, Urine, medicine.disease, Surgery, Kidney Calculi, Fluid intake, Risk Factors, Existing Treatment, Emergency medicine, medicine, Humans, Calcium, Kidney stones, Risk factor, business, Kidney disease
Abstract

Background: A high fluid intake is the oldest existing treatment for kidney stones, and, up until a few decades ago, it was the only preventive measure at the physician’s disposal for stone recurrences. Methods: Using the data available in literature and partly unpublished personal research, we examine the role of urine volume as a stone risk factor, its impact on calcium crystallization mechanisms and its real importance as a means of prevention. Results: To sum up, the most important findings are: (1) a low urine volume must be considered as a real risk factor, both as regards the onset of renal calculi and stone relapses; (2) an increase in urine volume induced by a high water intake produces favourable effects on the crystallization of calcium oxalate and does not reduce the activity of natural inhibitors; (3) a sufficiently high intake of water and probably other fluids such as coffee, tea, beer and wine has a preventive effect on nephrolithiasis and its recurrence, and (4) the role of fruit juice is still to be defined. Conclusions: A high intake of fluids, especially water, is still the most powerful and certainly the most economical means of prevention of nephrolithiasis, and it is often not used to advantage by stone formers.

Published
1998

4. Which Antihypertensive Treatment in Renal Vasculitis?

Author

Almerico Novarini and Paolo Coruzzi

Subjects
medicine.medical_specialty, Kidney, Chemotherapy, Vascular disease, business.industry, medicine.medical_treatment, Lisinopril, Urology, medicine.disease, Nephropathy, medicine.anatomical_structure, Endocrinology, Internal medicine, Renin–angiotensin system, medicine, Amlodipine, Vasculitis, business, medicine.drug
Published
1992

5. Contents, Vol. 39, 1985

Author

N.C. Kramer, P. Bonvicini, Pedro Frommer, Loris Borghi, S. Dündar, Shaul G. Massry, J. Griño, Edwina A. Brown, J. Guéris, Naoyasu Sugishita, Yasuhito Saito, W. Kramer, Takao Suga, J.L. Sebert, Courtney Klingensmith, K.-G. Post, Kishore Phadke, P. Amodio, Anthony D. Nicastri, Edward T. Zawada, Donald I. Feinstein, T. Sözen, N D Markandu, M. Maxwell., A. Gatta, Jean-François de Frémont, Giorgio Graziani, J.E. McLure, T. Funke, A. Oktay, Masayuki Endoh, Laura W. Fleming, Akira Shinoda, L. S. Ibels, Murray Epstein, Diethard Gemsa, James B. Young, Anthony W. Stanson, Elettra Lorenzano, A. Schwarz, P.B. Bataille, A. Brulles, Jürgen Bommer, Isao Ishikawa, Claudio Ponticelli, M. Hervé, A. Fournier, Raymond F. Raper, Carlos Ayus, L. Dornfeld, Isabelle Grégoire, Julius M. Cruse, I. Grégoire, A.M. Thompson, Giuseppe A. Sagnella, Donald E. Engen, Isabella Simoni, A. Abraham, L. Milani, Rene Verberckmoes, M. Molzahn, J. Andreu, R. Romero, Ann James, M. Tuck, Nelly Ledême, W.K. Stewart, George P. Hemstreet, Wayne C. Waltzer, Robert B. Francis, Hirohisa Kitada, Rodger Loutzenhiser, Shizuko Suzuki, E. Ancona, Albert Fournier, Bruno Coevoet, Patrick Fievet, P. Morinière, Zengoro Onouchi, P. Rigotti, Geneviève Charransol, Paul Michielsen, Sylvester Sterioff, Ian C. Anderson, G. Bazzerla, J. Matin-Comin, Horst Zincke, C. Pagnini-Arslan, M.A. Oto, Eberhard Ritz, S. Dosa, P.J. Malony, L.O. Simpson, G. Schütterle, Pierre Bataille, Charles Horton, Josy Martens, Orlando Adamson, Myriam Finet, M. Johnson, Dilip Sen, T.M. Phillips, Alberto Cantaluppi, Graham A. MacGregor, Keita Tateishi, André Pruna, Hideto Sakai, F. Keller, Alberto Montanari, A. Caralps, Robert L. Chevalier, Glen L. Feye, A. Leflon, Rodney M. Sandier, Eben I. Feinstein, Anne A.A. Halliday, V. Wizemann, Daniel Levitan, Barbara E. Jones, Yoshihiro Fukuda, S. Arıoğul, Almerico Novarini, Joachim Kessler, C.K. Chen, Robert E. Lewis, Amir Tejani, and Didier Hauglustaine

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1985

6. Contents, Vol. 36, 1984

Author

Naoshi Kohrogi, Elisa Minelli Bertazzoni, P. Coruzzi, Rene Pelleya, L. Sánchez-Sicilia, P. Gómez-Fernández, J.S. Pierce, Keiichi Ito, Kimiyoshi Tsuji, Arthur H. Cohen, A.B. Geers, R. Selgas, J.T. Daugirdas, A. da Costa e Suva, Amin A. Nanji, Kazuro Kanatsu, Harry J. Ward, M. D’Amicone, Tetsuya Miyajima, W.J.F. van der Vijgh, Hiroki Tuchida, Takashi Kuwahara, O. Giardini, M.E. Martínez, M. Taccone-Gallucci, R. Lubrano, R. Coppo, C. Canavese, Jerry L. Newton, J.G. Martinelli, J.C. Netelenbos, Giovanni Panzetta, Jugoro Takeuchi, B. Basolo, A. Montero, James R. Oster, F.A.R. Neves, A. Vercellone, German Ramirez, A. Jonash, Hidehiko Kashiwabara, Frank H. Anderson, R.C.J. Ribeiro, E.J. Dorhout Mees, Toshio Doi, G. Ricciardi-Tenore, H. Boichis, D.J. Leehey, P.S.S. Beraldo, B. Seegal, G.P. Segoloni, Satoshi Akabane, C.U. Casciani, Patoula V. Caralis, Carl D. Brueggemeyer, E. Rossi, A. Borghetti, David C. Kem, G. Koren, U. Ruberto, F. Escuin, Minoru Kawamura, D. Bandino, Shigeo Tomura, J.M. Calatrava, L.O. Simpson, L. Musiari, L. Sánchez Agudo, S. Talarico, M. Aladjem, R.H. Albuquerque, P. Lips, Hideo Shishido, Shunichiro Sakurai, A. Novarini, M.J.M. Jongen, Guido O. Perez, S. Lamon, Wayne A. Border, Yoshihiro Hamashima, G. Piccoli, M.R. Bulzomi, I. Silvi, Koichi Ogino, H.A. Koomans, G.P. Campos, T.S. Ing, Hiroyuki Nagai, and J. Militiano

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1984

7. Low-Pressure Receptor Activity and Exaggerated Natriuresis in Essential Hypertension

Author

L. Musiari, S Tagliavini, A. Biggi, C. Ravanetti, Almerico Novarini, A Borghetti, E Lazzeroni, and Paolo Coruzzi

Subjects
Adult, Male, medicine.medical_specialty, Mean arterial pressure, Baroreceptor, Adolescent, Natriuresis, Hemodynamics, Blood Pressure, Pressoreceptors, Sodium Chloride, Essential hypertension, Heart Rate, Internal medicine, Immersion, medicine, Humans, Infusions, Parenteral, Plasma Volume, business.industry, Water, Middle Aged, medicine.disease, Endocrinology, Blood pressure, Pathophysiology of hypertension, Hypertension, Extracellular Space, Hypervolemia, business
Abstract

Urinary sodium excretion, central hemodynamics, and mean arterial pressure (MAP) were studied in 7 normal subjects and 19 hypertensive patients during both central hypervolemia by water immersion to the neck (NI) and extracellular volume expansion by i.v. saline infusion. During 2-hour NI, 12 out of the 19 hypertensives exhibited a significant fall in MAP (p less than 0.001). Exaggerated natriuresis did not occur in these patients (ns). In the remaining 7 hypertensive patients in whom, during NI, MAP was unchanged, exaggerated natriuresis was found (p less than 0.001). During saline infusion, MAP was either unchanged or increased and exaggerated natriuresis was found in all hypertensive patients (p less than 0.001) previously submitted to NI. Our findings suggest that a high MAP is a major determinant of exaggerated natriuresis in arterial hypertension.

Published
1985

8. Skeletal Muscle Water and Electrolytes in Chronic Renal Failure

Author

Almerico Novarini, Loris Borghi, Elettra Lorenzano, Alberto Montanari, Claudio Ponticelli, Isabella Simoni, A. Cantaluppi, and Giorgio Graziani

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Body water, Skeletal muscle, medicine.disease, Uremia, medicine.anatomical_structure, Endocrinology, Internal medicine, Extracellular fluid, medicine, Extracellular, Hemodialysis, business, Dialysis, Intracellular
Abstract

Skeletal muscle water, Cl, Na and K were studied in 24 patients with predialysis chronic renal failure (CRF) and in 16 patients under regular dialysis treatment (RDT) for 8-16 years; 35 healthy controls were also examined. Total Cl, Na and water (Clm, Nam, TW) were high in both CRF and RDT groups (p less than 0.001); high TW in CRF was due to both extra (ECW) and intracellular (ICW) fractions, which were calculated from Cl space; in RDT only ECW was increased and ICW was normal. Muscle K was diminished in CRF, in reference to both muscle fat free dry solids and ICW, and it was slightly but significantly higher than normal in RDT. The findings demonstrate that high cell volume and low intracellular K observed in CRF are fully corrected by long-term hemodialysis, probably because these abnormalities are mainly related to cell function disturbances due to uremic state. On the contrary, the persistence of high total Cl, Na and muscle ECW seems to be an expression of expanded extracellular fluid volume.

Published
1985

9. Glycolipid Modifications during Peritoneal Dialysis in Patients with Chronic Renal Failure

Author

A Cavatorta, Zuliani U, P Coruzzi, A. Bonetti, Caronna S, and Almerico Novarini

Subjects
Adult, Blood Glucose, medicine.medical_specialty, medicine.medical_treatment, Glycolipid metabolism, Peritoneal dialysis, Glycolipid, Internal medicine, medicine, Humans, Insulin, In patient, Dialysis, business.industry, Fatty Acids, General Medicine, Middle Aged, Endocrinology, Nephrology, Hyperglycemia, High glucose, Kidney Failure, Chronic, Chronic renal failure, Glycolipids, business, Peritoneal Dialysis
Abstract

Ten patients with progressive CRF were studied for the major indices of glycolipid metabolism during the first application of peritoneal dialysis. From the 2nd hour the concentration of dialysis fluid is 4.5g%, while the electrolyte content is unchanged. During treatment a constant increase of glycemia and insulinemia with a fall of plasma-free fatty acids and serum triglycerides was observed. The authors attribute such modifications to hyperglycemia and consequently to the high glucose of the dialysis bath.

Published
1976

10. Effects of ‘Central Hypervolemia’ by Water Immersion on Renin-Aldosterone System and ACTH-Cortisol Axis in Hemodialyzed Patients

Author

Almerico Novarini, Rossi E, A Borghetti, L. Musiari, and Paolo Coruzzi

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Sympathetic Nervous System, Hydrocortisone, Atrial Pressure, Pituitary-Adrenal System, Pressoreceptors, Blood volume, Renin-Angiotensin System, Adrenocorticotropic Hormone, Renal Dialysis, Dopamine, Internal medicine, Immersion, Renin–angiotensin system, medicine, Humans, Receptor, Uremia, Blood Volume, business.industry, Renin aldosterone system, medicine.disease, Endocrinology, Water immersion, business, Hypervolemia, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Water immersion up to the neck (WI) results in a central hypervolemia; the increased atrial pressure, evoked by this maneuver, stimulates low pressure receptors (LPR) which exert tonic inhibition on sympathetic activity and suppresses both the renin (PRA)-aldosterone (PA) system and the ACTH-cortisol axis in normal man. In hemodialyzed patients (HP), in whom autonomic neuropathy has been frequently found, PRA and ACTH were not suppressed during WI while plasma cortisol and PA were reduced. Other modulators, like dopamine, are supposed to be involved in regulating cortisol and PA levels in HP.

Published
1984

11. Skeletal muscle water and electrolytes in chronic renal failure. Effects of long-term regular dialysis treatment

Author

A, Montanari, G, Graziani, L, Borghi, A, Cantaluppi, I, Simoni, E, Lorenzano, C, Ponticelli, and A, Novarini

Subjects
Adult, Male, Time Factors, Muscles, Sodium, Hydrogen-Ion Concentration, Middle Aged, Water-Electrolyte Balance, Body Water, Chlorides, Renal Dialysis, Potassium, Humans, Kidney Failure, Chronic, Female, Extracellular Space
Abstract

Skeletal muscle water, Cl, Na and K were studied in 24 patients with predialysis chronic renal failure (CRF) and in 16 patients under regular dialysis treatment (RDT) for 8-16 years; 35 healthy controls were also examined. Total Cl, Na and water (Clm, Nam, TW) were high in both CRF and RDT groups (p less than 0.001); high TW in CRF was due to both extra (ECW) and intracellular (ICW) fractions, which were calculated from Cl space; in RDT only ECW was increased and ICW was normal. Muscle K was diminished in CRF, in reference to both muscle fat free dry solids and ICW, and it was slightly but significantly higher than normal in RDT. The findings demonstrate that high cell volume and low intracellular K observed in CRF are fully corrected by long-term hemodialysis, probably because these abnormalities are mainly related to cell function disturbances due to uremic state. On the contrary, the persistence of high total Cl, Na and muscle ECW seems to be an expression of expanded extracellular fluid volume.

Published
1985

15. Subject Index, Vol. 39, 1985

Author

Dilip Sen, Glen L. Feye, Ian C. Anderson, Eben I. Feinstein, M. Molzahn, J. Matin-Comin, Horst Zincke, P.J. Malony, Alberto Cantaluppi, Daniel Levitan, André Pruna, Shaul G. Massry, V. Wizemann, T.M. Phillips, Hideto Sakai, Isabella Simoni, Laura W. Fleming, Graham A. MacGregor, M. Tuck, Naoyasu Sugishita, E. Ancona, Hirohisa Kitada, Yoshihiro Fukuda, L.O. Simpson, Keita Tateishi, J.L. Sebert, T. Funke, Edwina A. Brown, J. Guéris, A.M. Thompson, Giuseppe A. Sagnella, Zengoro Onouchi, M. Hervé, Bruno Coevoet, Julius M. Cruse, Geneviève Charransol, A. Brulles, Diethard Gemsa, S. Arıoğul, Jürgen Bommer, Anthony W. Stanson, Elettra Lorenzano, George P. Hemstreet, R. Romero, Robert B. Francis, Masayuki Endoh, Charles Horton, Ann James, Josy Martens, Orlando Adamson, Carlos Ayus, A. Abraham, Nelly Ledême, J. Griño, Akira Shinoda, Donald E. Engen, M. Johnson, Rene Verberckmoes, J. Andreu, Paul Michielsen, Raymond F. Raper, Albert Fournier, L. Dornfeld, Anthony D. Nicastri, W. Kramer, Rodger Loutzenhiser, L. S. Ibels, Sylvester Sterioff, Shizuko Suzuki, F. Keller, Donald I. Feinstein, Claudio Ponticelli, G. Bazzerla, M.A. Oto, Isao Ishikawa, Eberhard Ritz, Patrick Fievet, S. Dosa, Pedro Frommer, Loris Borghi, G. Schütterle, P. Morinière, P. Rigotti, Myriam Finet, J.E. McLure, L. Milani, James B. Young, C. Pagnini-Arslan, S. Dündar, Pierre Bataille, K.-G. Post, A. Schwarz, Yasuhito Saito, Jean-François de Frémont, Isabelle Grégoire, T. Sözen, Takao Suga, N D Markandu, W.K. Stewart, Rodney M. Sandier, Wayne C. Waltzer, A. Gatta, Courtney Klingensmith, M. Maxwell., Kishore Phadke, Alberto Montanari, Edward T. Zawada, Barbara E. Jones, Giorgio Graziani, A. Oktay, Anne A.A. Halliday, Almerico Novarini, Robert L. Chevalier, A. Leflon, A. Caralps, A. Fournier, I. Grégoire, N.C. Kramer, P. Bonvicini, P. Amodio, Murray Epstein, P.B. Bataille, Joachim Kessler, C.K. Chen, Robert E. Lewis, Amir Tejani, and Didier Hauglustaine

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1985

16. Subject Index, Vol. 36, 1984

Author

B. Basolo, James R. Oster, W.J.F. van der Vijgh, German Ramirez, Hiroki Tuchida, Jerry L. Newton, Kazuro Kanatsu, J.G. Martinelli, Yoshihiro Hamashima, S. Talarico, M. Aladjem, P. Coruzzi, Arthur H. Cohen, R.H. Albuquerque, David C. Kem, G. Koren, J.S. Pierce, G.P. Segoloni, Hidehiko Kashiwabara, H.A. Koomans, D.J. Leehey, Patoula V. Caralis, M.J.M. Jongen, Guido O. Perez, S. Lamon, A. Vercellone, Frank H. Anderson, G.P. Campos, U. Ruberto, M. D’Amicone, C. Canavese, R.C.J. Ribeiro, T.S. Ing, L.O. Simpson, A.B. Geers, Amin A. Nanji, J.C. Netelenbos, L. Musiari, J.T. Daugirdas, A. Novarini, J.M. Calatrava, M.E. Martínez, Elisa Minelli Bertazzoni, Giovanni Panzetta, H. Boichis, Hideo Shishido, M. Taccone-Gallucci, Naoshi Kohrogi, Toshio Doi, L. Sánchez Agudo, Jugoro Takeuchi, Hiroyuki Nagai, Takashi Kuwahara, A. Montero, P.S.S. Beraldo, Satoshi Akabane, O. Giardini, Shunichiro Sakurai, Harry J. Ward, A. Jonash, Shigeo Tomura, I. Silvi, C.U. Casciani, Minoru Kawamura, J. Militiano, D. Bandino, E.J. Dorhout Mees, A. Borghetti, P. Lips, Wayne A. Border, Koichi Ogino, R. Selgas, F. Escuin, G. Ricciardi-Tenore, G. Piccoli, M.R. Bulzomi, Carl D. Brueggemeyer, R. Coppo, Keiichi Ito, A. da Costa e Suva, E. Rossi, Tetsuya Miyajima, R. Lubrano, Rene Pelleya, P. Gómez-Fernández, Kimiyoshi Tsuji, L. Sánchez-Sicilia, B. Seegal, and F.A.R. Neves

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1984

17. Urine volume: stone risk factor and preventive measure.

Author

Borghi L, Meschi T, Schianchi T, Briganti A, Guerra A, Allegri F, and Novarini A

Subjects
Calcium urine, Drinking, Humans, Risk Factors, Kidney Calculi prevention & control, Kidney Calculi urine, Urine physiology
Abstract

Background: A high fluid intake is the oldest existing treatment for kidney stones, and, up until a few decades ago, it was the only preventive measure at the physician's disposal for stone recurrences., Methods: Using the data available in literature and partly unpublished personal research, we examine the role of urine volume as a stone risk factor, its impact on calcium crystallization mechanisms and its real importance as a means of prevention., Results: To sum up, the most important findings are: (1) a low urine volume must be considered as a real risk factor, both as regards the onset of renal calculi and stone relapses; (2) an increase in urine volume induced by a high water intake produces favourable effects on the crystallization of calcium oxalate and does not reduce the activity of natural inhibitors; (3) a sufficiently high intake of water and probably other fluids such as coffee, tea, beer and wine has a preventive effect on nephrolithiasis and its recurrence, and (4) the role of fruit juice is still to be defined., Conclusions: A high intake of fluids, especially water, is still the most powerful and certainly the most economical means of prevention of nephrolithiasis, and it is often not used to advantage by stone formers.

Published
1999
Full Text
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18. Skeletal muscle water and electrolytes in chronic renal failure. Effects of long-term regular dialysis treatment.

Author

Montanari A, Graziani G, Borghi L, Cantaluppi A, Simoni I, Lorenzano E, Ponticelli C, and Novarini A

Subjects
Adult, Chlorides metabolism, Extracellular Space metabolism, Female, Humans, Hydrogen-Ion Concentration, Kidney Failure, Chronic therapy, Male, Middle Aged, Potassium metabolism, Sodium metabolism, Time Factors, Body Water metabolism, Kidney Failure, Chronic metabolism, Muscles metabolism, Renal Dialysis, Water-Electrolyte Balance
Abstract

Skeletal muscle water, Cl, Na and K were studied in 24 patients with predialysis chronic renal failure (CRF) and in 16 patients under regular dialysis treatment (RDT) for 8-16 years; 35 healthy controls were also examined. Total Cl, Na and water (Clm, Nam, TW) were high in both CRF and RDT groups (p less than 0.001); high TW in CRF was due to both extra (ECW) and intracellular (ICW) fractions, which were calculated from Cl space; in RDT only ECW was increased and ICW was normal. Muscle K was diminished in CRF, in reference to both muscle fat free dry solids and ICW, and it was slightly but significantly higher than normal in RDT. The findings demonstrate that high cell volume and low intracellular K observed in CRF are fully corrected by long-term hemodialysis, probably because these abnormalities are mainly related to cell function disturbances due to uremic state. On the contrary, the persistence of high total Cl, Na and muscle ECW seems to be an expression of expanded extracellular fluid volume.

Published
1985
Full Text
View/download PDF

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