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Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major postoperative complication that results in significant morbidity and mortality. Causes are heterogeneous, treatment strategies are largely supportive, and data on outcomes, such as potential for recovery, are lacking. This literature review explores the evidence on how furosemide may alter the course and outcome of postoperative fluid overload in patients with CSA-AKI. Nephrology nurse practitioners need to employ tailored preventive therapies at the preoperative, intraoperative, and postoperative points of care. This article discusses the unique methods for CSA-AKI mechanisms, hemodynamic monitoring strategies employed at the point of care recommended by clinical practice guidelines and recent evidence, and emerging biomarkers of AKI. Keywords: Acute kidney injury, acute kidney injury biomarkers, cardiac surgery-associated acute kidney injury, diuresis, furosemide., (NCPD) 1.3 contact hours Each year, more than 2 million cardiac surgeries are performed worldwide (National Heart, Lung, and Blood Institute, 2022). The incidence of acute kidney injury (AKI) following [...]