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Your search keyword '"Ramachandran, Raja"' showing total 20 results
Start Over Author "Ramachandran, Raja" Journal nephrology dialysis transplantation
20 results on '"Ramachandran, Raja"'

1. Memory B cells predict outcome in primary podocytopathies of adults.

Author

Bharati, Joyita, Das, Jhumki, Vignesh, Pandiarajan, Jhaveri, Kenar D, Prabhahar, Arun, Das, Chandan Krushna, Parihar, Anita Singh, Nada, Ritambhra, Ramachandran, Raja, Rawat, Amit, and Kohli, Harbir Singh

Subjects
IMMUNOLOGIC memory, FOCAL segmental glomerulosclerosis, B cells, NEPHROTIC syndrome, ADULTS, AUTOBIOGRAPHICAL memory
Abstract

This article examines the role of B cells in the development and treatment of primary podocytopathies, specifically minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). The study focuses on adults with new-onset nephrotic syndrome (NS) caused by primary podocytopathy and compares them to healthy controls. The findings indicate that B cell proportions differ between children and adults, and specific B cell subsets are associated with disease activity and predict response to steroid treatment. These findings have implications for targeted therapies for primary podocytopathies. However, more research is needed to confirm these results. [Extracted from the article]

Published
2023
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17. PLA2R antibodies, glomerular PLA2R deposits and variations inPLA2R1andHLA-DQA1genes in primary membranous nephropathy in South Asians

Author

Ramachandran, Raja, primary, Kumar, Vinod, additional, Kumar, Ashwani, additional, Yadav, Ashok Kumar, additional, Nada, Ritambhra, additional, Kumar, Harsha, additional, Kumar, Vivek, additional, Rathi, Manish, additional, Kohli, Harbir Singh, additional, Gupta, Krishan Lal, additional, Sakhuja, Vinay, additional, and Jha, Vivekanand, additional

Published
2015
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20. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.

Author

Ramachandran, Raja, Kumar, Vinod, Kumar, Ashwani, Yadav, Ashok Kumar, Nada, Ritambhra, Kumar, Harsha, Kumar, Vivek, Rathi, Manish, Kohli, Harbir Singh, Gupta, Krishan Lal, Sakhuja, Vinay, and Jha, Vivekanand

Subjects
*KIDNEY diseases, *PHOSPHOLIPASE A2, *ALLELES, *SOUTH Asians, *KIDNEY glomerulus, *HLA histocompatibility antigens, *DISEASES, *GENETICS
Abstract

Background. Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 genes are associated with PMN. Whether these alleles are associated with the development of anti-PLA2R is unknown. In this prospective study we evaluated anti-PLA2R, enhanced glomerular staining for PLA2R and variations in PLA2R1 and HLA-DQA1 genes in Indian patients with PMN and examined their association with response to treatment. Methods. A total of 114 adult PMN patients were studied. Anti-PLA2R was estimated before treatment and after 6 and 12 months of therapy. Enhanced glomerular staining for PLA2R was assessed on fresh frozen tissue. Genotype analysis was done on recruited patients and 95 healthy controls by Taq- Man assays for six single-nucleotide polymorphisms (SNPs; rs4664308, rs3749119, rs3749117, rs4664308, rs3828323 and rs2187668). Patients were followed up monthly for a period of 12 months. Results. Of 114 patients, 66.7% showed elevated serum anti- PLA2R by ELISA and 64.9% by indirect immunofluorescence. About 75% had enhanced glomerular staining for PLA2R. A total of 82% of patients had PLA2R-related disease. Reduction in serum anti-PLA2R titer had a significant association with remission of nephrotic syndrome (P = 0.0003) at 6 and 12 months. More than 85% of patients showing >90% reduction in the anti- PLA2R titer achieved remission of the nephrotic state, whereas of those showing <50% reduction in titers, 87.5% had persistent nephrotic state. The SNPs rs3749119, rs3749117, rs4664308 in PLA2R1 and rs2187668 in HLA-DQA1 were significantly associated with PMN. The SNP rs2187668 was associated with anti-PLA2R positivity. Patients with a high-risk genotype had higher anti-PLA2R levels. Conclusion. To conclude, anti-PLA2R and enhanced glomerular PLA2R staining are found in more than two-thirds of Indian PMN cases. A reduction in the anti-PLA2R titer correlated with response to therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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