1. The Association between Interleukin 10 Gene Polymorphism -592 (A/C) and Peritoneal Transport in Patients Undergoing Peritoneal Dialysis
- Author
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Ben-Chung Cheng, Jin-Bor Chen, Chih-Hsiung Lee, Yueh-Ting Lee, Yu-Kun Yang, Shang-Chih Liao, Chien-Te Lee, Kuo-Tai Hsu, Yu-Che Tsai, and Chien-Hsing Wu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Necrosis ,Genotype ,medicine.medical_treatment ,Taiwan ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Gastroenterology ,Permeability ,Peritoneal dialysis ,chemistry.chemical_compound ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Promoter Regions, Genetic ,Aged ,Retrospective Studies ,Creatinine ,Chi-Square Distribution ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Biological Transport ,General Medicine ,Odds ratio ,Middle Aged ,Interleukin-10 ,Logistic Models ,Phenotype ,Treatment Outcome ,chemistry ,Nephrology ,Immunology ,Kidney Failure, Chronic ,Female ,Gene polymorphism ,Peritoneum ,medicine.symptom ,business ,Peritoneal Dialysis - Abstract
Aim: The aim of this analysis was to know whether these three cytokine polymorphisms, including interleukin-6 (IL-6; −572 G/C), tumour necrosis factor-α (TNF-α; −308 G/A), and IL-10 (–592 A/C) have an effect on baseline peritoneal transport property and longitudinal evolution of peritoneal function. Methods: A total of 141 stable peritoneal dialysis (PD) patients with mean treatment duration of 84.4 ± 34.2 months were enrolled. We genotyped these three cytokine polymorphisms, together with clinical parameters that were included as factors affecting longitudinal change of property of peritoneal transport over the first 3 year period after commencing therapy. Results: There was no significant association between genotypes and baseline peritoneal transport property. The −592 A/C polymorphism of IL-10 was associated with longitudinal change of peritoneal transport. The ratio of D/P creatinine was significantly higher in patients with AA than those with CC/CA genotypes at 12 months (0.65 ± 0.11 vs 0.62 ± 0.09, P = 0.048) and 24 months (0.64 ± 0.12 vs 0.59 ± 0.09, P = 0.018). In addition, patients with increased peritoneal transport have greater frequency distribution of AA genotype and A allele. Logistic regression analysis revealed that −592 A allele was an independent predictor for the increase in D/P creatinine over the first 12 month period (odds ratio: 2.482, P = 0.017). There was no correlation between either polymorphism of IL-6 −572 (G/C) or TNF-α−308 (G/A) and longitudinal change of peritoneal function. Conclusions: Single nucleotide polymorphism of IL-10 −592 (A/C) was associated with longitudinal evolution of peritoneal transport rate in PD patients rather than the baseline peritoneal characteristics.
- Published
- 2011