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1. Chromosomal aberrations, sister chromatid exchanges and high frequency cells in young patients with neurofibromatosis 1 (NF1).

Author

Bigatti MP, Ardito G, Lamberti L, Crovella S, Collell M, Giordanino S, and Benso L

Subjects
Adolescent, Antimetabolites, Antineoplastic toxicity, Bleomycin toxicity, Child, Child, Preschool, Chromosome Fragility, Female, Humans, Infant, Male, Mitomycin toxicity, Neurofibromatosis 1 blood, Neurofibromatosis 1 pathology, Nucleic Acid Synthesis Inhibitors toxicity, Chromosome Aberrations, Neurofibromatosis 1 genetics, Sister Chromatid Exchange drug effects
Abstract

Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and high frequency cells (HFCs) have been assessed in peripheral blood lymphocytes of 10 neurofibromatosis (NF1) patients and 10 healthy controls. In both groups, the spontaneous rates and the induced (bleomycin for CA and MMC for SCE) frequencies were analyzed. No differences between cells from NF1 patients and controls were observed with respect to spontaneous or bleomycin induced CA. Spontaneous or MMC induced SCE frequencies were also similar in NF1 patients and controls. HFCs, on the contrary, were statistically lower in NF1 patients.

Published
2000

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