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Your search keyword '"Irmeli Nupponen"' showing total 3 results
Start Over Author "Irmeli Nupponen" Journal neonatology
3 results on '"Irmeli Nupponen"'

1. Increased Postnatal Inflammation in Mechanically Ventilated Preterm Infants Born to Mothers with Early-Onset Preeclampsia

Author

Irmeli Nupponen, Hannele Laivuori, Eero Kajantie, Sture Andersson, Heikki Repo, Sanna Siitonen, and R Turunen

Subjects
Adult, medicine.medical_specialty, Neutrophils, Birth weight, Gestational Age, Inflammation, Monocytes, Preeclampsia, Leukocyte Count, Obstetric Labor, Premature, Pre-Eclampsia, Pregnancy, medicine, Birth Weight, Humans, reproductive and urinary physiology, Phagocytes, Respiratory Distress Syndrome, Newborn, CD11b Antigen, Respiratory distress, biology, business.industry, Obstetrics, Early onset preeclampsia, C-reactive protein, Infant, Newborn, Gestational age, medicine.disease, Respiration, Artificial, female genital diseases and pregnancy complications, Fetal Diseases, C-Reactive Protein, Pediatrics, Perinatology and Child Health, biology.protein, Premature Birth, Female, medicine.symptom, business, Infant, Premature, Developmental Biology
Abstract

Background: Preeclampsia and preterm labor often underlie preterm birth, and are associated with maternal inflammation. In preterm infants, respiratory distress syndrome (RDS) and mechanical ventilation are associated with systemic inflammation. Objective: We aimed to study whether early-onset preeclampsia or preterm labor modulate the systemic inflammation affecting preterm infants with RDS. Methods: We recruited mechanically ventilated infants with gestational ages Results: As compared with infants born after preterm labor, infants born after early-onset preeclampsia had higher CD11b expression on days 1–6 on both neutrophils and monocytes. In addition, infants born after early-onset preeclampsia had higher CRP concentrations on days 2–6 (all p < 0.05). Conclusions: As compared with infants born after preterm labor to mothers without preeclampsia, infants born after early-onset preeclampsia presented with a stronger postnatal systemic inflammatory reaction. Antenatal exposure to preeclampsia may induce fetal leukocyte priming and regulation of inflammation, and thereby modify postnatal inflammatory reactions and morbidity.

Published
2011

2. Activation of T cells in preterm infants with respiratory distress syndrome

Author

Irmeli Nupponen, Outi Vaarala, Heikki Repo, Riikka Turunen, Sanna Siitonen, Sture Andersson, Aulikki Lano, and Eero Kajantie

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_treatment, T-Lymphocytes, Gestational Age, Adaptive Immunity, Systemic inflammation, Lymphocyte Activation, Flow cytometry, Medicine, Humans, L-Selectin, Bronchopulmonary Dysplasia, Mechanical ventilation, Respiratory Distress Syndrome, Newborn, medicine.diagnostic_test, Respiratory distress, business.industry, Infant, Newborn, Gestational age, respiratory system, medicine.disease, Flow Cytometry, Intercellular Adhesion Molecule-1, eye diseases, respiratory tract diseases, CD4 Lymphocyte Count, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Immunology, Lymphocyte activation, Female, sense organs, medicine.symptom, business, Biomarkers, Infant, Premature, Developmental Biology
Abstract

Background: Preterm infants with respiratory distress syndrome (RDS) present with systemic inflammation. The role of lymphocytes in RDS is less studied. Activation of lymphocytes could mediate chronic inflammation and development of bronchopulmonary dysplasia (BPD). Objective: To evaluate whether T cells are activated in preterm infants with RDS and whether T cell activation is associated with the development of BPD. Methods: Thirty-four infants with RDS [mean gestational age 27.1 (SD 2.0) weeks, birth weight 900 (216) g] were compared with 21 infants without RDS [32.6 (1.4) weeks, 1,697 (406) g]. From blood samples taken on postnatal days 1, 3, and 7, CD4 and CD8 cell counts and their expressions of co-stimulatory molecule CD54 and adhesion molecule CD62L were determined by flow cytometry. In activated cells, expression of CD54 is increased and CD62L is decreased. Results:As compared with infants without RDS, infants with RDS had less CD4 and CD8 cells on day 3 (both p = 0.02). On day 1 and day 3, RDS was associated with increased CD54 expression on CD4 cells (p = 0.001; p = 0.03) and decreased CD62L expression on CD8 cells (both p = 0.02). Infants with RDS who developed BPD (n = 18) had higher CD54 expression on CD4 cells on day 3 (p = 0.01) and on CD8 cells on day 1 and day 3 (p = 0.01; p = 0.04) as compared with infants without BPD (n = 16). Conclusions: In preterm infants, RDS is associated with a lower T cell count and a higher proportion of activated cells. Increased proportion of activated T cells predicts the development of BPD. Systemic T cell activation could mediate inflammation and development of BPD.

Published
2008

3. Subejct Index Vol. 96, 2009

Author

Janet Stone, Sture Andersson, Yasushi Ohki, Marianne Thoresen, Pattie Bondurant, Masayuki Watanabe, Eero Kajantie, Maureen Rider, Yukihiro Yoshizawa, Irmeli Nupponen, Christine A. Gleason, Mark H. Oliver, Ronald J. McPherson, Thuy N. Vien, Sarah L. Hays, Tamina White, Mauricio Odio, Sandra E. Juul, Carl A Kuschel, Diane Goltz, Aulikki Lano, Sanna Siitonen, Ulrike Herberg, Katinka P. Bach, Teresa Flower, Johannes Breuer, Frank H. Bloomfield, Linda Sluder, Kenichi Tokuyama, Beth Mason, Louise Smith, Ulrich Gembruch, Mathias Karlsson, Outi Vaarala, Saulius Satas, Marty O. Visscher, Shelly Sargent, Akihiro Morikawa, Teresa Taylor, Riikka Turunen, Yukiko Takahashi, Charles Chavkin, Hiroo Mayuzumi, Michael Obladen, Amy Huebner, Heikki Repo, Helen Porter, and Henning Weiss

Subjects
Pediatrics, Perinatology and Child Health, Developmental Biology
Published
2009

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