1. Endothelial dysfunction in children with chronic kidney disease
- Author
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Juan Antonio García-Bello, Rita A. Gómez-Díaz, Alicia Contreras-Rodríguez, Lorena Sánchez-Barbosa, Rafael Mondragón-González, Juan Manuel Gallardo-Montoya, and Niels H. Wacher
- Subjects
Disfunción endotelial ,Dilatación mediada por flujo ,Enfermedad cardiovascular ,Enfermedad renal crónica ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background and Objective: Cardiovascular disease (CVD) is the main cause of death in children with chronic kidney disease (CKD). Inflammation and endothelial dysfunction (ED) are found in the majority of these patients and are factors associated to CVD. Flow mediated dilatation (FMD) is a surrogate marker validated for evaluating ED. Our objective was to identify risk factors associated to ED in children with CKD. Materials and Methods: Children 2–16 years of age were studied. Clinical information and biochemical variables were gathered, including intact parathyroid hormone (iPTH), interleukins 6 and 1b, high sensitivity C reactive protein (hsCRP), reduced glutathione, nitric oxide, malondialdehyde and homocysteine. FMD was measured, and considered altered if
- Published
- 2021
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