1. [Fatal liver cell necrosis following administration of glafenine].
- Author
-
Koek GH, Stricker BH, Veldhuizen RW, and de Graaf P
- Subjects
- Aged, Arthritis, Rheumatoid drug therapy, Chemical and Drug Induced Liver Injury pathology, Glafenine therapeutic use, Hepatic Encephalopathy chemically induced, Humans, Male, Necrosis chemically induced, Chemical and Drug Induced Liver Injury etiology, Glafenine adverse effects, Liver pathology
- Abstract
The case is described of a patient with fulminant hepatic failure attributed to intake of glafenine 400 mg daily for 15 days. The first symptoms appeared two weeks after discontinuation of glafenine. Other causes of hepatic necrosis could be excluded. Approximately five weeks after the onset of symptoms the patient died of hepatic failure. At autopsy massive hepatic necrosis and massive pancreatic necrosis were demonstrated.
- Published
- 1991