1. [Carcinoma of the colon with bladder invasion; what is the role of preoperative chemotherapy?]
- Author
-
Drager LD, Verstegen MG, Sedelaar JPM, Bremers AJA, and de Wilt JHW
- Subjects
- Aged, Carcinoma pathology, Carcinoma surgery, Chemotherapy, Adjuvant, Colonic Neoplasms pathology, Colonic Neoplasms surgery, Digestive System Surgical Procedures, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Preoperative Period, Treatment Outcome, Antineoplastic Agents administration & dosage, Carcinoma drug therapy, Colonic Neoplasms drug therapy, Neoadjuvant Therapy methods, Urinary Bladder pathology
- Abstract
Preoperative chemotherapy followed by surgery was applied in three patients, aged 68 years (male), 48 years (female), and 80 years (male) with locally advanced cancer of the colon with bladder invasion. Achieving a resection with free margins (R0) is essential in colon-cancer surgery, but the role of preoperative chemotherapy in colon cancer remains unknown. When a tumour is presumed to be unresectable, guidelines recommend discussing the case and possibly referring the patient to an oncological expertise centre, where each patient will be individually assessed for the most suitable preoperative treatment and surgery during a multidisciplinary tumour board meeting. All three patients showed that preoperative chemotherapy led to down-staging and reduction of the tumour size, although removal of the bladder was still necessary in one patient. All patients underwent a complete resection, which resulted in long-term disease-free and overall survival.
- Published
- 2020