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There are several similarities between tetanus and cholera toxins, including their ability to react with ganglioside. However, tetanus toxin reacts mostly with certain gangliosides containing sialidase-sensitive bonds, whereas cholera toxin reacts only with one particular ganglioside that does not contain any sialidase-sensitive bonds. The possible implications of the similarities and dissimilarities of these two toxins are touched upon. [ABSTRACT FROM AUTHOR]

The fixation of tetanus toxin and the deactivation of cholera toxin by gangliosides are toxin-specific and ganglioside-specific, and not prevented by protective colloid, whereas the inactivation of a number of toxins by gangliosides which is prevented by protective colloid is a non-specific phenomenon. [ABSTRACT FROM AUTHOR]