1. The molecular basis for calcium-dependent axon pathfinding.
- Author
-
Gomez, Timothy M. and Zheng, James Q.
- Subjects
- *
NEURAL transmission , *NEURAL circuitry , *NEUROPHYSIOLOGY , *CALCIUM , *AXONS , *NEURONS , *MOLECULAR neurobiology , *CALCIUM metabolism , *NEURAL physiology , *ANIMAL experimentation , *BIOLOGICAL models , *CELLULAR signal transduction , *COMPARATIVE studies , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *EVALUATION research - Abstract
Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF