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Your search keyword '"Staszewski, Ori"' showing total 7 results
Start Over Author "Staszewski, Ori" Journal nature neuroscience
7 results on '"Staszewski, Ori"'

3. Microglia contribute to the propagation of Aβ into unaffected brain tissue

Author

d’Errico, Paolo, primary, Ziegler-Waldkirch, Stephanie, additional, Aires, Vanessa, additional, Hoffmann, Philippe, additional, Mezö, Charlotte, additional, Erny, Daniel, additional, Monasor, Laura Sebastian, additional, Liebscher, Sabine, additional, Ravi, Vidhya M., additional, Joseph, Kevin, additional, Schnell, Oliver, additional, Kierdorf, Katrin, additional, Staszewski, Ori, additional, Tahirovic, Sabina, additional, Prinz, Marco, additional, and Meyer-Luehmann, Melanie, additional

Published
2021
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5. Host microbiota constantly control maturation and function of microglia in the CNS

Author

Erny, Daniel, primary, Hrabě de Angelis, Anna Lena, additional, Jaitin, Diego, additional, Wieghofer, Peter, additional, Staszewski, Ori, additional, David, Eyal, additional, Keren-Shaul, Hadas, additional, Mahlakoiv, Tanel, additional, Jakobshagen, Kristin, additional, Buch, Thorsten, additional, Schwierzeck, Vera, additional, Utermöhlen, Olaf, additional, Chun, Eunyoung, additional, Garrett, Wendy S, additional, McCoy, Kathy D, additional, Diefenbach, Andreas, additional, Staeheli, Peter, additional, Stecher, Bärbel, additional, Amit, Ido, additional, and Prinz, Marco, additional

Published
2015
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6. A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Author

Tay, Tuan Leng, Mai, Dominic, Dautzenberg, Jana, Fernández-Klett, Francisco, Lin, Gen, Sagar, Datta, Moumita, Drougard, Anne, Stempfl, Thomas, Ardura-Fabregat, Alberto, Staszewski, Ori, Margineanu, Anca, Sporbert, Anje, Steinmetz, Lars M, Pospisilik, J Andrew, Jung, Steffen, Priller, Josef, Grün, Dominic, Ronneberger, Olaf, and Prinz, Marco

Abstract

Microglia constitute a highly specialized network of tissue-resident immune cells that is important for the control of tissue homeostasis and the resolution of diseases of the CNS. Little is known about how their spatial distribution is established and maintained in vivo. Here we establish a new multicolor fluorescence fate mapping system to monitor microglial dynamics during steady state and disease. Our findings suggest that microglia establish a dense network with regional differences, and the high regional turnover rates found challenge the universal concept of microglial longevity. Microglial self-renewal under steady state conditions constitutes a stochastic process. During pathology this randomness shifts to selected clonal microglial expansion. In the resolution phase, excess disease-associated microglia are removed by a dual mechanism of cell egress and apoptosis to re-establish the stable microglial network. This study unravels the dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS.

Published
2017
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7. Microglia contribute to the propagation of Aβ into unaffected brain tissue.

Author

d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, and Meyer-Luehmann M

Subjects
Brain metabolism, Humans, Neurons metabolism, Plaque, Amyloid pathology, Amyloid beta-Peptides metabolism, Microglia metabolism
Abstract

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation., (© 2021. The Author(s).)

Published
2022
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