1. Topographical representation of odor hedonics in the olfactory bulb
- Author
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Nathalie Mandairon, Anne Didier, Marc Thevenet, Nicola Kuczewski, Joëlle Sacquet, Maellie Midroit, Marion Richard, Jeremy Forest, Florence Kermen, Claire Benetollo, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,0301 basic medicine ,Olfactory perception ,Olfactory system ,Olfactory Perception/physiology ,Nerve net ,Odorants/analysis ,Optogenetics ,Biology ,Inbred C57BL ,Mice ,03 medical and health sciences ,Smell/physiology ,0302 clinical medicine ,Animal/physiology ,medicine ,Animals ,Nerve Net/physiology ,10. No inequality ,ComputingMilieux_MISCELLANEOUS ,Behavior ,Communication ,Behavior, Animal ,business.industry ,Olfactory Bulb/physiology ,[SCCO.NEUR]Cognitive science/Neuroscience ,General Neuroscience ,Representation (systemics) ,Olfactory Perception ,Olfactory Bulb ,ddc:616.8 ,Olfactory bulb ,Mice, Inbred C57BL ,Smell ,030104 developmental biology ,medicine.anatomical_structure ,Odor ,Odorants ,Nerve Net ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.
- Published
- 2016