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Your search keyword '"Moutkine I"' showing total 2 results
Start Over Author "Moutkine I" Journal nature neuroscience
2 results on '"Moutkine I"'

1. Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Author

Valentinova K, Tchenio A, Trusel M, Clerke JA, Lalive AL, Tzanoulinou S, Matera A, Moutkine I, Maroteaux L, Paolicelli RC, Volterra A, Bellone C, and Mameli M

Subjects
Adaptation, Psychological, Animals, Female, Male, Mice, Mice, Inbred C57BL, Microglia physiology, Naloxone toxicity, Neuronal Plasticity, Random Allocation, Receptors, Glutamate analysis, Receptors, N-Methyl-D-Aspartate analysis, Receptors, Tumor Necrosis Factor, Type I genetics, Receptors, Tumor Necrosis Factor, Type I physiology, Substance Withdrawal Syndrome psychology, Tumor Necrosis Factor-alpha physiology, Cytokines physiology, Habenula physiology, Morphine adverse effects, Social Behavior, Substance Withdrawal Syndrome physiopathology, Synaptic Transmission physiology
Abstract

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

Published
2019
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2. Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.

Author

Meye FJ, Valentinova K, Lecca S, Marion-Poll L, Maroteaux MJ, Musardo S, Moutkine I, Gardoni F, Huganir RL, Georges F, and Mameli M

Subjects
Animals, Conditioning, Operant drug effects, Conditioning, Operant physiology, Electric Stimulation, Excitatory Postsynaptic Potentials drug effects, Excitatory Postsynaptic Potentials physiology, Green Fluorescent Proteins genetics, Green Fluorescent Proteins metabolism, Habenula cytology, Habenula metabolism, Hindlimb Suspension, In Vitro Techniques, Luminescent Proteins genetics, Luminescent Proteins metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity drug effects, Mutation genetics, Patch-Clamp Techniques, Receptors, AMPA genetics, Swimming psychology, Red Fluorescent Protein, Cocaine pharmacology, Dopamine Uptake Inhibitors pharmacology, Habenula drug effects, Protein Transport drug effects, Receptors, AMPA metabolism
Abstract

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Published
2015
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