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Your search keyword '"McCabe, Cristin"' showing total 7 results
Start Over Author "McCabe, Cristin" Journal nature neuroscience
7 results on '"McCabe, Cristin"'

3. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Author

De Jager, Philip L, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Schalkwyk, Leonard C, Yu, Lei, Eaton, Matthew L, Keenan, Brendan T, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Chai, High S, Younkin, Curtis, Younkin, Steven G, Zou, Fanggeng, Szyf, Moshe, Epstein, Charles B, Schneider, Julie A, Bernstein, Bradley E, Meissner, Alex, Ertekin-Taner, Nilufer, Chibnik, Lori B, Kellis, Manolis, Mill, Jonathan, and Bennett, David A

Subjects
Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Alzheimer's Disease, Human Genome, Genetics, Dementia, Neurodegenerative, Acquired Cognitive Impairment, Aging, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Alzheimer Disease, Amyloidosis, Ankyrins, Brain, Carrier Proteins, CpG Islands, DNA Methylation, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Nuclear Proteins, Protein Interaction Maps, Tumor Suppressor Proteins, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.

Published
2014

4. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

Author

Klein, Hans-Ulrich, McCabe, Cristin, Gjoneska, Elizabeta, Sullivan, Sarah E., Kaskow, Belinda J., Tang, Anna, Smith, Robert V., Xu, Jishu, Pfenning, Andreas R., Bernstein, Bradley E., Meissner, Alexander, Schneider, Julie A., Mostafavi, Sara, Tsai, Li-Huei, Young-Pearse, Tracy L., Bennett, David A., and De Jager, Philip L.

Published
2019
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5. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Author

Mostafavi, Sara, Gaiteri, Chris, Sullivan, Sarah E., White, Charles C., Tasaki, Shinya, Xu, Jishu, Taga, Mariko, Klein, Hans-Ulrich, Patrick, Ellis, Komashko, Vitalina, McCabe, Cristin, Smith, Robert, Bradshaw, Elizabeth M., Root, David E., Regev, Aviv, Yu, Lei, Chibnik, Lori B., Schneider, Julie A., Young-Pearse, Tracy L., Bennett, David A., and De Jager, Philip L.

Published
2018
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7. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

Author

Klein, Hans-Ulrich, primary, McCabe, Cristin, additional, Gjoneska, Elizabeta, additional, Sullivan, Sarah E., additional, Kaskow, Belinda J., additional, Tang, Anna, additional, Smith, Robert V., additional, Xu, Jishu, additional, Pfenning, Andreas R., additional, Bernstein, Bradley E., additional, Meissner, Alexander, additional, Schneider, Julie A., additional, Mostafavi, Sara, additional, Tsai, Li-Huei, additional, Young-Pearse, Tracy L., additional, Bennett, David A., additional, and De Jager, Philip L., additional

Published
2018
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