1. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
- Author
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Sorge, Robert E., Trang, Tuan, Dorfman, Ruslan, Smith, Shad B., Beggs, Simon, Ritchie, Jennifer, Austin, Jean-Sebastien, Zaykin, Dmitri V., Meulen, Heather Vander, Costigan, Michael, Herbert, Teri A., Yarkoni-Abitbul, Merav, Tichauer, David, Livneh, Jessica, Gershon, Edith, Zheng, Ming, Tan, Keith, John, Sally L., Slade, Gary D., Jordan, Joanne, Woolf, Clifford J., Peltz, Gary, Maixner, William, Diatchenko, Luda, Seltzer, Ze'ev, Salter, Michael W., and Mogil, Jeffrey S.
- Subjects
Care and treatment ,Physiological aspects ,Development and progression ,Genetic aspects ,Research ,Analgesics -- Genetic aspects -- Research ,Cell receptors -- Physiological aspects -- Genetic aspects -- Research ,Chronic pain -- Development and progression -- Genetic aspects -- Care and treatment -- Research - Abstract
Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an understanding of the [...]
- Published
- 2012
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