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Start Over Author "Sharp, Alan H." Journal nature medicine
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1. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

Author

Sawa, Akira, Wiegand, Gordon W., Cooper, Jillian, Margolis, Russell L., Sharp, Alan H., Lawler, Joseph F., Jr., Greenamyre, J. Timothy, Snyder, Solomon H., and Ross, Christopher A.

Subjects
Huntington's chorea -- Genetic aspects, Cell death -- Causes of
Abstract

Lymphoblasts from patients with Huntington disease exhibit increased mitochondrial depolarization and cell death when subjected to stress. This illustrates that the gene defect that causes the disease affects other organs besides the brain.

Published
1999

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