1. Treg cells: patrolling a dangerous neighborhood
- Author
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Daniel J. Campbell and Meghan A. Koch
- Subjects
medicine.anatomical_structure ,Immunology ,medicine ,FOXP3 ,Germinal center ,Somatic hypermutation ,General Medicine ,Biology ,medicine.disease_cause ,Treg cell ,General Biochemistry, Genetics and Molecular Biology ,B cell ,Autoimmunity - Abstract
How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo functional specialization to limit the magnitude of the germinal center response, and they may contribute to our understanding of how germinal center–mediated autoimmunity is prevented (pages 975–982 and 983–988).
- Published
- 2011
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