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Your search keyword '"Leung, Gabriel M"' showing total 17 results
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17 results on '"Leung, Gabriel M"'

1. An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution

Author

Subissi, Lorenzo, Otieno, James Richard, Worp, Nathalie, Attar Cohen, Homa, Oude Munnink, Bas B., Abu-Raddad, Laith J., Alm, Erik, Barakat, Amal, Barclay, Wendy S., Bhiman, Jinal N., Caly, Leon, Chand, Meera, Chen, Mark, Cullinane, Ann, de Oliveira, Tulio, Drosten, Christian, Druce, Julian, Effler, Paul, El Masry, Ihab, Faye, Adama, Ghedin, Elodie, Grant, Rebecca, Haagmans, Bart L., Happi, Christian, Herring, Belinda L., Hodcroft, Emma B., Ikejezie, Juniorcaius, Katawera, Victoria, Kassamali, Zyleen Alnashir, Leo, Yee-Sin, Leung, Gabriel M., Kondor, Rebecca J., Marklewitz, Marco, Mendez-Rico, Jairo, Melhem, Nada M., Munster, Vincent, Nahapetyan, Karen, Naindoo, Dhamari, Oh, Djin-Ye, Peacock, Thomas P., Peiris, Malik, Peng, Zhibin, Poon, Leo L. M., Rambaut, Andrew, Saha, Senjuti, Shen, Yinzhong, Siqueira, Marilda M., Volz, Erik, Tessema, Sofonias K., Thiel, Volker, Triki, Henda, van der Werf, Sylvie, von Eije, Karin, Cunningham, Jane, Koopmans, Marion P. G., von Gottberg, Anne, Agrawal, Anurag, and Van Kerkhove, Maria D.

Published
2024
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3. Author Correction: Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population

Author

Lau, Jonathan J., Cheng, Samuel M. S., Leung, Kathy, Lee, Cheuk Kwong, Hachim, Asmaa, Tsang, Leo C. H., Yam, Kenny W. H., Chaothai, Sara, Kwan, Kelvin K. H., Chai, Zacary Y. H., Lo, Tiffany H. K., Mori, Masashi, Wu, Chao, Valkenburg, Sophie A., Amarasinghe, Gaya K., Lau, Eric H. Y., Hui, David S. C., Leung, Gabriel M., Peiris, Malik, and Wu, Joseph T.

Published
2024
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5. Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population

Author

Lau, Jonathan J., Cheng, Samuel M. S., Leung, Kathy, Lee, Cheuk Kwong, Hachim, Asmaa, Tsang, Leo C. H., Yam, Kenny W. H., Chaothai, Sara, Kwan, Kelvin K. H., Chai, Zacary Y. H., Lo, Tiffany H. K., Mori, Masashi, Wu, Chao, Valkenburg, Sophie A., Amarasinghe, Gaya K., Lau, Eric H. Y., Hui, David S. C., Leung, Gabriel M., Peiris, Malik, and Wu, Joseph T.

Published
2023
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6. An early warning system for emerging SARS-CoV-2 variants

Author

Subissi, Lorenzo, von Gottberg, Anne, Thukral, Lipi, Worp, Nathalie, Oude Munnink, Bas B., Rathore, Surabhi, Abu-Raddad, Laith J., Aguilera, Ximena, Alm, Erik, Archer, Brett N., Attar Cohen, Homa, Barakat, Amal, Barclay, Wendy S., Bhiman, Jinal N., Caly, Leon, Chand, Meera, Chen, Mark, Cullinane, Ann, de Oliveira, Tulio, Drosten, Christian, Druce, Julian, Effler, Paul, El Masry, Ihab, Faye, Adama, Gaseitsiwe, Simani, Ghedin, Elodie, Grant, Rebecca, Haagmans, Bart L., Herring, Belinda L., Iyer, Shilpa S., Kassamali, Zyleen, Kakkar, Manish, Kondor, Rebecca J., Leite, Juliana A., Leo, Yee-Sin, Leung, Gabriel M., Marklewitz, Marco, Moyo, Sikhulile, Mendez-Rico, Jairo, Melhem, Nada M., Munster, Vincent, Nahapetyan, Karen, Oh, Djin-Ye, Pavlin, Boris I., Peacock, Thomas P., Peiris, Malik, Peng, Zhibin, Poon, Leo L. M., Rambaut, Andrew, Sacks, Jilian, Shen, Yinzhong, Siqueira, Marilda M., Tessema, Sofonias K., Volz, Erik M., Thiel, Volker, van der Werf, Sylvie, Briand, Sylvie, Perkins, Mark D., Van Kerkhove, Maria D., Koopmans, Marion P. G., and Agrawal, Anurag

Published
2022
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7. Nowcasting epidemics of novel pathogens: lessons from COVID-19

Author

Wu, Joseph T., Leung, Kathy, Lam, Tommy T. Y., Ni, Michael Y., Wong, Carlos K. H., Peiris, J. S. Malik, and Leung, Gabriel M.

Subjects
Epidemics -- Research -- Control -- China, Medical research, Medicine, Experimental, Epidemiologic methods -- Analysis, Biological sciences, Health
Abstract

Epidemic nowcasting broadly refers to assessing the current state by understanding key pathogenic, epidemiologic, clinical and socio-behavioral characteristics of an ongoing outbreak. Its primary objective is to provide situational awareness and inform decisions on control responses. In the event of large-scale sustained emergencies, such as the COVID-19 pandemic, scientists need to constantly update their aims and analytics with respect to the rapidly evolving emergence of new questions, data and findings in order to synthesize real-time evidence for policy decisions. In this Perspective, we share our views on the functional aims, rationale, data requirements and challenges of nowcasting at different stages of an epidemic, drawing on the ongoing COVID-19 experience. We highlight how recent advances in the computational and laboratory sciences could be harnessed to complement traditional approaches to enhance the scope, timeliness, reliability and utility of epidemic nowcasting. Recent advances in computational and laboratory sciences are helping researchers to address large-scale sustained emergencies, such as the COVID-19 pandemic, and constantly adapt to the emergence of new questions, data and findings in order to synthesize real-time evidence that will inform policy decisions., Author(s): Joseph T. Wu [sup.1] [sup.2] , Kathy Leung [sup.1] [sup.2] , Tommy T. Y. Lam [sup.1] [sup.2] [sup.3] [sup.4] , Michael Y. Ni [sup.1] [sup.5] [sup.6] , Carlos K. [...]

Published
2021
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8. Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong

Author

Adam, Dillon C., Wu, Peng, Wong, Jessica Y., Lau, Eric H. Y., Tsang, Tim K., Cauchemez, Simon, and Leung, Gabriel M.

Subjects
Disease transmission -- History -- Distribution, Company distribution practices, Biological sciences, Health
Abstract

Superspreading events (SSEs) have characterized previous epidemics of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infections.sup.1-6. For SARS-CoV-2, the degree to which SSEs are involved in transmission remains unclear, but there is growing evidence that SSEs might be a typical feature of COVID-19.sup.7,8. Using contact tracing data from 1,038 SARS-CoV-2 cases confirmed between 23 January and 28 April 2020 in Hong Kong, we identified and characterized all local clusters of infection. We identified 4-7 SSEs across 51 clusters (n = 309 cases) and estimated that 19% (95% confidence interval, 15-24%) of cases seeded 80% of all local transmission. Transmission in social settings was associated with more secondary cases than households when controlling for age (P = 0.002). Decreasing the delay between symptom onset and case confirmation did not result in fewer secondary cases (P = 0.98), although the odds that an individual being quarantined as a contact interrupted transmission was 14.4 (95% CI, 1.9-107.2). Public health authorities should focus on rapidly tracing and quarantining contacts, along with implementing restrictions targeting social settings to reduce the risk of SSEs and suppress SARS-CoV-2 transmission. Cases linked to superspreading events are estimated to account for 80% of all local transmission of SARS-CoV-2 in Hong Kong in a study with implications for public health policies., Author(s): Dillon C. Adam [sup.1] [sup.2] , Peng Wu [sup.1] , Jessica Y. Wong [sup.1] , Eric H. Y. Lau [sup.1] , Tim K. Tsang [sup.1] , Simon Cauchemez [sup.3] [...]

Published
2020
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9. Respiratory virus shedding in exhaled breath and efficacy of face masks

Author

Leung, Nancy H.L., Chu, Daniel K.W., Shiu, Eunice Y.C., Chan, Kwok-Hung, McDevitt, James J., Hau, Benien J.P., Yen, Hui-Ling, Li, Yuguo, Ip, Dennis K.M., Peiris, J.S. Malik, Seto, Wing-Hong, Leung, Gabriel M., Milton, Donald K., and Cowling, Benjamin J.

Subjects
Testing, Prevention, Evaluation, Physiological aspects, Influenza viruses -- Testing -- Physiological aspects, Disease transmission -- Prevention, Coronaviruses -- Testing -- Physiological aspects, Respiratory tract diseases -- Prevention, Rhinoviruses -- Testing -- Physiological aspects -- Prevention, Face masks (Respiratory protective equipment) -- Evaluation
Abstract

Author(s): Nancy H. L. Leung [sup.1] , Daniel K. W. Chu [sup.1] , Eunice Y. C. Shiu [sup.1] , Kwok-Hung Chan [sup.2] , James J. McDevitt [sup.3] , Benien J. [...], We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols, with a trend toward reduced detection of coronavirus RNA in respiratory droplets. Our results indicate that surgical face masks could prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals. A study of 246 individuals with seasonal respiratory virus infections randomized to wear or not wear a surgical face mask showed that masks can significantly reduce detection of coronavirus and influenza virus in exhaled breath and may help interrupt virus transmission.

Published
2020
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10. Temporal dynamics in viral shedding and transmissibility of COVID-19

Author

He, Xi, Lau, Eric H. Y., Wu, Peng, Deng, Xilong, Wang, Jian, Hao, Xinxin, Lau, Yiu Chung, Wong, Jessica Y., Guan, Yujuan, Tan, Xinghua, Mo, Xiaoneng, Chen, Yanqing, Liao, Baolin, Chen, Weilie, Hu, Fengyu, Zhang, Qing, Zhong, Mingqiu, Wu, Yanrong, Zhao, Lingzhai, Zhang, Fuchun, Cowling, Benjamin J., Li, Fang, and Leung, Gabriel M.

Published
2020
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13. Author Correction: Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population

Author

Lau, Jonathan J., primary, Cheng, Samuel M. S., additional, Leung, Kathy, additional, Lee, Cheuk Kwong, additional, Hachim, Asmaa, additional, Tsang, Leo C. H., additional, Yam, Kenny W. H., additional, Chaothai, Sara, additional, Kwan, Kelvin K. H., additional, Chai, Zacary Y. H., additional, Lo, Tiffany H. K., additional, Mori, Masashi, additional, Wu, Chao, additional, Valkenburg, Sophie A., additional, Amarasinghe, Gaya K., additional, Lau, Eric H. Y., additional, Hui, David S. C., additional, Leung, Gabriel M., additional, Peiris, Malik, additional, and Wu, Joseph T., additional

Published
2023
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