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Author(s): Qing-Sheng Mi (corresponding author) [1, 2, 3]; Zhong-Bin Deng [1]; Sunil K Joshi [1, 2]; Zai-Zhao Wang [1]; Li Zhou [1, 2]; Sarah Eckenrode [1]; Ratanmani Joshi [1, 2]; [...]

Author(s): Qing-Sheng Mi; Zhong-Bin Deng; Sunil K Joshi; Zai-Zhao Wang; Li Zhou; Sarah Eckenrode; Ratanmani Joshi; Dalam Ly; Bing Yi; Terry L Delovitch; Jin-Xiong She Nature Medicine 12, 624-626 (2006) [...]

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1. [ABSTRACT FROM AUTHOR]