1. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
- Author
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Barber DF, Bartolomé A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C, Camps M, Rückle T, Schwarz MK, Rodríguez S, Martinez-A C, Balomenos D, Rommel C, and Carrera AC
- Subjects
- Animals, Disease Models, Animal, Female, Male, Mice, Mice, Mutant Strains, Enzyme Inhibitors therapeutic use, Lupus Erythematosus, Systemic drug therapy, Lupus Nephritis prevention & control, Phosphoinositide-3 Kinase Inhibitors, Quinoxalines pharmacology, Thiazolidinediones pharmacology
- Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell-mediated B-cell activation, which results in glomerulonephritis and renal failure. Disease is treated with immunosuppressants and cytostatic agents that have numerous side effects. Here we examine the use of inhibitors of phosphoinositide 3-kinase (PI3K) gamma, a lipid kinase that regulates inflammation, in the MRL-lpr mouse model of SLE. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that P13Kgamma may be a useful target in the treatment of chronic inflammation.
- Published
- 2005
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