1. Vascular anastomosis using controlled phase transitions in poloxamer gels
- Author
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Edward I. Chang, Jason P. Glotzbach, Samyra El-ftesi, Cynthia D. Hamou, Jayakumar Rajadas, C. Travis Rappleye, Gerald G. Fuller, Geoffrey C. Gurtner, Kristin Maria Sommer, Michael G. Galvez, Michael T. Longaker, and Oscar J. Abilez
- Subjects
Male ,medicine.medical_specialty ,Intimal hyperplasia ,Lumen (anatomy) ,Poloxamer ,Anastomosis ,General Biochemistry, Genetics and Molecular Biology ,Phase Transition ,Fibrosis ,medicine.artery ,Elastic Modulus ,Vascular anastomosis ,medicine ,Animals ,Aorta ,business.industry ,Anastomosis, Surgical ,General Medicine ,medicine.disease ,Immunohistochemistry ,Surgery ,Rats ,Microvessels ,Microscopy, Electron, Scanning ,Foreign body ,business ,Rheology - Abstract
Vascular anastomosis is the cornerstone of vascular, cardiovascular and transplant surgery. Most anastomoses are performed with sutures, which are technically challenging and can lead to failure from intimal hyperplasia and foreign body reaction. Numerous alternatives to sutures have been proposed, but none has proven superior, particularly in small or atherosclerotic vessels. We have developed a new method of sutureless and atraumatic vascular anastomosis that uses US Food and Drug Administration (FDA)-approved thermoreversible tri-block polymers to temporarily maintain an open lumen for precise approximation with commercially available glues. We performed end-to-end anastomoses five times more rapidly than we performed hand-sewn controls, and vessels that were too small (
- Published
- 2010