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Start Over Author "North, Kathryn N" Search Limiters Peer Reviewed Topic duchenne muscular dystrophy Journal nature medicine

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1 results on '"North, Kathryn N"'

1. Activating internal ribosome entry to treat Duchenne muscular dystrophy.

Author

Lamandé, Shireen R and North, Kathryn N

Subjects
*SYNTROPHINS, *EXONS (Genetics), *DUCHENNE muscular dystrophy, *DYSTROPHIN
Abstract

The article discusses the study by Wein, N. and colleagues to demonstrate that initiation of Duchenne muscular dystrophy (DMD) exon 6 translation is driven by an internal ribosome entry site (IRES) in exon 5 nucleic acid sequence and this allows translation of truncated form of dystrophin protein. It states that mass spectrometry on muscle biopsy tissue of an asymptomatic individual was carried out and a form of dystrophin was detected and therapeutic use of IRES modulation was established.

Published
2014
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