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2. Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

3. Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial

5. Intracerebroventricular anaerobic dopamine in Parkinson’s disease with l-dopa-related complications: a phase 1/2 randomized-controlled trial

6. Multi-omics-based mapping of decidualization resistance in patients with a history of severe preeclampsia

9. Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB–D melanoma: a phase 1/2 trial

10. Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

12. Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial

13. Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial

14. Spatial multiomic landscape of the human placenta at molecular resolution

15. Deep learning versus manual morphology-based embryo selection in IVF: a randomized, double-blind noninferiority trial

16. Role of anticoagulation therapy in modifying stroke risk associated with new-onset atrial fibrillation after non-cardiac surgery

18. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma

20. An open-source framework for end-to-end analysis of electronic health record data

21. Increased frequency of repeat expansion mutations across different populations

22. Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition

23. Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial

24. SARS-CoV-2 correlates of protection from infection against variants of concern

26. Adaptive selection at G6PD and disparities in diabetes complications

27. DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism

28. Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

31. The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial

33. Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes

34. Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial

35. Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

36. High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

37. Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results

39. Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial

41. A multi-ancestry genetic study of pain intensity in 598,339 veterans

47. Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities

49. Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial

50. Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria