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Your search keyword '"Wieghofer, Peter"' showing total 4 results
Start Over Author "Wieghofer, Peter" Journal nature immunology
4 results on '"Wieghofer, Peter"'

1. Origin, fate and dynamics of macrophages at central nervous system interfaces

Author

Goldmann, Tobias, Wieghofer, Peter, Jordão, Marta Joana Costa, Prutek, Fabiola, Hagemeyer, Nora, Frenzel, Kathrin, Amann, Lukas, Staszewski, Ori, Kierdorf, Katrin, Krueger, Martin, Locatelli, Giuseppe, Hochgerner, Hannah, Zeiser, Robert, Epelman, Slava, Geissmann, Frederic, Priller, Josef, Rossi, Fabio M V, Bechmann, Ingo, Kerschensteiner, Martin, Linnarsson, Sten, Jung, Steffen, and Prinz, Marco

Published
2016
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2. Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

Author

Ensan, Sherine, primary, Li, Angela, additional, Besla, Rickvinder, additional, Degousee, Norbert, additional, Cosme, Jake, additional, Roufaiel, Mark, additional, Shikatani, Eric A, additional, El-Maklizi, Mahmoud, additional, Williams, Jesse W, additional, Robins, Lauren, additional, Li, Cedric, additional, Lewis, Bonnie, additional, Yun, Tae Jin, additional, Lee, Jun Seong, additional, Wieghofer, Peter, additional, Khattar, Ramzi, additional, Farrokhi, Kaveh, additional, Byrne, John, additional, Ouzounian, Maral, additional, Zavitz, Caleb C J, additional, Levy, Gary A, additional, Bauer, Carla M T, additional, Libby, Peter, additional, Husain, Mansoor, additional, Swirski, Filip K, additional, Cheong, Cheolho, additional, Prinz, Marco, additional, Hilgendorf, Ingo, additional, Randolph, Gwendalyn J, additional, Epelman, Slava, additional, Gramolini, Anthony O, additional, Cybulsky, Myron I, additional, Rubin, Barry B, additional, and Robbins, Clinton S, additional

Published
2015
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3. Self-renewing resident arterial macrophages arise from embryonic CX3CR1+precursors and circulating monocytes immediately after birth

Author

Ensan, Sherine, Li, Angela, Besla, Rickvinder, Degousee, Norbert, Cosme, Jake, Roufaiel, Mark, Shikatani, Eric A, El-Maklizi, Mahmoud, Williams, Jesse W, Robins, Lauren, Li, Cedric, Lewis, Bonnie, Yun, Tae Jin, Lee, Jun Seong, Wieghofer, Peter, Khattar, Ramzi, Farrokhi, Kaveh, Byrne, John, Ouzounian, Maral, Zavitz, Caleb C J, Levy, Gary A, Bauer, Carla M T, Libby, Peter, Husain, Mansoor, Swirski, Filip K, Cheong, Cheolho, Prinz, Marco, Hilgendorf, Ingo, Randolph, Gwendalyn J, Epelman, Slava, Gramolini, Anthony O, Cybulsky, Myron I, Rubin, Barry B, and Robbins, Clinton S

Abstract

Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1+precursors and postnatally from bone marrow–derived monocytes that colonize the tissue immediately after birth. In adulthood, proliferation (rather than monocyte recruitment) sustains arterial macrophages in the steady state and after severe depletion following sepsis. After infection, arterial macrophages return rapidly to functional homeostasis. Finally, survival of resident arterial macrophages depends on a CX3CR1-CX3CL1 axis within the vascular niche.

Published
2016
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4. Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.

Author

Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, and Robbins CS

Subjects
Animals, CX3C Chemokine Receptor 1, Cell Survival, Chemokine CX3CL1 metabolism, Cluster Analysis, Female, Gene Expression Profiling, Immunophenotyping, Macrophages immunology, Macrophages microbiology, Male, Mice, Mice, Transgenic, Phenotype, Protein Binding, Stem Cell Niche, Transcriptome, Cell Self Renewal, Embryonic Stem Cells cytology, Embryonic Stem Cells metabolism, Macrophages cytology, Macrophages metabolism, Monocytes cytology, Monocytes metabolism, Receptors, Chemokine metabolism
Abstract

Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1(+) precursors and postnatally from bone marrow-derived monocytes that colonize the tissue immediately after birth. In adulthood, proliferation (rather than monocyte recruitment) sustains arterial macrophages in the steady state and after severe depletion following sepsis. After infection, arterial macrophages return rapidly to functional homeostasis. Finally, survival of resident arterial macrophages depends on a CX3CR1-CX3CL1 axis within the vascular niche.

Published
2016
Full Text
View/download PDF

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