1. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
- Author
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Yang, Cliff Y, Best, J Adam, Knell, Jamie, Yang, Edward, Sheridan, Alison D, Jesionek, Adam K, Li, Haiyan S, Rivera, Richard R, Lind, Kristin Camfield, D'Cruz, Louise M, Watowich, Stephanie S, Murre, Cornelis, and Goldrath, Ananda W
- Subjects
TRANSCRIPTION factors ,T cells ,CYTOKINES ,CELL receptors ,GENE expression ,IMMUNOLOGIC memory - Abstract
During infection, naive CD8
+ T cells differentiate into effector cells, which are armed to eliminate pathogens, and memory cells, which are poised to protect against reinfection. The transcriptional program that regulates terminal differentiation into short-lived effector-memory versus long-lived memory cells is not clearly defined. Through the use of mice expressing reporters for the DNA-binding inhibitors Id2 and Id3, we identified Id3hi precursors of long-lived memory cells before the peak of T cell population expansion or upregulation of cell-surface receptors that indicate memory potential. Deficiency in Id2 or Id3 resulted in loss of distinct CD8+ effector and memory populations, which demonstrated unique roles for these inhibitors of E-protein transcription factors. Furthermore, cytokines altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression. [ABSTRACT FROM AUTHOR]- Published
- 2011
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