1. Antigen-specific NK cell memory in rhesus macaques
- Author
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Jamie L. Schafer, Cordelia Manickam, R. Keith Reeves, Ulrich H. von Andrian, Valerie Varner, Haiying Li, Dan H. Barouch, Marcus Altfeld, Eryn Blass, Leila Eslamizar, Stephanie Jost, and Hualin Li
- Subjects
Immunology ,Simian Acquired Immunodeficiency Syndrome ,Biology ,Article ,CD49b ,Interleukin 21 ,NK-92 ,Immunology and Allergy ,Animals ,Antigen-presenting cell ,AIDS Vaccines ,Lymphokine-activated killer cell ,Janus kinase 3 ,Dendritic Cells ,Virology ,Macaca mulatta ,3. Good health ,Killer Cells, Natural ,Liver ,Interleukin 12 ,Myeloid-derived Suppressor Cell ,HIV-1 ,Simian Immunodeficiency Virus ,Immunologic Memory ,Spleen ,Receptors, NK Cell Lectin-Like - Abstract
Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.
- Published
- 2015