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Your search keyword '"Ishii, Ken"' showing total 13 results
Start Over Author "Ishii, Ken" Journal nature immunology
13 results on '"Ishii, Ken"'

3. Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

Author

Natsuaki, Yohei, primary, Egawa, Gyohei, additional, Nakamizo, Satoshi, additional, Ono, Sachiko, additional, Hanakawa, Sho, additional, Okada, Takaharu, additional, Kusuba, Nobuhiro, additional, Otsuka, Atsushi, additional, Kitoh, Akihiko, additional, Honda, Tetsuya, additional, Nakajima, Saeko, additional, Tsuchiya, Soken, additional, Sugimoto, Yukihiko, additional, Ishii, Ken J, additional, Tsutsui, Hiroko, additional, Yagita, Hideo, additional, Iwakura, Yoichiro, additional, Kubo, Masato, additional, Ng, Lai guan, additional, Hashimoto, Takashi, additional, Fuentes, Judilyn, additional, Guttman-Yassky, Emma, additional, Miyachi, Yoshiki, additional, and Kabashima, Kenji, additional

Published
2014
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4. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Author

Uematsu, Satoshi, primary, Fujimoto, Kosuke, additional, Jang, Myoung Ho, additional, Yang, Bo-Gie, additional, Jung, Yun-Jae, additional, Nishiyama, Mika, additional, Sato, Shintaro, additional, Tsujimura, Tohru, additional, Yamamoto, Masafumi, additional, Yokota, Yoshifumi, additional, Kiyono, Hiroshi, additional, Miyasaka, Masayuki, additional, Ishii, Ken J, additional, and Akira, Shizuo, additional

Published
2008
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5. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Author

Yamamoto, Masahiro, primary, Okamoto, Toru, additional, Takeda, Kiyoshi, additional, Sato, Shintaro, additional, Sanjo, Hideki, additional, Uematsu, Satoshi, additional, Saitoh, Tatsuya, additional, Yamamoto, Naoki, additional, Sakurai, Hiroaki, additional, Ishii, Ken J, additional, Yamaoka, Shoji, additional, Kawai, Taro, additional, Matsuura, Yoshiharu, additional, Takeuchi, Osamu, additional, and Akira, Shizuo, additional

Published
2006
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6. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

Author

Uematsu, Satoshi, primary, Jang, Myoung Ho, additional, Chevrier, Nicolas, additional, Guo, Zijin, additional, Kumagai, Yutaro, additional, Yamamoto, Masahiro, additional, Kato, Hiroki, additional, Sougawa, Nagako, additional, Matsui, Hidenori, additional, Kuwata, Hirotaka, additional, Hemmi, Hiroaki, additional, Coban, Cevayir, additional, Kawai, Taro, additional, Ishii, Ken J, additional, Takeuchi, Osamu, additional, Miyasaka, Masayuki, additional, Takeda, Kiyoshi, additional, and Akira, Shizuo, additional

Published
2006
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7. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

Author

Ishii, Ken J, primary, Coban, Cevayir, additional, Kato, Hiroki, additional, Takahashi, Ken, additional, Torii, Yuichi, additional, Takeshita, Fumihiko, additional, Ludwig, Holger, additional, Sutter, Gerd, additional, Suzuki, Koichi, additional, Hemmi, Hiroaki, additional, Sato, Shintaro, additional, Yamamoto, Masahiro, additional, Uematsu, Satoshi, additional, Kawai, Taro, additional, Takeuchi, Osamu, additional, and Akira, Shizuo, additional

Published
2005
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9. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Author

Kawai, Taro, primary, Sato, Shintaro, additional, Ishii, Ken J, additional, Coban, Cevayir, additional, Hemmi, Hiroaki, additional, Yamamoto, Masahiro, additional, Terai, Kenta, additional, Matsuda, Michiyuki, additional, Inoue, Jun-ichiro, additional, Uematsu, Satoshi, additional, Takeuchi, Osamu, additional, and Akira, Shizuo, additional

Published
2004
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10. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

Author

Uematsu, Satoshi, Myoung Ho Jang, Chevrier, Nicolas, Zijin Guo, Kumagai, Yutaro, Yamamoto, Masahiro, Kato, Hiroki, Sougawa, Nagako, Matsui, Hidenori, Kuwata, Hirotaka, Hemmi, Hiroaki, Coban, Cevayir, Kawai, Taro, Ishii, Ken J., Takeuchi, Osamu, Miyasaka, Masayuki, Takeda, Kiyoshi, and Akira, Shizuo

Subjects
BACTERIAL diseases, PATHOGENIC bacteria, DENDRITIC cells, MACROPHAGES, SALMONELLA typhimurium, CYTOKINES, LYMPH nodes
Abstract

Toll-like receptors (TLRs) recognize distinct microbial components and induce innate immune responses. TLR5 is triggered by bacterial flagellin. Here we generated Tlr5−/− 1mice and assessed TLR5 function in vivo. Unlike other TLRs, TLR5 was not expressed on conventional dendritic cells or macrophages. In contrast, TLR5 was expressed mainly on intestinal CD11c+ lamina propria cells (LPCs). CD11c+ LPCs detected pathogenic bacteria and secreted proinflammatory cytokines in a TLR5-dependent way. However, CD11c+ LPCs do not express TLR4 and did not secrete proinflammatory cytokines after exposure to a commensal bacterium. Notably, transport of pathogenic Salmonella typhimurium from the intestinal tract to mesenteric lymph nodes was impaired in Tlr5−/− mice. These data suggest that CD11c+ LPCs, via TLR5, detect and are used by pathogenic bacteria in the intestinal lumen. [ABSTRACT FROM AUTHOR]

Published
2006
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11. Interferon-ainduction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

Author

Taro Kawai, Shintaro Sato, Ishii, Ken J., Coban, Cevayir, Hemmi, Hiroaki, Yamamoto, Masahiro, Terai, Kenta, Matsuda, Michiyuki, Inoue, Jun-ichiro, Uematsu, Satoshi, Takeuchi, Osamu, and Akira, Shizuo

Subjects
PATHOGENIC microorganisms, ANTIVIRAL agents, PROTEINS, INTERLEUKIN-1, INTERFERONS, UBIQUITIN
Abstract

Toll-like receptors (TLRs) are involved in the recognition of microbial pathogens. A subset of TLRs, TLR7, TLR8 and TLR9, induces antiviral responses by producing interferon-a (lFN-α). Production of lFN-α is dependent on the Toll-interleukin-1 receptor domain-containing adaptor MyD88. Here we show that MyD88 formed a complex with the transcription factor IRF7 but not with IRF3. The death domain of MyD88 interacted with an inhibitory domain of IRF7, and this interaction resulted in activation of the lFN-α-dependent promoters. Furthermore, the adaptor molecule TRAF6 also bound and activated IRF7. Ubiquitin ligase activity of TRAF6 was required for IRF7 activation. These results indicate that TLR-mediated IFN-α induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination. [ABSTRACT FROM AUTHOR]

Published
2004
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12. Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA.

Author

Ishii, Ken J., Coban, Cevayir, Kato, Hiroki, Takahashi, Ken, Torii, Yuichi, Takeshita, Fumihiko, Ludwig, Holger, Sutter, Gerd, Suzuki, Koichi, Hemmi, Hiroaki, Sato, Shintaro, Yamamoto, Masahiro, Uematsu, Satoshi, Kawai, Taro, Takeuchi, Osamu, and Akira, Shizuo

Subjects
*ANTIVIRAL agents
Abstract

A correction to the article "A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA," by Ken J. Ishii and colleagues, published online on November 13, 2005 by "Nature Immunology," is presented.

Published
2006
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13. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

Author

Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, Takeuchi O, and Akira S

Subjects
Adaptor Proteins, Signal Transducing, Animals, Humans, Interferon Regulatory Factor-7, Mice, Mice, Inbred C57BL, Myeloid Differentiation Factor 88, TNF Receptor-Associated Factor 6, Toll-Like Receptor 7, Toll-Like Receptor 8, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitin metabolism, Antigens, Differentiation physiology, DNA-Binding Proteins physiology, Interferon-alpha biosynthesis, Membrane Glycoproteins physiology, Proteins physiology, Receptors, Cell Surface physiology, Receptors, Immunologic physiology
Abstract

Toll-like receptors (TLRs) are involved in the recognition of microbial pathogens. A subset of TLRs, TLR7, TLR8 and TLR9, induces antiviral responses by producing interferon-alpha (IFN-alpha). Production of IFN-alpha is dependent on the Toll-interleukin-1 receptor domain-containing adaptor MyD88. Here we show that MyD88 formed a complex with the transcription factor IRF7 but not with IRF3. The death domain of MyD88 interacted with an inhibitory domain of IRF7, and this interaction resulted in activation of the IFN-alpha-dependent promoters. Furthermore, the adaptor molecule TRAF6 also bound and activated IRF7. Ubiquitin ligase activity of TRAF6 was required for IRF7 activation. These results indicate that TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination.

Published
2004
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