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Your search keyword '"Graham Ogg"' showing total 3 results
Start Over Author "Graham Ogg" Journal nature immunology
3 results on '"Graham Ogg"'

1. Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a

Author

Gwennaëlle C. Monnot, Marcin Wegrecki, Tan-Yun Cheng, Yi-Ling Chen, Brigitte N. Sallee, Reka Chakravarthy, Ioanna Maria Karantza, Shin Yi Tin, Alexandra E. Khaleel, Isha Monga, Laura N. Uwakwe, Alice Tillman, Bin Cheng, Soundos Youssef, Soo Weei Ng, Adam Shahine, Javier A. Garcia-Vilas, Anne-Catrin Uhlemann, Lindsey A. Bordone, Arnold Han, Christine H. Rohde, Graham Ogg, D. Branch Moody, Jamie Rossjohn, and Annemieke de Jong

Subjects
Antigens, CD1, Langerhans Cells, Staphylococcus, Immunology, Immunology and Allergy, Humans, Phosphatidylglycerols, Autoantigens, Dermatitis, Atopic, Skin
Abstract

Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a presents microbial ligands from bacteria colonizing the skin is unclear. Here we identified CD1a-dependent T cell responses to phosphatidylglycerol (PG), a ubiquitous bacterial membrane phospholipid, as well as to lysylPG, a modified PG, present in several Gram-positive bacteria and highly abundant in Staphylococcus aureus. The crystal structure of the CD1a-PG complex showed that the acyl chains were buried within the A'- and F'-pockets of CD1a, while the phosphoglycerol headgroup remained solvent exposed in the F'-portal and was available for T cell receptor contact. Using lysylPG and PG-loaded CD1a tetramers, we identified T cells in peripheral blood and in skin that respond to these lipids in a dose-dependent manner. Tetramer

Published
2021

2. An immunodominant NP

Author

Yanchun, Peng, Suet Ling, Felce, Danning, Dong, Frank, Penkava, Alexander J, Mentzer, Xuan, Yao, Guihai, Liu, Zixi, Yin, Ji-Li, Chen, Yongxu, Lu, Dannielle, Wellington, Peter A C, Wing, Delaney C C, Dominey-Foy, Chen, Jin, Wenbo, Wang, Megat Abd, Hamid, Ricardo A, Fernandes, Beibei, Wang, Anastasia, Fries, Xiaodong, Zhuang, Neil, Ashley, Timothy, Rostron, Craig, Waugh, Paul, Sopp, Philip, Hublitz, Ryan, Beveridge, Tiong Kit, Tan, Christina, Dold, Andrew J, Kwok, Charlotte, Rich-Griffin, Wanwisa, Dejnirattisa, Chang, Liu, Prathiba, Kurupati, Isar, Nassiri, Robert A, Watson, Orion, Tong, Chelsea A, Taylor, Piyush, Kumar Sharma, Bo, Sun, Fabiola, Curion, Santiago, Revale, Lucy C, Garner, Kathrin, Jansen, Ricardo C, Ferreira, Moustafa, Attar, Jeremy W, Fry, Rebecca A, Russell, Hans J, Stauss, William, James, Alain, Townsend, Ling-Pei, Ho, Paul, Klenerman, Juthathip, Mongkolsapaya, Gavin R, Screaton, Calliope, Dendrou, Stephen N, Sansom, Rachael, Bashford-Rogers, Benny, Chain, Geoffrey L, Smith, Jane A, McKeating, Benjamin P, Fairfax, Paul, Bowness, Andrew J, McMichael, Graham, Ogg, Julian C, Knight, and Tao, Dong

Subjects
Male, Immunodominant Epitopes, SARS-CoV-2, Gene Expression Profiling, Antibody Affinity, Receptors, Antigen, T-Cell, COVID-19, Vaccinia virus, Middle Aged, Nucleocapsid Proteins, Antibodies, Viral, Severity of Illness Index, HLA-B7 Antigen, Humans, Female, Amino Acid Sequence, Immunologic Memory, Aged, Cell Line, Transformed, T-Lymphocytes, Cytotoxic
Abstract

NP

Published
2021

3. Broad and strong memory CD4

Author

Yanchun, Peng, Alexander J, Mentzer, Guihai, Liu, Xuan, Yao, Zixi, Yin, Danning, Dong, Wanwisa, Dejnirattisai, Timothy, Rostron, Piyada, Supasa, Chang, Liu, César, López-Camacho, Jose, Slon-Campos, Yuguang, Zhao, David I, Stuart, Guido C, Paesen, Jonathan M, Grimes, Alfred A, Antson, Oliver W, Bayfield, Dorothy E D P, Hawkins, De-Sheng, Ker, Beibei, Wang, Lance, Turtle, Krishanthi, Subramaniam, Paul, Thomson, Ping, Zhang, Christina, Dold, Jeremy, Ratcliff, Peter, Simmonds, Thushan, de Silva, Paul, Sopp, Dannielle, Wellington, Ushani, Rajapaksa, Yi-Ling, Chen, Mariolina, Salio, Giorgio, Napolitani, Wayne, Paes, Persephone, Borrow, Benedikt M, Kessler, Jeremy W, Fry, Nikolai F, Schwabe, Malcolm G, Semple, J Kenneth, Baillie, Shona C, Moore, Peter J M, Openshaw, M Azim, Ansari, Susanna, Dunachie, Eleanor, Barnes, John, Frater, Georgina, Kerr, Philip, Goulder, Teresa, Lockett, Robert, Levin, Yonghong, Zhang, Ronghua, Jing, Ling-Pei, Ho, Richard J, Cornall, Christopher P, Conlon, Paul, Klenerman, Gavin R, Screaton, Juthathip, Mongkolsapaya, Andrew, McMichael, Julian C, Knight, and Graham, Ogg

Subjects
CD4-Positive T-Lymphocytes, COVID-19 Vaccines, Immunodominant Epitopes, SARS-CoV-2, Pneumonia, Viral, COVID-19, Epitopes, T-Lymphocyte, Viral Vaccines, CD8-Positive T-Lymphocytes, United Kingdom, Betacoronavirus, Spike Glycoprotein, Coronavirus, Humans, Coronavirus Infections, Antigens, Viral, Immunologic Memory, Pandemics
Abstract

The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4

Published
2020

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