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Your search keyword '"Ghosh, Sankar"' showing total 8 results
Start Over Author "Ghosh, Sankar" Journal nature immunology
8 results on '"Ghosh, Sankar"'

2. Regulatory T cells: recommendations to simplify the nomenclature

Author

Abbas, Abul K, Benoist, Christophe, Bluestone, Jeffrey A, Campbell, Daniel J, Ghosh, Sankar, Hori, Shohei, Jiang, Shuiping, Kuchroo, Vijay K, Mathis, Diane, Roncarolo, Maria Grazia, Rudensky, Alexander, Sakaguchi, Shimon, Shevach, Ethan M, Vignali, Dario AA, and Ziegler, Steve F

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Animals, Humans, T-Lymphocytes, Regulatory, Terminology as Topic, Biochemistry and cell biology
Published
2013

4. Phosphoinositide-dependent kinase 1 integrates T cell receptor and CD28 co-receptor signaling to effect NF-κB induction and T cell activation

Author

Park, Sung-Gyoo, Schulze-Luehrman, Jan, Hayden, Matthew S., Hashimoto, Naoko, Ogawa, Wataru, Kasuga, Masato, and Ghosh, Sankar

Subjects
animal structures, Cell Survival, T-Lymphocytes, NF-kappa B, Receptors, Antigen, T-Cell, hemic and immune systems, chemical and pharmacologic phenomena, Electrophoretic Mobility Shift Assay, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Protein Serine-Threonine Kinases, Flow Cytometry, Lymphocyte Activation, Article, 3-Phosphoinositide-Dependent Protein Kinases, CARD Signaling Adaptor Proteins, Mice, Protein Kinase C-delta, CD28 Antigens, Microscopy, Fluorescence, Animals, Immunoprecipitation, Phosphorylation, Signal Transduction
Abstract

In addition to ligation of the T cell antigen receptor (TCR), activation of the CD28 coreceptor by the costimulatory molecule B7 is required for induction of the transcription factor NF-kappaB and robust T cell activation, although the contribution of CD28 to this process remains incompletely understood. We show here that phosphoinositide-dependent kinase 1 (PDK1) is essential for integrating the TCR and CD28 signals. After we deleted PDK1 from T cells, TCR-CD28 signals were unable to induce activation of NF-kappaB or phosphorylation of protein kinase C-theta, although T cell survival and pathways dependent on the kinases p38 and Jnk or the transcription factor NFAT were unaffected. CD28 facilitated NF-kappaB activation by regulating recruitment and phosphorylation of PDK1, which are necessary for efficient binding of PDK1 to protein kinase C-theta and the adaptor CARMA1 and thus for NF-kappaB induction.

Published
2009

7. Crosstalk in NF-?B signaling pathways.

Author

Oeckinghaus, Andrea, Hayden, Matthew S, and Ghosh, Sankar

Subjects
NF-kappa B, IMMUNOREGULATION, CELLULAR signal transduction, APOPTOSIS, PHYSIOLOGICAL stress, CELL differentiation, CELLULAR control mechanisms
Abstract

NF-?B transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-?B activation, which can in turn mediate varied transcriptional programs. Consequently, NF-?B-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-?B into cell type- and context-specific responses. [ABSTRACT FROM AUTHOR]

Published
2011
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8. The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.

Author

Park SG, Schulze-Luehrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, and Ghosh S

Subjects
3-Phosphoinositide-Dependent Protein Kinases, Animals, CARD Signaling Adaptor Proteins immunology, CARD Signaling Adaptor Proteins metabolism, CD28 Antigens metabolism, Cell Survival, Electrophoretic Mobility Shift Assay, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunoprecipitation, Mice, Mice, Transgenic, Microscopy, Fluorescence, NF-kappa B metabolism, Phosphorylation, Protein Kinase C-delta immunology, Protein Kinase C-delta metabolism, Receptors, Antigen, T-Cell metabolism, Signal Transduction immunology, T-Lymphocytes metabolism, CD28 Antigens immunology, Lymphocyte Activation immunology, NF-kappa B immunology, Protein Serine-Threonine Kinases metabolism, Receptors, Antigen, T-Cell immunology, T-Lymphocytes immunology
Abstract

In addition to ligation of the T cell antigen receptor (TCR), activation of the CD28 coreceptor by the costimulatory molecule B7 is required for induction of the transcription factor NF-kappaB and robust T cell activation, although the contribution of CD28 to this process remains incompletely understood. We show here that phosphoinositide-dependent kinase 1 (PDK1) is essential for integrating the TCR and CD28 signals. After we deleted PDK1 from T cells, TCR-CD28 signals were unable to induce activation of NF-kappaB or phosphorylation of protein kinase C-theta, although T cell survival and pathways dependent on the kinases p38 and Jnk or the transcription factor NFAT were unaffected. CD28 facilitated NF-kappaB activation by regulating recruitment and phosphorylation of PDK1, which are necessary for efficient binding of PDK1 to protein kinase C-theta and the adaptor CARMA1 and thus for NF-kappaB induction.

Published
2009
Full Text
View/download PDF

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