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Your search keyword '"Ellmeier, Wilfried"' showing total 7 results
Start Over Author "Ellmeier, Wilfried" Journal nature immunology
7 results on '"Ellmeier, Wilfried"'

2. Erratum: Corrigendum: CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Author

Boucheron, Nicole, primary, Tschismarov, Roland, additional, Goeschl, Lisa, additional, A Moser, Mirjam, additional, Lagger, Sabine, additional, Sakaguchi, Shinya, additional, Winter, Mircea, additional, Lenz, Florian, additional, Vitko, Dijana, additional, Breitwieser, Florian P, additional, Müller, Lena, additional, Hassan, Hammad, additional, Bennett, Keiryn L, additional, Colinge, Jacques, additional, Schreiner, Wolfgang, additional, Egawa, Takeshi, additional, Taniuchi, Ichiro, additional, Matthias, Patrick, additional, Seiser, Christian, additional, and Ellmeier, Wilfried, additional

Published
2014
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3. CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Author

Boucheron, Nicole, primary, Tschismarov, Roland, additional, Göschl, Lisa, additional, Moser, Mirjam A, additional, Lagger, Sabine, additional, Sakaguchi, Shinya, additional, Winter, Mircea, additional, Lenz, Florian, additional, Vitko, Dijana, additional, Breitwieser, Florian P, additional, Müller, Lena, additional, Hassan, Hammad, additional, Bennett, Keiryn L, additional, Colinge, Jacques, additional, Schreiner, Wolfgang, additional, Egawa, Takeshi, additional, Taniuchi, Ichiro, additional, Matthias, Patrick, additional, Seiser, Christian, additional, and Ellmeier, Wilfried, additional

Published
2014
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4. Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

Author

Mucida, Daniel, primary, Husain, Mohammad Mushtaq, additional, Muroi, Sawako, additional, van Wijk, Femke, additional, Shinnakasu, Ryo, additional, Naoe, Yoshinori, additional, Reis, Bernardo Sgarbi, additional, Huang, Yujun, additional, Lambolez, Florence, additional, Docherty, Michael, additional, Attinger, Antoine, additional, Shui, Jr-Wen, additional, Kim, Gisen, additional, Lena, Christopher J, additional, Sakaguchi, Shinya, additional, Miyamoto, Chizuko, additional, Wang, Peng, additional, Atarashi, Koji, additional, Park, Yunji, additional, Nakayama, Toshinori, additional, Honda, Kenya, additional, Ellmeier, Wilfried, additional, Kronenberg, Mitchell, additional, Taniuchi, Ichiro, additional, and Cheroutre, Hilde, additional

Published
2013
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6. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

Author

Park, Jung-Hyun, primary, Adoro, Stanley, additional, Lucas, Philip J, additional, Sarafova, Sophia D, additional, Alag, Amala S, additional, Doan, Loretta L, additional, Erman, Batu, additional, Liu, Xiaolong, additional, Ellmeier, Wilfried, additional, Bosselut, Remy, additional, Feigenbaum, Lionel, additional, and Singer, Alfred, additional

Published
2007
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7. CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.

Author

Boucheron, Nicole, Tschismarov, Roland, Goeschl, Lisa, Moser, Mirjam A, Lagger, Sabine, Sakaguchi, Shinya, Winter, Mircea, Lenz, Florian, Vitko, Dijana, Breitwieser, Florian P, Müller, Lena, Hassan, Hammad, Bennett, Keiryn L, Colinge, Jacques, Schreiner, Wolfgang, Egawa, Takeshi, Taniuchi, Ichiro, Matthias, Patrick, Seiser, Christian, and Ellmeier, Wilfried

Subjects
HISTONE deacetylase regulation, CD4 antigen, T cells, T helper cells, MAJOR histocompatibility complex, CD8 antigen, RUNX proteins
Abstract

Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of major histocompatibility complex (MHC) class II-selected CD4+ helper T cells that expressed CD8-lineage genes such as Cd8a and Cd8b1. HDAC1 and HDAC2-deficient T helper type 0 (TH0) and TH1 cells further upregulated CD8-lineage genes and acquired a CD8+ effector T cell program in a manner dependent on Runx-CBFβ complexes, whereas TH2 cells repressed features of the CD8+ lineage independently of HDAC1 and HDAC2. These results demonstrate that HDAC1 and HDAC2 maintain integrity of the CD4 lineage by repressing Runx-CBFβ complexes that otherwise induce a CD8+ effector T cell-like program in CD4+ T cells. [ABSTRACT FROM AUTHOR]

Published
2014
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