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16 results on '"Zillikens M"'

1. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author: Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Soren, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Jr, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., and Hoed, Marcel den
Published: 2022
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2. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Author: Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., McCarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., and Lindgren, Cecilia M.
Published: 2019
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3. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author: Berndt, Sonja I, primary, Gustafsson, Stefan, additional, Mägi, Reedik, additional, Ganna, Andrea, additional, Wheeler, Eleanor, additional, Feitosa, Mary F, additional, Justice, Anne E, additional, Monda, Keri L, additional, Croteau-Chonka, Damien C, additional, Day, Felix R, additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U, additional, Luan, Jian'an, additional, Randall, Joshua C, additional, Vedantam, Sailaja, additional, Willer, Cristen J, additional, Winkler, Thomas W, additional, Wood, Andrew R, additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Lin, Dan-Yu, additional, Min, Josine L, additional, Neale, Benjamin M, additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L, additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E, additional, König, Inke R, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L, additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S, additional, Nolte, Ilja M, additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J, additional, Preuss, Michael, additional, Rose, Lynda M, additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J, additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D, additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vandenput, Liesbeth, additional, Waite, Lindsay L, additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W, additional, Atalay, Mustafa, additional, Attwood, Antony P, additional, Balmforth, Anthony J, additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L, additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I, additional, Chines, Peter S, additional, Collins, Francis S, additional, Connell, John M, additional, Cookson, William O, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M, additional, Farrall, Martin, additional, Ferrario, Marco M, additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V, additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S, additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Heath, Andrew C, additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B, additional, Hunt, Sarah E, additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B, additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimäki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T, additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H, additional, Lakka, Timo A, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A, additional, Magnusson, Patrik K, additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Mooser, Vincent, additional, Mühleisen, Thomas W, additional, Munroe, Patricia B, additional, Musk, Arthur W, additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A, additional, Ong, Ken K, additional, Oostra, Ben A, additional, Palmer, Colin N A, additional, Palotie, Aarno, additional, Peden, John F, additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P, additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E, additional, Sambrook, Jennifer G, additional, Sanders, Alan R, additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Stumvoll, Michael, additional, Swift, Amy J, additional, Theodoraki, Eirini V, additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M, additional, van Meurs, Joyce B J, additional, Vermeulen, Sita H, additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R, additional, Witteman, Jacqueline C M, additional, Wolffenbuttel, Bruce H R, additional, Wong, Andrew, additional, Wright, Alan F, additional, Zillikens, M Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Chanock, Stephen J, additional, Cupples, L Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Franks, Paul W, additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Hengstenberg, Christian, additional, Hicks, Andrew A, additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G, additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M, additional, Kiemeney, Lambertus A, additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F, additional, Martin, Nicholas G, additional, Metspalu, Andres, additional, Morris, Andrew D, additional, Nieminen, Markku S, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J, additional, Ouwehand, Willem H, additional, Palmer, Lyle J, additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M, additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Snieder, Harold, additional, Sørensen, Thorkild I A, additional, Spector, Timothy D, additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J, additional, Watkins, Hugh, additional, Wichmann, H-Erich, additional, Wilson, James F, additional, Abecasis, Goncalo R, additional, Assimes, Themistocles L, additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Fox, Caroline S, additional, Frayling, Timothy, additional, Groop, Leif C, additional, Haritunian, Talin, additional, Heid, Iris M, additional, Hunter, David, additional, Kaplan, Robert C, additional, Karpe, Fredrik, additional, Moffatt, Miriam F, additional, Mohlke, Karen L, additional, O'Connell, Jeffrey R, additional, Pawitan, Yudi, additional, Schadt, Eric E, additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Visscher, Peter M, additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I, additional, Speliotes, Elizabeth K, additional, North, Kari E, additional, Loos, Ruth J F, additional, and Ingelsson, Erik, additional
Published: 2013
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4. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Author: Estrada, Karol, primary, Styrkarsdottir, Unnur, additional, Evangelou, Evangelos, additional, Hsu, Yi-Hsiang, additional, Duncan, Emma L, additional, Ntzani, Evangelia E, additional, Oei, Ling, additional, Albagha, Omar M E, additional, Amin, Najaf, additional, Kemp, John P, additional, Koller, Daniel L, additional, Li, Guo, additional, Liu, Ching-Ti, additional, Minster, Ryan L, additional, Moayyeri, Alireza, additional, Vandenput, Liesbeth, additional, Willner, Dana, additional, Xiao, Su-Mei, additional, Yerges-Armstrong, Laura M, additional, Zheng, Hou-Feng, additional, Alonso, Nerea, additional, Eriksson, Joel, additional, Kammerer, Candace M, additional, Kaptoge, Stephen K, additional, Leo, Paul J, additional, Thorleifsson, Gudmar, additional, Wilson, Scott G, additional, Wilson, James F, additional, Aalto, Ville, additional, Alen, Markku, additional, Aragaki, Aaron K, additional, Aspelund, Thor, additional, Center, Jacqueline R, additional, Dailiana, Zoe, additional, Duggan, David J, additional, Garcia, Melissa, additional, Garcia-Giralt, Natàlia, additional, Giroux, Sylvie, additional, Hallmans, Göran, additional, Hocking, Lynne J, additional, Husted, Lise Bjerre, additional, Jameson, Karen A, additional, Khusainova, Rita, additional, Kim, Ghi Su, additional, Kooperberg, Charles, additional, Koromila, Theodora, additional, Kruk, Marcin, additional, Laaksonen, Marika, additional, Lacroix, Andrea Z, additional, Lee, Seung Hun, additional, Leung, Ping C, additional, Lewis, Joshua R, additional, Masi, Laura, additional, Mencej-Bedrac, Simona, additional, Nguyen, Tuan V, additional, Nogues, Xavier, additional, Patel, Millan S, additional, Prezelj, Janez, additional, Rose, Lynda M, additional, Scollen, Serena, additional, Siggeirsdottir, Kristin, additional, Smith, Albert V, additional, Svensson, Olle, additional, Trompet, Stella, additional, Trummer, Olivia, additional, van Schoor, Natasja M, additional, Woo, Jean, additional, Zhu, Kun, additional, Balcells, Susana, additional, Brandi, Maria Luisa, additional, Buckley, Brendan M, additional, Cheng, Sulin, additional, Christiansen, Claus, additional, Cooper, Cyrus, additional, Dedoussis, George, additional, Ford, Ian, additional, Frost, Morten, additional, Goltzman, David, additional, González-Macías, Jesús, additional, Kähönen, Mika, additional, Karlsson, Magnus, additional, Khusnutdinova, Elza, additional, Koh, Jung-Min, additional, Kollia, Panagoula, additional, Langdahl, Bente Lomholt, additional, Leslie, William D, additional, Lips, Paul, additional, Ljunggren, Östen, additional, Lorenc, Roman S, additional, Marc, Janja, additional, Mellström, Dan, additional, Obermayer-Pietsch, Barbara, additional, Olmos, José M, additional, Pettersson-Kymmer, Ulrika, additional, Reid, David M, additional, Riancho, José A, additional, Ridker, Paul M, additional, Rousseau, François, additional, lagboom, P Eline S, additional, Tang, Nelson L S, additional, Urreizti, Roser, additional, Van Hul, Wim, additional, Viikari, Jorma, additional, Zarrabeitia, María T, additional, Aulchenko, Yurii S, additional, Castano-Betancourt, Martha, additional, Grundberg, Elin, additional, Herrera, Lizbeth, additional, Ingvarsson, Thorvaldur, additional, Johannsdottir, Hrefna, additional, Kwan, Tony, additional, Li, Rui, additional, Luben, Robert, additional, Medina-Gómez, Carolina, additional, Th Palsson, Stefan, additional, Reppe, Sjur, additional, Rotter, Jerome I, additional, Sigurdsson, Gunnar, additional, van Meurs, Joyce B J, additional, Verlaan, Dominique, additional, Williams, Frances M K, additional, Wood, Andrew R, additional, Zhou, Yanhua, additional, Gautvik, Kaare M, additional, Pastinen, Tomi, additional, Raychaudhuri, Soumya, additional, Cauley, Jane A, additional, Chasman, Daniel I, additional, Clark, Graeme R, additional, Cummings, Steven R, additional, Danoy, Patrick, additional, Dennison, Elaine M, additional, Eastell, Richard, additional, Eisman, John A, additional, Gudnason, Vilmundur, additional, Hofman, Albert, additional, Jackson, Rebecca D, additional, Jones, Graeme, additional, Jukema, J Wouter, additional, Khaw, Kay-Tee, additional, Lehtimäki, Terho, additional, Liu, Yongmei, additional, Lorentzon, Mattias, additional, McCloskey, Eugene, additional, Mitchell, Braxton D, additional, Nandakumar, Kannabiran, additional, Nicholson, Geoffrey C, additional, Oostra, Ben A, additional, Peacock, Munro, additional, Pols, Huibert A P, additional, Prince, Richard L, additional, Raitakari, Olli, additional, Reid, Ian R, additional, Robbins, John, additional, Sambrook, Philip N, additional, Sham, Pak Chung, additional, Shuldiner, Alan R, additional, Tylavsky, Frances A, additional, van Duijn, Cornelia M, additional, Wareham, Nick J, additional, Cupples, L Adrienne, additional, Econs, Michael J, additional, Evans, David M, additional, Harris, Tamara B, additional, Kung, Annie Wai Chee, additional, Psaty, Bruce M, additional, Reeve, Jonathan, additional, Spector, Timothy D, additional, Streeten, Elizabeth A, additional, Zillikens, M Carola, additional, Thorsteinsdottir, Unnur, additional, Ohlsson, Claes, additional, Karasik, David, additional, Richards, J Brent, additional, Brown, Matthew A, additional, Stefansson, Kari, additional, Uitterlinden, André G, additional, Ralston, Stuart H, additional, Ioannidis, John P A, additional, Kiel, Douglas P, additional, and Rivadeneira, Fernando, additional
Published: 2012
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5. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Author: Stolk, Lisette, primary, Perry, John R B, additional, Chasman, Daniel I, additional, He, Chunyan, additional, Mangino, Massimo, additional, Sulem, Patrick, additional, Barbalic, Maja, additional, Broer, Linda, additional, Byrne, Enda M, additional, Ernst, Florian, additional, Esko, Tõnu, additional, Franceschini, Nora, additional, Gudbjartsson, Daniel F, additional, Hottenga, Jouke-Jan, additional, Kraft, Peter, additional, McArdle, Patrick F, additional, Porcu, Eleonora, additional, Shin, So-Youn, additional, Smith, Albert V, additional, van Wingerden, Sophie, additional, Zhai, Guangju, additional, Zhuang, Wei V, additional, Albrecht, Eva, additional, Alizadeh, Behrooz Z, additional, Aspelund, Thor, additional, Bandinelli, Stefania, additional, Lauc, Lovorka Barac, additional, Beckmann, Jacques S, additional, Boban, Mladen, additional, Boerwinkle, Eric, additional, Broekmans, Frank J, additional, Burri, Andrea, additional, Campbell, Harry, additional, Chanock, Stephen J, additional, Chen, Constance, additional, Cornelis, Marilyn C, additional, Corre, Tanguy, additional, Coviello, Andrea D, additional, d'Adamo, Pio, additional, Davies, Gail, additional, de Faire, Ulf, additional, de Geus, Eco J C, additional, Deary, Ian J, additional, Dedoussis, George V Z, additional, Deloukas, Panagiotis, additional, Ebrahim, Shah, additional, Eiriksdottir, Gudny, additional, Emilsson, Valur, additional, Eriksson, Johan G, additional, Fauser, Bart C J M, additional, Ferreli, Liana, additional, Ferrucci, Luigi, additional, Fischer, Krista, additional, Folsom, Aaron R, additional, Garcia, Melissa E, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Glazer, Nicole, additional, Grobbee, Diederick E, additional, Hall, Per, additional, Haller, Toomas, additional, Hankinson, Susan E, additional, Hass, Merli, additional, Hayward, Caroline, additional, Heath, Andrew C, additional, Hofman, Albert, additional, Ingelsson, Erik, additional, Janssens, A Cecile J W, additional, Johnson, Andrew D, additional, Karasik, David, additional, Kardia, Sharon L R, additional, Keyzer, Jules, additional, Kiel, Douglas P, additional, Kolcic, Ivana, additional, Kutalik, Zoltán, additional, Lahti, Jari, additional, Lai, Sandra, additional, Laisk, Triin, additional, Laven, Joop S E, additional, Lawlor, Debbie A, additional, Liu, Jianjun, additional, Lopez, Lorna M, additional, Louwers, Yvonne V, additional, Magnusson, Patrik K E, additional, Marongiu, Mara, additional, Martin, Nicholas G, additional, Klaric, Irena Martinovic, additional, Masciullo, Corrado, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Melzer, David, additional, Mooser, Vincent, additional, Navarro, Pau, additional, Newman, Anne B, additional, Nyholt, Dale R, additional, Onland-Moret, N Charlotte, additional, Palotie, Aarno, additional, Paré, Guillaume, additional, Parker, Alex N, additional, Pedersen, Nancy L, additional, Peeters, Petra H M, additional, Pistis, Giorgio, additional, Plump, Andrew S, additional, Polasek, Ozren, additional, Pop, Victor J M, additional, Psaty, Bruce M, additional, Räikkönen, Katri, additional, Rehnberg, Emil, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Sala, Cinzia, additional, Salumets, Andres, additional, Scuteri, Angelo, additional, Singleton, Andrew, additional, Smith, Jennifer A, additional, Snieder, Harold, additional, Soranzo, Nicole, additional, Stacey, Simon N, additional, Starr, John M, additional, Stathopoulou, Maria G, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Styrkarsdottir, Unnur, additional, Sun, Yan V, additional, Tenesa, Albert, additional, Thorand, Barbara, additional, Toniolo, Daniela, additional, Tryggvadottir, Laufey, additional, Tsui, Kim, additional, Ulivi, Sheila, additional, van Dam, Rob M, additional, van der Schouw, Yvonne T, additional, van Gils, Carla H, additional, van Nierop, Peter, additional, Vink, Jacqueline M, additional, Visscher, Peter M, additional, Voorhuis, Marlies, additional, Waeber, Gérard, additional, Wallaschofski, Henri, additional, Wichmann, H Erich, additional, Widen, Elisabeth, additional, Wijnands-van Gent, Colette J M, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wolffenbuttel, Bruce H R, additional, Wright, Alan F, additional, Yerges-Armstrong, Laura M, additional, Zemunik, Tatijana, additional, Zgaga, Lina, additional, Zillikens, M Carola, additional, Zygmunt, Marek, additional, Study, The LifeLines Cohort, additional, Arnold, Alice M, additional, Boomsma, Dorret I, additional, Buring, Julie E, additional, Crisponi, Laura, additional, Demerath, Ellen W, additional, Gudnason, Vilmundur, additional, Harris, Tamara B, additional, Hu, Frank B, additional, Hunter, David J, additional, Launer, Lenore J, additional, Metspalu, Andres, additional, Montgomery, Grant W, additional, Oostra, Ben A, additional, Ridker, Paul M, additional, Sanna, Serena, additional, Schlessinger, David, additional, Spector, Tim D, additional, Stefansson, Kari, additional, Streeten, Elizabeth A, additional, Thorsteinsdottir, Unnur, additional, Uda, Manuela, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, Völzke, Henry, additional, Murray, Anna, additional, Murabito, Joanne M, additional, Visser, Jenny A, additional, and Lunetta, Kathryn L, additional
Published: 2012
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6. Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author: Heid, Iris M, primary, Jackson, Anne U, additional, Randall, Joshua C, additional, Winkler, Thomas W, additional, Qi, Lu, additional, Steinthorsdottir, Valgerdur, additional, Thorleifsson, Gudmar, additional, Zillikens, M Carola, additional, Speliotes, Elizabeth K, additional, Mägi, Reedik, additional, Workalemahu, Tsegaselassie, additional, White, Charles C, additional, Bouatia-Naji, Nabila, additional, Harris, Tamara B, additional, Berndt, Sonja I, additional, Ingelsson, Erik, additional, Willer, Cristen J, additional, Weedon, Michael N, additional, Luan, Jian'an, additional, Vedantam, Sailaja, additional, Esko, Tõnu, additional, Kilpeläinen, Tuomas O, additional, Kutalik, Zoltán, additional, Li, Shengxu, additional, Monda, Keri L, additional, Dixon, Anna L, additional, Holmes, Christopher C, additional, Kaplan, Lee M, additional, Liang, Liming, additional, Min, Josine L, additional, Moffatt, Miriam F, additional, Molony, Cliona, additional, Nicholson, George, additional, Schadt, Eric E, additional, Zondervan, Krina T, additional, Feitosa, Mary F, additional, Ferreira, Teresa, additional, Allen, Hana Lango, additional, Weyant, Robert J, additional, Wheeler, Eleanor, additional, Wood, Andrew R, additional, Estrada, Karol, additional, Goddard, Michael E, additional, Lettre, Guillaume, additional, Mangino, Massimo, additional, Nyholt, Dale R, additional, Purcell, Shaun, additional, Vernon Smith, Albert, additional, Visscher, Peter M, additional, Yang, Jian, additional, McCarroll, Steven A, additional, Nemesh, James, additional, Voight, Benjamin F, additional, Absher, Devin, additional, Amin, Najaf, additional, Aspelund, Thor, additional, Coin, Lachlan, additional, Glazer, Nicole L, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Hottenga, Jouke-Jan, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kaakinen, Marika, additional, Kapur, Karen, additional, Ketkar, Shamika, additional, Knowles, Joshua W, additional, Kraft, Peter, additional, Kraja, Aldi T, additional, Lamina, Claudia, additional, Leitzmann, Michael F, additional, McKnight, Barbara, additional, Morris, Andrew P, additional, Ong, Ken K, additional, Perry, John R B, additional, Peters, Marjolein J, additional, Polasek, Ozren, additional, Prokopenko, Inga, additional, Rayner, Nigel W, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Robertson, Neil R, additional, Sanna, Serena, additional, Sovio, Ulla, additional, Surakka, Ida, additional, Teumer, Alexander, additional, van Wingerden, Sophie, additional, Vitart, Veronique, additional, Zhao, Jing Hua, additional, Cavalcanti-Proença, Christine, additional, Chines, Peter S, additional, Fisher, Eva, additional, Kulzer, Jennifer R, additional, Lecoeur, Cecile, additional, Narisu, Narisu, additional, Sandholt, Camilla, additional, Scott, Laura J, additional, Silander, Kaisa, additional, Stark, Klaus, additional, Tammesoo, Mari-Liis, additional, Teslovich, Tanya M, additional, Timpson, Nicholas John, additional, Watanabe, Richard M, additional, Welch, Ryan, additional, Chasman, Daniel I, additional, Cooper, Matthew N, additional, Jansson, John-Olov, additional, Kettunen, Johannes, additional, Lawrence, Robert W, additional, Pellikka, Niina, additional, Perola, Markus, additional, Vandenput, Liesbeth, additional, Alavere, Helene, additional, Almgren, Peter, additional, Atwood, Larry D, additional, Bennett, Amanda J, additional, Biffar, Reiner, additional, Bonnycastle, Lori L, additional, Bornstein, Stefan R, additional, Buchanan, Thomas A, additional, Campbell, Harry, additional, Day, Ian N M, additional, Dei, Mariano, additional, Dörr, Marcus, additional, Elliott, Paul, additional, Erdos, Michael R, additional, Eriksson, Johan G, additional, Freimer, Nelson B, additional, Fu, Mao, additional, Gaget, Stefan, additional, Geus, Eco J C, additional, Gjesing, Anette P, additional, Grallert, Harald, additional, Gräßler, Jürgen, additional, Groves, Christopher J, additional, Guiducci, Candace, additional, Hartikainen, Anna-Liisa, additional, Hassanali, Neelam, additional, Havulinna, Aki S, additional, Herzig, Karl-Heinz, additional, Hicks, Andrew A, additional, Hui, Jennie, additional, Igl, Wilmar, additional, Jousilahti, Pekka, additional, Jula, Antti, additional, Kajantie, Eero, additional, Kinnunen, Leena, additional, Kolcic, Ivana, additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Kroemer, Heyo K, additional, Krzelj, Vjekoslav, additional, Kuusisto, Johanna, additional, Kvaloy, Kirsti, additional, Laitinen, Jaana, additional, Lantieri, Olivier, additional, Lathrop, G Mark, additional, Lokki, Marja-Liisa, additional, Luben, Robert N, additional, Ludwig, Barbara, additional, McArdle, Wendy L, additional, McCarthy, Anne, additional, Morken, Mario A, additional, Nelis, Mari, additional, Neville, Matt J, additional, Paré, Guillaume, additional, Parker, Alex N, additional, Peden, John F, additional, Pichler, Irene, additional, Pietiläinen, Kirsi H, additional, Platou, Carl G P, additional, Pouta, Anneli, additional, Ridderstråle, Martin, additional, Samani, Nilesh J, additional, Saramies, Jouko, additional, Sinisalo, Juha, additional, Smit, Jan H, additional, Strawbridge, Rona J, additional, Stringham, Heather M, additional, Swift, Amy J, additional, Teder-Laving, Maris, additional, Thomson, Brian, additional, Usala, Gianluca, additional, van Meurs, Joyce B J, additional, van Ommen, Gert-Jan, additional, Vatin, Vincent, additional, Volpato, Claudia B, additional, Wallaschofski, Henri, additional, Walters, G Bragi, additional, Widen, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Witte, Daniel R, additional, Zgaga, Lina, additional, Zitting, Paavo, additional, Beilby, John P, additional, James, Alan L, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Nieminen, Markku S, additional, Ohlsson, Claes, additional, Palmer, Lyle J, additional, Raitakari, Olli, additional, Ridker, Paul M, additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Viikari, Jorma, additional, Balkau, Beverley, additional, Ben-Shlomo, Yoav, additional, Bergman, Richard N, additional, Boeing, Heiner, additional, Smith, George Davey, additional, Ebrahim, Shah, additional, Froguel, Philippe, additional, Hansen, Torben, additional, Hengstenberg, Christian, additional, Hveem, Kristian, additional, Isomaa, Bo, additional, Jørgensen, Torben, additional, Karpe, Fredrik, additional, Khaw, Kay-Tee, additional, Laakso, Markku, additional, Lawlor, Debbie A, additional, Marre, Michel, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Midthjell, Kristian, additional, Pedersen, Oluf, additional, Salomaa, Veikko, additional, Schwarz, Peter E H, additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Valle, Timo T, additional, Wareham, Nicholas J, additional, Arnold, Alice M, additional, Beckmann, Jacques S, additional, Bergmann, Sven, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Collins, Francis S, additional, Eiriksdottir, Gudny, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Hattersley, Andrew T, additional, Hofman, Albert, additional, Hu, Frank B, additional, Illig, Thomas, additional, Iribarren, Carlos, additional, Jarvelin, Marjo-Riitta, additional, Kao, W H Linda, additional, Kaprio, Jaakko, additional, Launer, Lenore J, additional, Munroe, Patricia B, additional, Oostra, Ben, additional, Penninx, Brenda W, additional, Pramstaller, Peter P, additional, Psaty, Bruce M, additional, Quertermous, Thomas, additional, Rissanen, Aila, additional, Rudan, Igor, additional, Shuldiner, Alan R, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Syvanen, Ann-Christine, additional, Uda, Manuela, additional, Uitterlinden, André, additional, Völzke, Henry, additional, Vollenweider, Peter, additional, Wilson, James F, additional, Witteman, Jacqueline C, additional, Wright, Alan F, additional, Abecasis, Gonçalo R, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Frayling, Timothy M, additional, Groop, Leif C, additional, Haritunians, Talin, additional, Hunter, David J, additional, Kaplan, Robert C, additional, North, Kari E, additional, O'Connell, Jeffrey R, additional, Peltonen, Leena, additional, Schlessinger, David, additional, Strachan, David P, additional, Hirschhorn, Joel N, additional, Assimes, Themistocles L, additional, Wichmann, H-Erich, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Stefansson, Kari, additional, Cupples, L Adrienne, additional, Loos, Ruth J F, additional, Barroso, Inês, additional, McCarthy, Mark I, additional, Fox, Caroline S, additional, Mohlke, Karen L, additional, and Lindgren, Cecilia M, additional
Published: 2011
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7. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Author: Kilpeläinen, Tuomas O, primary, Zillikens, M Carola, additional, Stančákova, Alena, additional, Finucane, Francis M, additional, Ried, Janina S, additional, Langenberg, Claudia, additional, Zhang, Weihua, additional, Beckmann, Jacques S, additional, Luan, Jian'an, additional, Vandenput, Liesbeth, additional, Styrkarsdottir, Unnur, additional, Zhou, Yanhua, additional, Smith, Albert Vernon, additional, Zhao, Jing-Hua, additional, Amin, Najaf, additional, Vedantam, Sailaja, additional, Shin, So-Youn, additional, Haritunians, Talin, additional, Fu, Mao, additional, Feitosa, Mary F, additional, Kumari, Meena, additional, Halldorsson, Bjarni V, additional, Tikkanen, Emmi, additional, Mangino, Massimo, additional, Hayward, Caroline, additional, Song, Ci, additional, Arnold, Alice M, additional, Aulchenko, Yurii S, additional, Oostra, Ben A, additional, Campbell, Harry, additional, Cupples, L Adrienne, additional, Davis, Kathryn E, additional, Döring, Angela, additional, Eiriksdottir, Gudny, additional, Estrada, Karol, additional, Fernández-Real, José Manuel, additional, Garcia, Melissa, additional, Gieger, Christian, additional, Glazer, Nicole L, additional, Guiducci, Candace, additional, Hofman, Albert, additional, Humphries, Steve E, additional, Isomaa, Bo, additional, Jacobs, Leonie C, additional, Jula, Antti, additional, Karasik, David, additional, Karlsson, Magnus K, additional, Khaw, Kay-Tee, additional, Kim, Lauren J, additional, Kivimäki, Mika, additional, Klopp, Norman, additional, Kühnel, Brigitte, additional, Kuusisto, Johanna, additional, Liu, Yongmei, additional, Ljunggren, Östen, additional, Lorentzon, Mattias, additional, Luben, Robert N, additional, McKnight, Barbara, additional, Mellström, Dan, additional, Mitchell, Braxton D, additional, Mooser, Vincent, additional, Moreno, José Maria, additional, Männistö, Satu, additional, O'Connell, Jeffery R, additional, Pascoe, Laura, additional, Peltonen, Leena, additional, Peral, Belén, additional, Perola, Markus, additional, Psaty, Bruce M, additional, Salomaa, Veikko, additional, Savage, David B, additional, Semple, Robert K, additional, Skaric-Juric, Tatjana, additional, Sigurdsson, Gunnar, additional, Song, Kijoung S, additional, Spector, Timothy D, additional, Syvänen, Ann-Christine, additional, Talmud, Philippa J, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, Vidal-Puig, Antonio, additional, Wild, Sarah H, additional, Wright, Alan F, additional, Clegg, Deborah J, additional, Schadt, Eric, additional, Wilson, James F, additional, Rudan, Igor, additional, Ripatti, Samuli, additional, Borecki, Ingrid B, additional, Shuldiner, Alan R, additional, Ingelsson, Erik, additional, Jansson, John-Olov, additional, Kaplan, Robert C, additional, Gudnason, Vilmundur, additional, Harris, Tamara B, additional, Groop, Leif, additional, Kiel, Douglas P, additional, Rivadeneira, Fernando, additional, Walker, Mark, additional, Barroso, Inês, additional, Vollenweider, Peter, additional, Waeber, Gérard, additional, Chambers, John C, additional, Kooner, Jaspal S, additional, Soranzo, Nicole, additional, Hirschhorn, Joel N, additional, Stefansson, Kari, additional, Wichmann, H-Erich, additional, Ohlsson, Claes, additional, O'Rahilly, Stephen, additional, Wareham, Nicholas J, additional, Speliotes, Elizabeth K, additional, Fox, Caroline S, additional, Laakso, Markku, additional, and Loos, Ruth J F, additional
Published: 2011
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8. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Author: Dupuis, Josée, primary, Langenberg, Claudia, additional, Prokopenko, Inga, additional, Saxena, Richa, additional, Soranzo, Nicole, additional, Jackson, Anne U, additional, Wheeler, Eleanor, additional, Glazer, Nicole L, additional, Bouatia-Naji, Nabila, additional, Gloyn, Anna L, additional, Lindgren, Cecilia M, additional, Mägi, Reedik, additional, Morris, Andrew P, additional, Randall, Joshua, additional, Johnson, Toby, additional, Elliott, Paul, additional, Rybin, Denis, additional, Thorleifsson, Gudmar, additional, Steinthorsdottir, Valgerdur, additional, Henneman, Peter, additional, Grallert, Harald, additional, Dehghan, Abbas, additional, Hottenga, Jouke Jan, additional, Franklin, Christopher S, additional, Navarro, Pau, additional, Song, Kijoung, additional, Goel, Anuj, additional, Perry, John R B, additional, Egan, Josephine M, additional, Lajunen, Taina, additional, Grarup, Niels, additional, Sparsø, Thomas, additional, Doney, Alex, additional, Voight, Benjamin F, additional, Stringham, Heather M, additional, Li, Man, additional, Kanoni, Stavroula, additional, Shrader, Peter, additional, Cavalcanti-Proença, Christine, additional, Kumari, Meena, additional, Qi, Lu, additional, Timpson, Nicholas J, additional, Gieger, Christian, additional, Zabena, Carina, additional, Rocheleau, Ghislain, additional, Ingelsson, Erik, additional, An, Ping, additional, O'Connell, Jeffrey, additional, Luan, Jian'an, additional, Elliott, Amanda, additional, McCarroll, Steven A, additional, Payne, Felicity, additional, Roccasecca, Rosa Maria, additional, Pattou, François, additional, Sethupathy, Praveen, additional, Ardlie, Kristin, additional, Ariyurek, Yavuz, additional, Balkau, Beverley, additional, Barter, Philip, additional, Beilby, John P, additional, Ben-Shlomo, Yoav, additional, Benediktsson, Rafn, additional, Bennett, Amanda J, additional, Bergmann, Sven, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Bonnefond, Amélie, additional, Bonnycastle, Lori L, additional, Borch-Johnsen, Knut, additional, Böttcher, Yvonne, additional, Brunner, Eric, additional, Bumpstead, Suzannah J, additional, Charpentier, Guillaume, additional, Chen, Yii-Der Ida, additional, Chines, Peter, additional, Clarke, Robert, additional, Coin, Lachlan J M, additional, Cooper, Matthew N, additional, Cornelis, Marilyn, additional, Crawford, Gabe, additional, Crisponi, Laura, additional, Day, Ian N M, additional, de Geus, Eco J C, additional, Delplanque, Jerome, additional, Dina, Christian, additional, Erdos, Michael R, additional, Fedson, Annette C, additional, Fischer-Rosinsky, Antje, additional, Forouhi, Nita G, additional, Fox, Caroline S, additional, Frants, Rune, additional, Franzosi, Maria Grazia, additional, Galan, Pilar, additional, Goodarzi, Mark O, additional, Graessler, Jürgen, additional, Groves, Christopher J, additional, Grundy, Scott, additional, Gwilliam, Rhian, additional, Gyllensten, Ulf, additional, Hadjadj, Samy, additional, Hallmans, Göran, additional, Hammond, Naomi, additional, Han, Xijing, additional, Hartikainen, Anna-Liisa, additional, Hassanali, Neelam, additional, Hayward, Caroline, additional, Heath, Simon C, additional, Hercberg, Serge, additional, Herder, Christian, additional, Hicks, Andrew A, additional, Hillman, David R, additional, Hingorani, Aroon D, additional, Hofman, Albert, additional, Hui, Jennie, additional, Hung, Joe, additional, Isomaa, Bo, additional, Johnson, Paul R V, additional, Jørgensen, Torben, additional, Jula, Antti, additional, Kaakinen, Marika, additional, Kaprio, Jaakko, additional, Kesaniemi, Y Antero, additional, Kivimaki, Mika, additional, Knight, Beatrice, additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Kyvik, Kirsten Ohm, additional, Lathrop, G Mark, additional, Lawlor, Debbie A, additional, Le Bacquer, Olivier, additional, Lecoeur, Cécile, additional, Li, Yun, additional, Lyssenko, Valeriya, additional, Mahley, Robert, additional, Mangino, Massimo, additional, Manning, Alisa K, additional, Martínez-Larrad, María Teresa, additional, McAteer, Jarred B, additional, McCulloch, Laura J, additional, McPherson, Ruth, additional, Meisinger, Christa, additional, Melzer, David, additional, Meyre, David, additional, Mitchell, Braxton D, additional, Morken, Mario A, additional, Mukherjee, Sutapa, additional, Naitza, Silvia, additional, Narisu, Narisu, additional, Neville, Matthew J, additional, Oostra, Ben A, additional, Orrù, Marco, additional, Pakyz, Ruth, additional, Palmer, Colin N A, additional, Paolisso, Giuseppe, additional, Pattaro, Cristian, additional, Pearson, Daniel, additional, Peden, John F, additional, Pedersen, Nancy L, additional, Perola, Markus, additional, Pfeiffer, Andreas F H, additional, Pichler, Irene, additional, Polasek, Ozren, additional, Posthuma, Danielle, additional, Potter, Simon C, additional, Pouta, Anneli, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Rathmann, Wolfgang, additional, Rayner, Nigel W, additional, Rice, Kenneth, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Roden, Michael, additional, Rolandsson, Olov, additional, Sandbaek, Annelli, additional, Sandhu, Manjinder, additional, Sanna, Serena, additional, Sayer, Avan Aihie, additional, Scheet, Paul, additional, Scott, Laura J, additional, Seedorf, Udo, additional, Sharp, Stephen J, additional, Shields, Beverley, additional, SigurÐsson, Gunnar, additional, Sijbrands, Eric J G, additional, Silveira, Angela, additional, Simpson, Laila, additional, Singleton, Andrew, additional, Smith, Nicholas L, additional, Sovio, Ulla, additional, Swift, Amy, additional, Syddall, Holly, additional, Syvänen, Ann-Christine, additional, Tanaka, Toshiko, additional, Thorand, Barbara, additional, Tichet, Jean, additional, Tönjes, Anke, additional, Tuomi, Tiinamaija, additional, Uitterlinden, André G, additional, van Dijk, Ko Willems, additional, van Hoek, Mandy, additional, Varma, Dhiraj, additional, Visvikis-Siest, Sophie, additional, Vitart, Veronique, additional, Vogelzangs, Nicole, additional, Waeber, Gérard, additional, Wagner, Peter J, additional, Walley, Andrew, additional, Walters, G Bragi, additional, Ward, Kim L, additional, Watkins, Hugh, additional, Weedon, Michael N, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Witteman, Jaqueline C M, additional, Yarnell, John W G, additional, Zeggini, Eleftheria, additional, Zelenika, Diana, additional, Zethelius, Björn, additional, Zhai, Guangju, additional, Zhao, Jing Hua, additional, Zillikens, M Carola, additional, Consortium, DIAGRAM, additional, Consortium, GIANT, additional, Consortium, Global BPgen, additional, Borecki, Ingrid B, additional, Loos, Ruth J F, additional, Meneton, Pierre, additional, Magnusson, Patrik K E, additional, Nathan, David M, additional, Williams, Gordon H, additional, Hattersley, Andrew T, additional, Silander, Kaisa, additional, Salomaa, Veikko, additional, Smith, George Davey, additional, Bornstein, Stefan R, additional, Schwarz, Peter, additional, Spranger, Joachim, additional, Karpe, Fredrik, additional, Shuldiner, Alan R, additional, Cooper, Cyrus, additional, Dedoussis, George V, additional, Serrano-Ríos, Manuel, additional, Morris, Andrew D, additional, Lind, Lars, additional, Palmer, Lyle J, additional, Hu, Frank B, additional, Franks, Paul W, additional, Ebrahim, Shah, additional, Marmot, Michael, additional, Kao, W H Linda, additional, Pankow, James S, additional, Sampson, Michael J, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Pramstaller, Peter Paul, additional, Wichmann, H Erich, additional, Illig, Thomas, additional, Rudan, Igor, additional, Wright, Alan F, additional, Stumvoll, Michael, additional, Campbell, Harry, additional, Wilson, James F, additional, Hamsten, Anders, additional, Bergman, Richard N, additional, Buchanan, Thomas A, additional, Collins, Francis S, additional, Mohlke, Karen L, additional, Tuomilehto, Jaakko, additional, Valle, Timo T, additional, Altshuler, David, additional, Rotter, Jerome I, additional, Siscovick, David S, additional, Penninx, Brenda W J H, additional, Boomsma, Dorret I, additional, Deloukas, Panos, additional, Spector, Timothy D, additional, Frayling, Timothy M, additional, Ferrucci, Luigi, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, van Duijn, Cornelia M, additional, Aulchenko, Yurii S, additional, Cao, Antonio, additional, Scuteri, Angelo, additional, Schlessinger, David, additional, Uda, Manuela, additional, Ruokonen, Aimo, additional, Jarvelin, Marjo-Riitta, additional, Waterworth, Dawn M, additional, Vollenweider, Peter, additional, Peltonen, Leena, additional, Mooser, Vincent, additional, Abecasis, Goncalo R, additional, Wareham, Nicholas J, additional, Sladek, Robert, additional, Froguel, Philippe, additional, Watanabe, Richard M, additional, Meigs, James B, additional, Groop, Leif, additional, Boehnke, Michael, additional, McCarthy, Mark I, additional, Florez, Jose C, additional, and Barroso, Inês, additional
Published: 2010
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9. New loci associated with kidney function and chronic kidney disease

Author: Köttgen, Anna, primary, Pattaro, Cristian, additional, Böger, Carsten A, additional, Fuchsberger, Christian, additional, Olden, Matthias, additional, Glazer, Nicole L, additional, Parsa, Afshin, additional, Gao, Xiaoyi, additional, Yang, Qiong, additional, Smith, Albert V, additional, O'Connell, Jeffrey R, additional, Li, Man, additional, Schmidt, Helena, additional, Tanaka, Toshiko, additional, Isaacs, Aaron, additional, Ketkar, Shamika, additional, Hwang, Shih-Jen, additional, Johnson, Andrew D, additional, Dehghan, Abbas, additional, Teumer, Alexander, additional, Paré, Guillaume, additional, Atkinson, Elizabeth J, additional, Zeller, Tanja, additional, Lohman, Kurt, additional, Cornelis, Marilyn C, additional, Probst-Hensch, Nicole M, additional, Kronenberg, Florian, additional, Tönjes, Anke, additional, Hayward, Caroline, additional, Aspelund, Thor, additional, Eiriksdottir, Gudny, additional, Launer, Lenore J, additional, Harris, Tamara B, additional, Rampersaud, Evadnie, additional, Mitchell, Braxton D, additional, Arking, Dan E, additional, Boerwinkle, Eric, additional, Struchalin, Maksim, additional, Cavalieri, Margherita, additional, Singleton, Andrew, additional, Giallauria, Francesco, additional, Metter, Jeffrey, additional, de Boer, Ian H, additional, Haritunians, Talin, additional, Lumley, Thomas, additional, Siscovick, David, additional, Psaty, Bruce M, additional, Zillikens, M Carola, additional, Oostra, Ben A, additional, Feitosa, Mary, additional, Province, Michael, additional, de Andrade, Mariza, additional, Turner, Stephen T, additional, Schillert, Arne, additional, Ziegler, Andreas, additional, Wild, Philipp S, additional, Schnabel, Renate B, additional, Wilde, Sandra, additional, Munzel, Thomas F, additional, Leak, Tennille S, additional, Illig, Thomas, additional, Klopp, Norman, additional, Meisinger, Christa, additional, Wichmann, H-Erich, additional, Koenig, Wolfgang, additional, Zgaga, Lina, additional, Zemunik, Tatijana, additional, Kolcic, Ivana, additional, Minelli, Cosetta, additional, Hu, Frank B, additional, Johansson, Åsa, additional, Igl, Wilmar, additional, Zaboli, Ghazal, additional, Wild, Sarah H, additional, Wright, Alan F, additional, Campbell, Harry, additional, Ellinghaus, David, additional, Schreiber, Stefan, additional, Aulchenko, Yurii S, additional, Felix, Janine F, additional, Rivadeneira, Fernando, additional, Uitterlinden, Andre G, additional, Hofman, Albert, additional, Imboden, Medea, additional, Nitsch, Dorothea, additional, Brandstätter, Anita, additional, Kollerits, Barbara, additional, Kedenko, Lyudmyla, additional, Mägi, Reedik, additional, Stumvoll, Michael, additional, Kovacs, Peter, additional, Boban, Mladen, additional, Campbell, Susan, additional, Endlich, Karlhans, additional, Völzke, Henry, additional, Kroemer, Heyo K, additional, Nauck, Matthias, additional, Völker, Uwe, additional, Polasek, Ozren, additional, Vitart, Veronique, additional, Badola, Sunita, additional, Parker, Alexander N, additional, Ridker, Paul M, additional, Kardia, Sharon L R, additional, Blankenberg, Stefan, additional, Liu, Yongmei, additional, Curhan, Gary C, additional, Franke, Andre, additional, Rochat, Thierry, additional, Paulweber, Bernhard, additional, Prokopenko, Inga, additional, Wang, Wei, additional, Gudnason, Vilmundur, additional, Shuldiner, Alan R, additional, Coresh, Josef, additional, Schmidt, Reinhold, additional, Ferrucci, Luigi, additional, Shlipak, Michael G, additional, van Duijn, Cornelia M, additional, Borecki, Ingrid, additional, Krämer, Bernhard K, additional, Rudan, Igor, additional, Gyllensten, Ulf, additional, Wilson, James F, additional, Witteman, Jacqueline C, additional, Pramstaller, Peter P, additional, Rettig, Rainer, additional, Hastie, Nick, additional, Chasman, Daniel I, additional, Kao, W H, additional, Heid, Iris M, additional, and Fox, Caroline S, additional
Published: 2010
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10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Author: Heid, Iris M., Jackson, Anne U., Randall, Joshua C., Winkler, Thomas W., Lu Qi, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M. Carola, Speliotes, Elizabeth K., Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C., Bouatia-Naji, Nabila, Harris, Tamara B., Berndt, Sonja I., Ingelsson, Erik, Willer, Cristen J., Weedon, Michael N., Luan, Jian'an, and Vedantam, Sailaja
Subjects: WAIST-hip ratio, META-analysis, LOCUS (Genetics), SEXUAL dimorphism in animals, ADIPOSE tissues
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. [ABSTRACT FROM AUTHOR]
Published: 2010
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11. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

Author: Rivadeneira, Fernando, Styrkársdottir, Unnur, Estrada, Karol, Halldórsson, Bjarni V., Yi-Hsiang Hsu, Richards, J. Brent, Zillikens, M. Carola, Kavvoura, Fotini K., Amin, Najaf, Aulchenko, Yurii S., Cupples, L. Adrienne, Deloukas, Panagiotis, Demissie, Serkalem, Grundberg, Elin, Hofman, Albert, Kong, Augustine, Karasik, David, van Meurs, Joyce B., Oostra, Ben, and Pastinen, Tomi
Subjects: BONE density, GENOMES, OSTEOPOROSIS, BONE diseases, META-analysis
Abstract: Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 × 10−8), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD. [ABSTRACT FROM AUTHOR]
Published: 2009
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12. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Author: Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Angelantonio, Emanuele Di, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O'Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CH, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Internal Medicine, Epidemiology, Obstetrics & Gynecology, Radiology & Nuclear Medicine, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Institute for Molecular Medicine Finland, Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki, Young, Kristin L [0000-0003-0070-6145], Mahajan, Anubha [0000-0001-5585-3420], Winkler, Thomas W [0000-0003-0292-5421], Locke, Adam E [0000-0001-6227-198X], Medina-Gomez, Carolina [0000-0001-7999-5538], Giri, Ayush [0000-0002-7786-4670], Ng, Maggie CY [0000-0002-4133-2007], Heard-Costa, Nancy L [0000-0001-9730-0306], Manning, Alisa K [0000-0003-0247-902X], Alam, Dewan S [0000-0002-2051-3837], Amouyel, Philippe [0000-0001-9088-234X], Bergmann, Sven [0000-0002-6785-9034], Boehnke, Michael [0000-0002-6442-7754], Butterworth, Adam S [0000-0002-6915-9015], Caulfield, Mark J [0000-0001-9295-3594], Collins, Francis S [0000-0002-1023-7410], de Bakker, Paul IW [0000-0001-7735-7858], Dennis, Joe G [0000-0003-4591-1214], Easton, Douglas F [0000-0003-2444-3247], Elliott, Paul [0000-0002-7511-5684], Evangelou, Evangelos [0000-0002-5488-2999], Giedraitis, Vilmantas [0000-0003-3423-2021], Girotto, Giorgia [0000-0003-4507-6589], Grarup, Niels [0000-0001-5526-1070], Gustafsson, Stefan [0000-0001-5894-0351], Hansen, Torben [0000-0001-8748-3831], Hayward, Caroline [0000-0002-9405-9550], Howson, Joanna MM [0000-0001-7618-0050], Ikram, M Arfan [0000-0003-0372-8585], Jackson, Anne U [0000-0002-9672-2547], Justesen, Johanne M [0000-0002-0484-8522], Kovacs, Peter [0000-0002-0290-5423], Kuulasmaa, Kari [0000-0003-2165-1411], Langenberg, Claudia [0000-0002-5017-7344], Lin, Li-An [0000-0003-2731-1346], Linneberg, Allan [0000-0002-0994-0184], Liu, Ching-Ti [0000-0002-0703-0742], Lyytikäinen, Leo-Pekka [0000-0002-7200-5455], MacGregor, Stuart [0000-0001-6731-8142], McCarthy, Mark I [0000-0002-4393-0510], Morgan, Anna [0000-0001-6290-445X], Müller-Nurasyid, Martina [0000-0003-3793-5910], Munroe, Patricia B [0000-0002-4176-2947], Narisu, Narisu [0000-0002-8483-1156], Neville, Matt [0000-0002-6004-5433], Reilly, Dermot F [0000-0002-9456-1364], Rudan, Igor [0000-0001-6993-6884], Saleheen, Danish [0000-0001-6193-020X], Salomaa, Veikko [0000-0001-7563-5324], Sim, Xueling [0000-0002-1233-7642], Small, Kerrin S [0000-0003-4566-0005], Smith, Blair H [0000-0002-5362-9430], Smith, Jennifer A [0000-0002-3575-5468], Southam, Lorraine [0000-0002-7546-9650], Stefansson, Kari [0000-0003-1676-864X], Stirrups, Kathleen E [0000-0002-6823-3252], Stringham, Heather M [0000-0002-2991-6392], Teumer, Alexander [0000-0002-8309-094X], Thompson, Deborah J [0000-0003-1465-5799], Vestergaard, Henrik [0000-0003-3090-269X], Vitart, Veronique [0000-0002-4991-3797], Wang, Carol A [0000-0002-4301-3974], Wessel, Jennifer [0000-0002-7031-0085], Willer, Cristen J [0000-0001-5645-4966], Zeggini, Eleftheria [0000-0003-4238-659X], Rivadeneira, Fernando [0000-0001-9435-9441], Pospisilik, J Andrew [0000-0002-9745-0977], Deloukas, Panos [0000-0001-9251-070X], Mohlke, Karen L [0000-0001-6721-153X], Kutalik, Zoltán [0000-0001-8285-7523], Loos, Ruth JF [0000-0002-8532-5087], Lindgren, Cecilia M [0000-0002-4903-9374], Apollo - University of Cambridge Repository, Home Office, Medical Research Council (MRC), National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, UK DRI Ltd, Medical and Clinical Psychology, Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthia, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Angelantonio, Emanuele Di, Dörr, Marcu, Drenos, Fotio, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelo, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmanta, Girotto, Giorgia, Gorski, Mathia, Grallert, Harald, Grarup, Niel, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kee, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lar, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’An, Lyytikäinen, Leo-Pekka, Macgregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., Mccarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Marku, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lar, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Pano, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., Lindgren, Cecilia M., APH - Societal Participation & Health, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, Epidemiology and Data Science, and VU University medical center
Subjects: Exome/genetics, Male, ReproGen Consortium, Adipose tissue, Genome-wide association study, Type 2 diabetes, White adipose tissue, Body Mass Index, Animals, Body Fat Distribution, Case-Control Studies, Drosophila, Exome, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Homeostasis, Humans, Lipids, Proteins, Risk Factors, Waist-Hip Ratio, 0302 clinical medicine, Hyperlipidemia, Body fat distribution, 2. Zero hunger, Genetics, 0303 health sciences, INSULIN-RESISTANCE, ADIPOCYTE DIFFERENTIATION, CHD Exome+ Consortium, Genetic Predisposition to Disease/genetics, Drosophila/genetics, RS11209026 POLYMORPHISM, KINASE 7, 1184 Genetics, developmental biology, physiology, T2D-Genes Consortium, 11 Medical And Health Sciences, Body Fat Distribution/methods, RECEPTOR ALK7, ADIPOSE-TISSUE, Gene Frequency/genetics, Genetic Variation/genetics, InterAct, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], genetic association study, RNA splicing, Proteins/genetics, Genome-Wide Association Study/methods, Lipid particle, ExomeBP Consortium, WAIST CIRCUMFERENCE, Waist-Hip Ratio/methods, Biology, EPIC-CVD Consortium, Article, MAGIC Investigators, 03 medical and health sciences, Homeostasis/genetics, Lipids/genetics, All institutes and research themes of the Radboud University Medical Center, medicine, Global Lipids Genetic Consortium, Risk factor, GENOME-WIDE ASSOCIATION, ABDOMINAL ADIPOSITY, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Gene, 030304 developmental biology, 06 Biological Sciences, medicine.disease, Minor allele frequency, GoT2D Genes Consortium, genetics research, TYPE-2 DIABETES SUSCEPTIBILITY, 3111 Biomedicine, Body mass index, 030217 neurology & neurosurgery, Developmental Biology
Abstract: Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥ 5%) and 9 low frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology, and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants., Editorial summary: A trans-ethnic exome-wide association study for body fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.
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13. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Author: Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, and Vedantam, Sailaja
Subjects: GENE frequency, GENETIC polymorphisms, SEXUAL dimorphism, META-analysis
Abstract: Corrections to the article "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution" that was published in the October 10, 2011 issue are presented, such as the effect allele frequencies for eight single nucleotide polymorphisms (SNPs) that include rs984222, rs9491696, and rs4846567.
Published: 2011
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14. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Author: Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proença C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, den Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Grässler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, Jørgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimäki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B, Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A, McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K, Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Paré G, Parker AN, Perola M, Pichler I, Pietiläinen KH, Platou CG, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstråle M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, Tönjes A, Tuomi T, van Meurs JB, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI, Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, Kähönen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Grönberg H, Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB, Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A, Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I, Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ, Watkins H, Wilson JF, Wright AF, Zillikens MC, Chatterjee N, McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL, Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Wichmann HE, Frayling TM, Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson K, North KE, McCarthy MI, Hirschhorn JN, Ingelsson E, and Loos RJ
Subjects: Body Size genetics, Genetic Predisposition to Disease genetics, Genome-Wide Association Study, Humans, Obesity genetics, Polymorphism, Single Nucleotide, White People genetics, Body Height genetics, Body Mass Index, Body Weight genetics, Chromosome Mapping
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Published: 2010
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15. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Author: Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JR, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day IN, de Geus EJ, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen AL, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PR, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, and Barroso I
Subjects: Adolescent, Adult, Alleles, Child, DNA Copy Number Variations genetics, Databases, Genetic, Delta-5 Fatty Acid Desaturase, Gene Expression Regulation, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide genetics, Quantitative Trait Loci genetics, Quantitative Trait, Heritable, Reproducibility of Results, Blood Glucose genetics, Blood Glucose metabolism, Diabetes Mellitus, Type 2 genetics, Fasting blood, Genetic Loci genetics, Genetic Predisposition to Disease, Homeostasis genetics
Abstract: Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Published: 2010
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16. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Author: Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, and Hirschhorn JN
Subjects: Alleles, Anthropometry, Cohort Studies, Gene Dosage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Obesity complications, Obesity genetics, Polymorphism, Single Nucleotide genetics, Quantitative Trait, Heritable, Body Mass Index, Body Weight genetics, Central Nervous System physiology, Quantitative Trait Loci genetics
Abstract: Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Published: 2009
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16 results on '"Zillikens M"'

1. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

2. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

3. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

4. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

5. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

6. Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

7. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

8. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

9. New loci associated with kidney function and chronic kidney disease

10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

11. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

12. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

13. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

14. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

15. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

16. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

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16 results on '"Zillikens M"'

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