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Your search keyword '"Olshen, Adam B"' showing total 6 results
Start Over Author "Olshen, Adam B" Journal nature genetics
6 results on '"Olshen, Adam B"'

1. Correction: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

Author

Stieglitz, Elliot, primary, Taylor-Weiner, Amaro N, additional, Chang, Tiffany Y, additional, Gelston, Laura C, additional, Wang, Yong-Dong, additional, Mazor, Tali, additional, Esquivel, Emilio, additional, Yu, Ariel, additional, Seepo, Sara, additional, Olsen, Scott R, additional, Rosenberg, Mara, additional, Archambeault, Sophie L, additional, Abusin, Ghada, additional, Beckman, Kyle, additional, Brown, Patrick A, additional, Briones, Michael, additional, Carcamo, Benjamin, additional, Cooper, Todd, additional, Dahl, Gary V, additional, Emanuel, Peter D, additional, Fluchel, Mark N, additional, Goyal, Rakesh K, additional, Hayashi, Robert J, additional, Hitzler, Johann, additional, Hugge, Christopher, additional, Liu, Y Lucy, additional, Messinger, Yoav H, additional, Mahoney, Donald H, additional, Monteleone, Philip, additional, Nemecek, Eneida R, additional, Roehrs, Philip A, additional, Schore, Reuven J, additional, Stine, Kimo C, additional, Takemoto, Clifford M, additional, Toretsky, Jeffrey A, additional, Costello, Joseph F, additional, Olshen, Adam B, additional, Stewart, Chip, additional, Li, Yongjin, additional, Ma, Jing, additional, Gerbing, Robert B, additional, Alonzo, Todd A, additional, Getz, Gad, additional, Gruber, Tanja A, additional, Golub, Todd R, additional, Stegmaier, Kimberly, additional, and Loh, Mignon L, additional

Published
2016
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2. The genomic landscape of juvenile myelomonocytic leukemia

Author

Stieglitz, Elliot, primary, Taylor-Weiner, Amaro N, additional, Chang, Tiffany Y, additional, Gelston, Laura C, additional, Wang, Yong-Dong, additional, Mazor, Tali, additional, Esquivel, Emilio, additional, Yu, Ariel, additional, Seepo, Sara, additional, Olsen, Scott R, additional, Rosenberg, Mara, additional, Archambeault, Sophie L, additional, Abusin, Ghada, additional, Beckman, Kyle, additional, Brown, Patrick A, additional, Briones, Michael, additional, Carcamo, Benjamin, additional, Cooper, Todd, additional, Dahl, Gary V, additional, Emanuel, Peter D, additional, Fluchel, Mark N, additional, Goyal, Rakesh K, additional, Hayashi, Robert J, additional, Hitzler, Johann, additional, Hugge, Christopher, additional, Liu, Y Lucy, additional, Messinger, Yoav H, additional, Mahoney, Donald H, additional, Monteleone, Philip, additional, Nemecek, Eneida R, additional, Roehrs, Philip A, additional, Schore, Reuven J, additional, Stine, Kimo C, additional, Takemoto, Clifford M, additional, Toretsky, Jeffrey A, additional, Costello, Joseph F, additional, Olshen, Adam B, additional, Stewart, Chip, additional, Li, Yongjin, additional, Ma, Jing, additional, Gerbing, Robert B, additional, Alonzo, Todd A, additional, Getz, Gad, additional, Gruber, Tanja A, additional, Golub, Todd R, additional, Stegmaier, Kimberly, additional, and Loh, Mignon L, additional

Published
2015
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3. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway

Author

Shain, A Hunter, primary, Garrido, Maria, additional, Botton, Thomas, additional, Talevich, Eric, additional, Yeh, Iwei, additional, Sanborn, J Zachary, additional, Chung, Jongsuk, additional, Wang, Nicholas J, additional, Kakavand, Hojabr, additional, Mann, Graham J, additional, Thompson, John F, additional, Wiesner, Thomas, additional, Roy, Ritu, additional, Olshen, Adam B, additional, Gagnon, Alexander, additional, Gray, Joe W, additional, Huh, Nam, additional, Hur, Joe S, additional, Busam, Klaus J, additional, Scolyer, Richard A, additional, Cho, Raymond J, additional, Murali, Rajmohan, additional, and Bastian, Boris C, additional

Published
2015
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4. The genomic landscape of juvenile myelomonocytic leukemia.

Author

Toretsky, Jeffrey A, Olshen, Adam B, Getz, Gad, Gruber, Tanja A, Golub, Todd R, Stegmaier, Kimberly, Loh, Mignon L, Stieglitz, Elliot, Chang, Tiffany Y, Gelston, Laura C, Esquivel, Emilio, Yu, Ariel, Archambeault, Sophie L, Beckman, Kyle, Cooper, Todd, Dahl, Gary V, Emanuel, Peter D, Liu, Y Lucy, Fluchel, Mark N, and Goyal, Rakesh K

Subjects
*MONOCYTIC leukemia, *CHILDHOOD cancer, *STEM cell transplantation, *GENETIC mutation, *EPSTEIN-Barr virus, *DIAGNOSIS
Abstract

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies. In addition, few molecular pathways aside from the RAS-MAPK pathway have been identified that could serve as the basis for such novel therapeutic strategies. We therefore sought to genomically characterize serial samples from patients at diagnosis through relapse and transformation to acute myeloid leukemia to expand knowledge of the mutational spectrum in JMML. We identified recurrent mutations in genes involved in signal transduction, splicing, Polycomb repressive complex 2 (PRC2) and transcription. Notably, the number of somatic alterations present at diagnosis appears to be the major determinant of outcome. [ABSTRACT FROM AUTHOR]

Published
2015
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5. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.

Author

Garrido, Maria, Botton, Thomas, Talevich, Eric, Yeh, Iwei, Wang, Nicholas J, Kakavand, Hojabr, Mann, Graham J, Thompson, John F, Olshen, Adam B, Gagnon, Alexander, Gray, Joe W, Scolyer, Richard A, Murali, Rajmohan, Bastian, Boris C, Sanborn, J Zachary, Chung, Jongsuk, Huh, Nam, Wiesner, Thomas, Shain, A Hunter, and Roy, Ritu

Subjects
DESMOPLASTIC small round cell tumor, MELANOMA, MITOGEN-activated protein kinase phosphatases, GENETIC mutation, PHYSIOLOGICAL effects of ultraviolet radiation, COHORT analysis
Abstract

Desmoplastic melanoma is an uncommon variant of melanoma with sarcomatous histology, distinct clinical behavior and unknown pathogenesis. We performed low-coverage genome and high-coverage exome sequencing of 20 desmoplastic melanomas, followed by targeted sequencing of 293 genes in a validation cohort of 42 cases. A high mutation burden (median of 62 mutations/Mb) ranked desmoplastic melanoma among the most highly mutated cancers. Mutation patterns strongly implicate ultraviolet radiation as the dominant mutagen, indicating a superficially located cell of origin. Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-κB inhibitor ɛ (IκBɛ), in 14.5% of samples. Common oncogenic mutations in melanomas, in particular in BRAF (encoding p.Val600Glu) and NRAS (encoding p.Gln61Lys or p.Gln61Arg), were absent. Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2015
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6. Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

Author

Stieglitz, Elliot, Taylor-Weiner, Amaro N, Chang, Tiffany Y, Gelston, Laura C, Wang, Yong-Dong, Mazor, Tali, Esquivel, Emilio, Yu, Ariel, Seepo, Sara, Olsen, Scott R, Rosenberg, Mara, Archambeault, Sophie L, Abusin, Ghada, Beckman, Kyle, Brown, Patrick A, Briones, Michael, Carcamo, Benjamin, Cooper, Todd, Dahl, Gary V, Emanuel, Peter D, Fluchel, Mark N, Goyal, Rakesh K, Hayashi, Robert J, Hitzler, Johann, Hugge, Christopher, Liu, Y Lucy, Messinger, Yoav H, Mahoney, Donald H, Monteleone, Philip, Nemecek, Eneida R, Roehrs, Philip A, Schore, Reuven J, Stine, Kimo C, Takemoto, Clifford M, Toretsky, Jeffrey A, Costello, Joseph F, Olshen, Adam B, Stewart, Chip, Li, Yongjin, Ma, Jing, Gerbing, Robert B, Alonzo, Todd A, Getz, Gad, Gruber, Tanja A, Golub, Todd R, Stegmaier, Kimberly, and Loh, Mignon L

Published
2016
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