10 results on '"Eyjolfsson, Gudmundur I."'
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2. Identification of sequence variants influencing immunoglobulin levels
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Jonsson, Stefan, primary, Sveinbjornsson, Gardar, additional, de Lapuente Portilla, Aitzkoa Lopez, additional, Swaminathan, Bhairavi, additional, Plomp, Rosina, additional, Dekkers, Gillian, additional, Ajore, Ram, additional, Ali, Mina, additional, Bentlage, Arthur E H, additional, Elmér, Evelina, additional, Eyjolfsson, Gudmundur I, additional, Gudjonsson, Sigurjon A, additional, Gullberg, Urban, additional, Gylfason, Arnaldur, additional, Halldorsson, Bjarni V, additional, Hansson, Markus, additional, Holm, Hilma, additional, Johansson, Åsa, additional, Johnsson, Ellinor, additional, Jonasdottir, Aslaug, additional, Ludviksson, Bjorn R, additional, Oddsson, Asmundur, additional, Olafsson, Isleifur, additional, Olafsson, Sigurgeir, additional, Sigurdardottir, Olof, additional, Sigurdsson, Asgeir, additional, Stefansdottir, Lilja, additional, Masson, Gisli, additional, Sulem, Patrick, additional, Wuhrer, Manfred, additional, Wihlborg, Anna-Karin, additional, Thorleifsson, Gudmar, additional, Gudbjartsson, Daniel F, additional, Thorsteinsdottir, Unnur, additional, Vidarsson, Gestur, additional, Jonsdottir, Ingileif, additional, Nilsson, Björn, additional, and Stefansson, Kari, additional
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- 2017
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3. Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease
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Helgadottir, Anna, primary, Gretarsdottir, Solveig, additional, Thorleifsson, Gudmar, additional, Hjartarson, Eirikur, additional, Sigurdsson, Asgeir, additional, Magnusdottir, Audur, additional, Jonasdottir, Aslaug, additional, Kristjansson, Helgi, additional, Sulem, Patrick, additional, Oddsson, Asmundur, additional, Sveinbjornsson, Gardar, additional, Steinthorsdottir, Valgerdur, additional, Rafnar, Thorunn, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Olafsson, Isleifur, additional, Eyjolfsson, Gudmundur I, additional, Sigurdardottir, Olof, additional, Daneshpour, Maryam S, additional, Khalili, Davood, additional, Azizi, Fereidoun, additional, Swinkels, Dorine W, additional, Kiemeney, Lambertus, additional, Quyyumi, Arshed A, additional, Levey, Allan I, additional, Patel, Riyaz S, additional, Hayek, Salim S, additional, Gudmundsdottir, Ingibjorg J, additional, Thorgeirsson, Gudmundur, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F, additional, Holm, Hilma, additional, and Stefansson, Kari, additional
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- 2016
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4. A loss-of-function variant in ALOX15protects against nasal polyps and chronic rhinosinusitis
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Kristjansson, Ragnar P., Benonisdottir, Stefania, Davidsson, Olafur B., Oddsson, Asmundur, Tragante, Vinicius, Sigurdsson, Jon K., Stefansdottir, Lilja, Jonsson, Stefan, Jensson, Brynjar O., Arthur, Joseph G., Arnadottir, Gudny A., Sulem, Gerald, Halldorsson, Bjarni V., Gunnarsson, Bjarni, Halldorsson, Gisli H., Stefansson, Olafur A., Oskarsson, Gudjon R., Deaton, Aimee M., Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Onundarson, Pall T., Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn R., Ludviksdottir, Dora, Olafsdottir, Thorunn A., Rafnar, Thorunn, Masson, Gisli, Zink, Florian, Bjornsdottir, Gyda, Magnusson, Olafur Th., Bjornsdottir, Unnur S., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
- Abstract
Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P=8.0 × 10−27, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P=1.1 × 10−8, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. Our findings identify 15-LO as a potential target for therapeutic intervention in NP and CRS.
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- 2019
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5. Large-scale whole-genome sequencing of the Icelandic population
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Gudbjartsson, Daniel F, primary, Helgason, Hannes, additional, Gudjonsson, Sigurjon A, additional, Zink, Florian, additional, Oddson, Asmundur, additional, Gylfason, Arnaldur, additional, Besenbacher, Soren, additional, Magnusson, Gisli, additional, Halldorsson, Bjarni V, additional, Hjartarson, Eirikur, additional, Sigurdsson, Gunnar Th, additional, Stacey, Simon N, additional, Frigge, Michael L, additional, Holm, Hilma, additional, Saemundsdottir, Jona, additional, Helgadottir, Hafdis Th, additional, Johannsdottir, Hrefna, additional, Sigfusson, Gunnlaugur, additional, Thorgeirsson, Gudmundur, additional, Sverrisson, Jon Th, additional, Gretarsdottir, Solveig, additional, Walters, G Bragi, additional, Rafnar, Thorunn, additional, Thjodleifsson, Bjarni, additional, Bjornsson, Einar S, additional, Olafsson, Sigurdur, additional, Thorarinsdottir, Hildur, additional, Steingrimsdottir, Thora, additional, Gudmundsdottir, Thora S, additional, Theodors, Asgeir, additional, Jonasson, Jon G, additional, Sigurdsson, Asgeir, additional, Bjornsdottir, Gyda, additional, Jonsson, Jon J, additional, Thorarensen, Olafur, additional, Ludvigsson, Petur, additional, Gudbjartsson, Hakon, additional, Eyjolfsson, Gudmundur I, additional, Sigurdardottir, Olof, additional, Olafsson, Isleifur, additional, Arnar, David O, additional, Magnusson, Olafur Th, additional, Kong, Augustine, additional, Masson, Gisli, additional, Thorsteinsdottir, Unnur, additional, Helgason, Agnar, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
- Published
- 2015
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6. Discovery of common variants associated with low TSH levels and thyroid cancer risk
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Jonasson, Jon G, additional, Masson, Gisli, additional, He, Huiling, additional, Jonasdottir, Aslaug, additional, Sigurdsson, Asgeir, additional, Stacey, Simon N, additional, Johannsdottir, Hrefna, additional, Th Helgadottir, Hafdis, additional, Li, Wei, additional, Nagy, Rebecca, additional, Ringel, Matthew D, additional, Kloos, Richard T, additional, de Visser, Marieke C H, additional, Plantinga, Theo S, additional, den Heijer, Martin, additional, Aguillo, Esperanza, additional, Panadero, Angeles, additional, Prats, Enrique, additional, Garcia-Castaño, Almudena, additional, De Juan, Ana, additional, Rivera, Fernando, additional, Walters, G Bragi, additional, Bjarnason, Hjordis, additional, Tryggvadottir, Laufey, additional, Eyjolfsson, Gudmundur I, additional, Bjornsdottir, Unnur S, additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Kristjansson, Kristleifur, additional, Kristvinsson, Hoskuldur, additional, T Magnusson, Olafur, additional, Thorleifsson, Gudmar, additional, Gulcher, Jeffrey R, additional, Kong, Augustine, additional, Kiemeney, Lambertus ALM, additional, Jonsson, Thorvaldur, additional, Hjartarson, Hannes, additional, Mayordomo, Jose I, additional, Netea-Maier, Romana T, additional, de la Chapelle, Albert, additional, Hrafnkelsson, Jon, additional, Thorsteinsdottir, Unnur, additional, Rafnar, Thorunn, additional, and Stefansson, Kari, additional
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- 2012
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7. Identification of low-frequency variants associated with gout and serum uric acid levels
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Sulem, Patrick, primary, Gudbjartsson, Daniel F, additional, Walters, G Bragi, additional, Helgadottir, Hafdis T, additional, Helgason, Agnar, additional, Gudjonsson, Sigurjon A, additional, Zanon, Carlo, additional, Besenbacher, Soren, additional, Bjornsdottir, Gyda, additional, Magnusson, Olafur T, additional, Magnusson, Gisli, additional, Hjartarson, Eirikur, additional, Saemundsdottir, Jona, additional, Gylfason, Arnaldur, additional, Jonasdottir, Adalbjorg, additional, Holm, Hilma, additional, Karason, Ari, additional, Rafnar, Thorunn, additional, Stefansson, Hreinn, additional, Andreassen, Ole A, additional, Pedersen, Jesper H, additional, Pack, Allan I, additional, de Visser, Marieke C H, additional, Kiemeney, Lambertus A, additional, Geirsson, Arni J, additional, Eyjolfsson, Gudmundur I, additional, Olafsson, Isleifur, additional, Kong, Augustine, additional, Masson, Gisli, additional, Jonsson, Helgi, additional, Thorsteinsdottir, Unnur, additional, Jonsdottir, Ingileif, additional, and Stefansson, Kari, additional
- Published
- 2011
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8. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
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Gudbjartsson, Daniel F, primary, Bjornsdottir, Unnur S, additional, Halapi, Eva, additional, Helgadottir, Anna, additional, Sulem, Patrick, additional, Jonsdottir, Gudrun M, additional, Thorleifsson, Gudmar, additional, Helgadottir, Hafdis, additional, Steinthorsdottir, Valgerdur, additional, Stefansson, Hreinn, additional, Williams, Carolyn, additional, Hui, Jennie, additional, Beilby, John, additional, Warrington, Nicole M, additional, James, Alan, additional, Palmer, Lyle J, additional, Koppelman, Gerard H, additional, Heinzmann, Andrea, additional, Krueger, Marcus, additional, Boezen, H Marike, additional, Wheatley, Amanda, additional, Altmuller, Janine, additional, Shin, Hyoung Doo, additional, Uh, Soo-Taek, additional, Cheong, Hyun Sub, additional, Jonsdottir, Brynja, additional, Gislason, David, additional, Park, Choon-Sik, additional, Rasmussen, Linda M, additional, Porsbjerg, Celeste, additional, Hansen, Jakob W, additional, Backer, Vibeke, additional, Werge, Thomas, additional, Janson, Christer, additional, Jönsson, Ulla-Britt, additional, Ng, Maggie C Y, additional, Chan, Juliana, additional, So, Wing Yee, additional, Ma, Ronald, additional, Shah, Svati H, additional, Granger, Christopher B, additional, Quyyumi, Arshed A, additional, Levey, Allan I, additional, Vaccarino, Viola, additional, Reilly, Muredach P, additional, Rader, Daniel J, additional, Williams, Michael J A, additional, van Rij, Andre M, additional, Jones, Gregory T, additional, Trabetti, Elisabetta, additional, Malerba, Giovanni, additional, Pignatti, Pier Franco, additional, Boner, Attilio, additional, Pescollderungg, Lydia, additional, Girelli, Domenico, additional, Olivieri, Oliviero, additional, Martinelli, Nicola, additional, Ludviksson, Bjorn R, additional, Ludviksdottir, Dora, additional, Eyjolfsson, Gudmundur I, additional, Arnar, David, additional, Thorgeirsson, Gudmundur, additional, Deichmann, Klaus, additional, Thompson, Philip J, additional, Wjst, Matthias, additional, Hall, Ian P, additional, Postma, Dirkje S, additional, Gislason, Thorarinn, additional, Gulcher, Jeffrey, additional, Kong, Augustine, additional, Jonsdottir, Ingileif, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2009
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9. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Jonasson, Jon G, additional, Sigurdsson, Asgeir, additional, Bergthorsson, Jon T, additional, He, Huiling, additional, Blondal, Thorarinn, additional, Geller, Frank, additional, Jakobsdottir, Margret, additional, Magnusdottir, Droplaug N, additional, Matthiasdottir, Sigurborg, additional, Stacey, Simon N, additional, Skarphedinsson, Oskar B, additional, Helgadottir, Hafdis, additional, Li, Wei, additional, Nagy, Rebecca, additional, Aguillo, Esperanza, additional, Faure, Eduardo, additional, Prats, Enrique, additional, Saez, Berta, additional, Martinez, Mariano, additional, Eyjolfsson, Gudmundur I, additional, Bjornsdottir, Unnur S, additional, Holm, Hilma, additional, Kristjansson, Kristleifur, additional, Frigge, Michael L, additional, Kristvinsson, Hoskuldur, additional, Gulcher, Jeffrey R, additional, Jonsson, Thorvaldur, additional, Rafnar, Thorunn, additional, Hjartarsson, Hannes, additional, Mayordomo, Jose I, additional, de la Chapelle, Albert, additional, Hrafnkelsson, Jon, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
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- 2009
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10. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
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Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, and Kooner JS
- Subjects
- Delta-5 Fatty Acid Desaturase, Enzymes genetics, Humans, Polymorphism, Single Nucleotide, Enzymes blood, Genome-Wide Association Study, Liver enzymology
- Abstract
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
- Published
- 2011
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- View/download PDF
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