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Start Over Author "Dai, Wanjin" Journal nature genetics
2 results on '"Dai, Wanjin"'

1. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Author

Wu, Chen, primary, Miao, Xiaoping, additional, Huang, Liming, additional, Che, Xu, additional, Jiang, Guoliang, additional, Yu, Dianke, additional, Yang, Xianghong, additional, Cao, Guangwen, additional, Hu, Zhibin, additional, Zhou, Yongjian, additional, Zuo, Chaohui, additional, Wang, Chunyou, additional, Zhang, Xianghong, additional, Zhou, Yifeng, additional, Yu, Xianjun, additional, Dai, Wanjin, additional, Li, Zhaoshen, additional, Shen, Hongbing, additional, Liu, Luming, additional, Chen, Yanling, additional, Zhang, Sheng, additional, Wang, Xiaoqi, additional, Zhai, Kan, additional, Chang, Jiang, additional, Liu, Yu, additional, Sun, Menghong, additional, Cao, Wei, additional, Gao, Jun, additional, Ma, Ying, additional, Zheng, Xiongwei, additional, Cheung, Siu Tim, additional, Jia, Yongfeng, additional, Xu, Jian, additional, Tan, Wen, additional, Zhao, Ping, additional, Wu, Tangchun, additional, Wang, Chengfeng, additional, and Lin, Dongxin, additional

Published
2011
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2. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.

Author

Wu, Chen, Miao, Xiaoping, Huang, Liming, Che, Xu, Jiang, Guoliang, Yu, Dianke, Yang, Xianghong, Cao, Guangwen, Hu, Zhibin, Zhou, Yongjian, Zuo, Chaohui, Wang, Chunyou, Zhang, Xianghong, Zhou, Yifeng, Yu, Xianjun, Dai, Wanjin, Li, Zhaoshen, Shen, Hongbing, Liu, Luming, and Chen, Yanling

Subjects
CANCER patients, PANCREATIC cancer, CHINESE people, DISEASE susceptibility, POLYCYSTIC kidney disease, CHROMOSOMES, DISEASES
Abstract

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10?13 to P = 4.18 × 10?10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. [ABSTRACT FROM AUTHOR]

Published
2012
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