1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
- Author
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Okada, Yukinori, Terao, Chikashi, Ikari, Katsunori, Kochi, Yuta, Ohmura, Koichiro, Suzuki, Akari, Kawaguchi, Takahisa, Stahl, Eli A, Kurreeman, Fina A S, Nishida, Nao, Ohmiya, Hiroko, Myouzen, Keiko, Takahashi, Meiko, Sawada, Tetsuji, Nishioka, Yuichi, Yukioka, Masao, Matsubara, Tsukasa, Wakitani, Shigeyuki, Teshima, Ryota, and Tohma, Shigeto
- Subjects
GENETICS of rheumatoid arthritis ,JAPANESE people ,SYSTEMIC lupus erythematosus ,GRAVES' disease ,DISEASE susceptibility ,RHEUMATOID arthritis risk factors ,META-analysis ,COMPARATIVE studies ,GENETICS ,DISEASES - Abstract
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10
?8 , including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves' disease (P = 3.5 × 10?4 and 2.9 × 10?4 , respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations. [ABSTRACT FROM AUTHOR]- Published
- 2012
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