Search

Your search keyword '"Yun, Jing"' showing total 6 results
Start Over Author "Yun, Jing" Journal nature communications
6 results on '"Yun, Jing"'

1. Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma

Author

Liu, Yang, Ye, Shuang-Yan, He, Shuai, Chi, Dong-Mei, Wang, Xiu-Zhi, Wen, Yue-Feng, Ma, Dong, Nie, Run-Cong, Xiang, Pu, Zhou, You, Ruan, Zhao-Hui, Peng, Rou-Jun, Luo, Chun-Ling, Wei, Pan-Pan, Lin, Guo-Wang, Zheng, Jian, Cui, Qian, Cai, Mu-Yan, Yun, Jing-Ping, Dong, Junchao, Mai, Hai-Qiang, Xia, Xiaojun, and Bei, Jin-Xin

Published
2024
Full Text
View/download PDF

6. N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.

Author

Chen, Ri-Xin, Chen, Xin, Xia, Liang-Ping, Zhang, Jia-Xing, Pan, Zhi-Zhong, Ma, Xiao-Dan, Han, Kai, Chen, Jie-Wei, Judde, Jean-Gabrie, Deas, Olivier, Wang, Feng, Ma, Ning-Fang, Guan, Xinyuan, Yun, Jing-Ping, Wang, Feng-Wei, Xu, Rui-Hua, and Dan Xie

Subjects
LIVER metastasis, CIRCULAR RNA, CANCER invasiveness, PATIENTS, CANCER cells
Abstract

Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N6-methyladenosine (m6A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metastasis (LM) and predicts poorer patient survival. The upregulated expression of circNSUN2 promotes LM in PDX metastasis models in vivo and accelerates cancer cells invasion in vitro. Importantly, N6-methyladenosine modification of circNSUN2 increases export to the cytoplasm. By forming a circNSUN2/IGF2BP2/HMGA2 RNA-protein ternary complex in the cytoplasm, circNSUN2 enhances the stability of HMGA2 mRNA to promote CRC metastasis progression. Clinically, the upregulated expressions of circNSUN2 and HMGA2 are more prevalent in LM tissues than in primary CRC tissues. These findings elucidate that N6-methyladenosine modification of circNSUN2 modulates cytoplasmic export and stabilizes HMGA2 to promote CRC LM, and suggest that circNSUN2 could represent a critical prognostic marker and/or therapeutic target for the disease. Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results